Publications

Hwa Lab Studies Timeline

Publications List

Phenotypic and genotypic evaluation of bleeding diagnostic dilemmas: Two case studies.Gu SX, Butt A, Schulz VP, Rinder HM, Lee AI, Gallagher PG, Hwa J, Bona RD. Blood Cells Mol Dis. 2024 Sep 10; 2024 Sep 10. PMID: 39260211.
High-Dimensional Single-Cell Mass Cytometry Demonstrates Differential Platelet Functional Phenotypes in Infants With Congenital Heart Disease.Gu SX, Marcus BS, Gu VW, Varghese AP, Hwa J, Faustino EVS. Arterioscler Thromb Vasc Biol. 2024 Aug 22; 2024 Aug 22. PMID: 39171400.
Early thrombus formation is required for eccentric and heterogeneous neointimal hyperplasia under disturbed flow.Bai H, Li Z, Zhang W, Thaxton C, Ohashi Y, Gonzalez L, Kano M, Yatsula B, Hwa J, Dardik A. J Thromb Haemost. 2024 Aug 21; 2024 Aug 21. PMID: 39173878.
Methionine sulfoxide reductase B2 protects against cardiac complications in diabetes mellitus.Lee SH, Cho S, Lee JY, Kim JY, Kim S, Jeong M, Hong JY, Kim GY, Lee SW, Kim E, Kim J, Kim JW, Hwa J, Kim WH. Diabetol Metab Syndr. 2024 Jul 5; 2024 Jul 5. PMID: 38970135.
Novel strategies for targeting neutrophil against myocardial infarction.Jiang K, Hwa J, Xiang Y. Pharmacol Res. 2024 Jul; 2024 Jun 10. PMID: 38866263.
Platelet Mitochondrial Fusion and Function in Vascular Integrity.Tyagi T, Yarovinsky TO, Faustino EVS, Hwa J. Circ Res. 2024 Jan 19; 2024 Jan 18. PMID: 38236952.
Fishing for "complements" with vascular organoid models of microvascular disease.Gu SX, Yarovinsky TO, Hwa J. Cell Stem Cell. 2023 Oct 5. PMID: 37802032.
Lipid remodeling in megakaryocyte differentiation and platelet biogenesis.Jain K, Tyagi T, Hwa J. Nat Cardiovasc Res. 2023 Sep; 2023 Sep 4. PMID: 37736249.
Pyroptosis in cardiovascular diseases: Pumping gasdermin on the fire.Yarovinsky TO, Su M, Chen C, Xiang Y, Tang WH, Hwa J. Semin Immunol. 2023 Sep; 2023 Jul 19. PMID: 37478801.
Insights into platelet pharmacology from a cryo-EM structure of the ABCC4 transporter.Sharda AV, Gu SX, Hwa J. Nat Cardiovasc Res. 2023 Jul; 2023 Jun 19. PMID: 37655224.
SOD2 in platelets: with age comes responsibility.Jain K, Gu SX, Hwa J. J Thromb Haemost. 2023 May; 2023 Jan 27. PMID: 36716965.
Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS-CoV-2 infection (PASC) syndrome.Singh I, Leitner BP, Wang Y, Zhang H, Joseph P, Lutchmansingh DD, Gulati M, Possick JD, Damsky W, Hwa J, Heerdt PM, Chun HJ. Pulm Circ. 2023 Apr; 2023 Apr 1. PMID: 37091121.
Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells.Tyagi T, Jain K, Yarovinsky TO, Chiorazzi M, Du J, Castro C, Griffin J, Korde A, Martin KA, Takyar SS, Flavell RA, Patel AA, Hwa J. J Exp Med. 2023 Jan 2; 2022 Oct 28. PMID: 36305874.
The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques.Kabir I, Zhang X, Dave JM, Chakraborty R, Qu R, Chandran RR, Ntokou A, Gallardo-Vara E, Aryal B, Rotllan N, Garcia-Milian R, Hwa J, Kluger Y, Martin KA, Fernández-Hernando C, Greif DM. Nat Aging. 2023 Jan; 2023 Jan 9. PMID: 36743663.
Association of iron infusion reactions with ABO blood type.Butt A, Muradashvili T, Soliman S, Li F, Burns AJ, Brooks A, Browning S, Bar N, Borgman G, Goshua G, Hwa J, Martin K, Rinder H, Tormey C, Pine AB, Bona RD, Lee AI, Neparidze N. Eur J Haematol. 2022 Nov; 2022 Aug 9. PMID: 35871468.
Better together.Martin K, Hwa J. Science. 2022 Oct 28; 2022 Oct 27. PMID: 36302027.
Bone marrow-derived naïve B lymphocytes improve heart function after myocardial infarction: a novel cardioprotective mechanism for empagliflozin.Xu Y, Jiang K, Chen F, Qian J, Wang D, Wu Y, Zhou C, Yu Y, Chen K, Hwa J, Yang B, Wang H, Xiang Y. Basic Res Cardiol. 2022 Sep 28; 2022 Sep 28. PMID: 36171393.
Unfolded Protein Response Differentially Modulates the Platelet Phenotype.Jain K, Tyagi T, Du J, Hu X, Patell K, Martin KA, Hwa J. Circ Res. 2022 Aug 5; 2022 Jul 18. PMID: 35862006.
Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity.Chakraborty R, Ostriker AC, Xie Y, Dave JM, Gamez-Mendez A, Chatterjee P, Abu Y, Valentine J, Lezon-Geyda K, Greif DM, Schulz VP, Gallagher PG, Sessa WC, Hwa J, Martin KA. Circulation. 2022 Jun 7; 2022 May 3. PMID: 35502657.
Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis.Jiang K, Xu Y, Wang D, Chen F, Tu Z, Qian J, Xu S, Xu Y, Hwa J, Li J, Shang H, Xiang Y. Protein Cell. 2022 May; 2021 Jan 8. PMID: 33417139.
Muscle LIM Protein Force-Sensing Mediates Sarcomeric Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy.Riaz M, Park J, Sewanan LR, Ren Y, Schwan J, Das SK, Pomianowski PT, Huang Y, Ellis MW, Luo J, Liu J, Song L, Chen IP, Qiu C, Yazawa M, Tellides G, Hwa J, Young LH, Yang L, Marboe CC, Jacoby DL, Campbell SG, Qyang Y. Circulation. 2022 Apr 19; 2022 Apr 6. PMID: 35384713.
Sugar, Fat, and YAP: A Recipe for Vascular Stiffness.Mani A, Hwa J, Martin KA. Circ Res. 2022 Mar 18; 2022 Mar 17. PMID: 35298300.
A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences.Tyagi T, Jain K, Gu SX, Qiu M, Gu VW, Melchinger H, Rinder H, Martin KA, Gardiner EE, Lee AI, Ho Tang W, Hwa J. Nat Cardiovasc Res. 2022 Mar; 2022 Mar 3. PMID: 37502132.
Gasdermin D inhibition confers antineutrophil-mediated cardioprotection in acute myocardial infarction.Jiang K, Tu Z, Chen K, Xu Y, Chen F, Xu S, Shi T, Qian J, Shen L, Hwa J, Wang D, Xiang Y. J Clin Invest. 2022 Jan 4. PMID: 34752417.
Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis.Su M, Chen C, Li S, Li M, Zeng Z, Zhang Y, Xia L, Li X, Zheng D, Lin Q, Fan X, Wen Y, Liu Y, Chen F, Luo W, Bu Y, Qin J, Guo M, Qiu M, Sun L, Liu R, Wang P, Hwa J, Tang WH. Nat Cardiovasc Res. 2022; 2022 Aug 4. PMID: 35967457.
Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy.McConnell MJ, Kawaguchi N, Kondo R, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Lee AI, Pine AB, Chun HJ, Zhang X, Fernandez-Hernando C, Qing H, Wang A, Price C, Sun Z, Utsumi T, Hwa J, Strazzabosco M, Iwakiri Y. J Hepatol. 2021 Sep; 2021 May 13. PMID: 33991637.
TET2 Protects Against Vascular Smooth Muscle Cell Apoptosis and Intimal Thickening in Transplant Vasculopathy.Ostriker AC, Xie Y, Chakraborty R, Sizer AJ, Bai Y, Ding M, Song WL, Huttner A, Hwa J, Martin KA. Circulation. 2021 Aug 10; 2021 Jun 11. PMID: 34111946.
Low-dose Aspirin prevents hypertension and cardiac fibrosis when thromboxane A(2) is unrestrained.D'Agostino I, Tacconelli S, Bruno A, Contursi A, Mucci L, Hu X, Xie Y, Chakraborty R, Jain K, Sacco A, Zucchelli M, Landolfi R, Dovizio M, Falcone L, Ballerini P, Hwa J, Patrignani P. Pharmacol Res. 2021 Aug; 2021 Jun 26. PMID: 34182131.
Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension.Ntokou A, Dave JM, Kauffman AC, Sauler M, Ryu C, Hwa J, Herzog EL, Singh I, Saltzman WM, Greif DM. JCI Insight. 2021 Mar 22; 2021 Mar 22. PMID: 33591958.
A neutrophil activation signature predicts critical illness and mortality in COVID-19.Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun HJ. Blood Adv. 2021 Mar 9. PMID: 33635335.
Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation.Gu SX, Tyagi T, Jain K, Gu VW, Lee SH, Hwa JM, Kwan JM, Krause DS, Lee AI, Halene S, Martin KA, Chun HJ, Hwa J. Nat Rev Cardiol. 2021 Mar; 2020 Nov 19. PMID: 33214651.
Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation.Zeng Z, Xia L, Fan S, Zheng J, Qin J, Fan X, Liu Y, Tao J, Liu Y, Li K, Ling Z, Bu Y, Martin KA, Hwa J, Liu R, Tang WH. Circulation. 2021 Jan 26; 2020 Nov 19. PMID: 33207953.
Circulating markers of angiogenesis and endotheliopathy in COVID-19.Pine AB, Meizlish ML, Goshua G, Chang CH, Zhang H, Bishai J, Bahel P, Patel A, Gbyli R, Kwan JM, Won CH, Price C, Dela Cruz CS, Halene S, van Dijk D, Hwa J, Lee AI, Chun HJ. Pulm Circ. 2020 Oct-Dec; 2020 Nov 25. PMID: 33282193.
"CO"ping With a Sticky Situation.Jain K, Tyagi T, Hwa J. Arterioscler Thromb Vasc Biol. 2020 Oct; 2020 Sep 23. PMID: 32966131.
Reduced Platelet miR-223 Induction in Kawasaki Disease Leads to Severe Coronary Artery Pathology Through a miR-223/PDGFRβ Vascular Smooth Muscle Cell Axis.Zhang Y, Wang Y, Zhang L, Xia L, Zheng M, Zeng Z, Liu Y, Yarovinsky T, Ostriker AC, Fan X, Weng K, Su M, Huang P, Martin KA, Hwa J, Tang WH. Circ Res. 2020 Sep 11; 2020 Jun 29. PMID: 32597702.
A neutrophil activation signature predicts critical illness and mortality in COVID-19.Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun H. medRxiv. 2020 Sep 2; 2020 Sep 2. PMID: 32908988.
Parkin Coordinates Platelet Stress Response in Diabetes Mellitus: A Big Role in a Small Cell.Lee SH, Du J, Hwa J, Kim WH. Int J Mol Sci. 2020 Aug 15; 2020 Aug 15. PMID: 32824240.
Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Lancet Haematol. 2020 Aug; 2020 Jun 30. PMID: 32619411.
Circulating Markers of Angiogenesis and Endotheliopathy in COVID-19.Meizlish ML, Pine AB, Goshua G, Chang CH, Zhang H, Bishai J, Bahel P, Patel A, Gbyli R, Kwan J, Price C, Cruz CSD, Halene S, van Dijk D, Hwa J, Lee AI, Chun HJ. medRxiv. 2020 Jul 1; 2020 Jul 1. PMID: 32637968.
Role of Platelet Mitochondria: Life in a Nucleus-Free Zone.Melchinger H, Jain K, Tyagi T, Hwa J. Front Cardiovasc Med. 2019; 2019 Oct 29. PMID: 31737646.
Author's response to "platelet antioxidants: A conundrum in aging".Jain K, Tyagi T, Ionescu CN, Hwa J. EBioMedicine. 2019 Sep; 2019 Aug 27. PMID: 31471267.
CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation.Esteghamat F, Broughton JS, Smith E, Cardone R, Tyagi T, Guerra M, Szabó A, Ugwu N, Mani MV, Azari B, Kayingo G, Chung S, Fathzadeh M, Weiss E, Bender J, Mane S, Lifton RP, Adeniran A, Nathanson MH, Gorelick FS, Hwa J, Sahin-Tóth M, Belfort-DeAguiar R, Kibbey RG, Mani A. Nat Genet. 2019 Aug; 2019 Jul 29. PMID: 31358993.
Mitochondrial MsrB2 serves as a switch and transducer for mitophagy.Lee SH, Lee S, Du J, Jain K, Ding M, Kadado AJ, Atteya G, Jaji Z, Tyagi T, Kim WH, Herzog RI, Patel A, Ionescu CN, Martin KA, Hwa J. EMBO Mol Med. 2019 Aug; 2019 Jul 8. PMID: 31282614.
Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients.Jain K, Tyagi T, Patell K, Xie Y, Kadado AJ, Lee SH, Yarovinsky T, Du J, Hwang J, Martin KA, Testani J, Ionescu CN, Hwa J. EBioMedicine. 2019 Jun; 2019 May 24. PMID: 31130473.
Epithelial (E)-Cadherin is a Novel Mediator of Platelet Aggregation and Clot Stability.Scanlon VM, Teixeira AM, Tyagi T, Zou S, Zhang PX, Booth CJ, Kowalska MA, Bao J, Hwa J, Hayes V, Marks MS, Poncz M, Krause DS. Thromb Haemost. 2019 May; 2019 Mar 12. PMID: 30861547.
Platelet-derived miR-223 promotes a phenotypic switch in arterial injury repair.Zeng Z, Xia L, Fan X, Ostriker AC, Yarovinsky T, Su M, Zhang Y, Peng X, Xie Y, Pi L, Gu X, Chung SK, Martin KA, Liu R, Hwa J, Tang WH. J Clin Invest. 2019 Mar 1; 2019 Feb 18. PMID: 30645204.
Molecular Imaging of Factor XIII Activity for the Early Detection of Mouse Coronary Microvascular Disease.Zhuang ZW, Huang Y, Ju R, Maxfield MW, Ren Y, Wang X, Wang X, Stacy MR, Hwa J. Theranostics. 2019; 2019 Feb 20. PMID: 30867844.
Technical Feasibility of a Murine Model of Sleeve Gastrectomy with Ileal Transposition.Ying LD, Breuer GA, Hubbard MO, Nadzam GS, Hwa J, Martin KA. Obes Surg. 2019 Feb. PMID: 30353248.
LMO7 Is a Negative Feedback Regulator of Transforming Growth Factor β Signaling and Fibrosis.Xie Y, Ostriker AC, Jin Y, Hu H, Sizer AJ, Peng G, Morris AH, Ryu C, Herzog EL, Kyriakides T, Zhao H, Dardik A, Yu J, Hwa J, Martin KA. Circulation. 2019 Jan 29. PMID: 30586711.
Diabetes Exacerbates Myocardial Ischemia/Reperfusion Injury by Down-Regulation of MicroRNA and Up-Regulation of O-GlcNAcylation.Wang D, Hu X, Lee SH, Chen F, Jiang K, Tu Z, Liu Z, Du J, Wang L, Yin C, Liao Y, Shang H, Martin KA, Herzog RI, Young LH, Qian L, Hwa J, Xiang Y. JACC Basic Transl Sci. 2018 Jun; 2018 May 16. PMID: 30062222.
Opposing Actions of AKT (Protein Kinase B) Isoforms in Vascular Smooth Muscle Injury and Therapeutic Response.Jin Y, Xie Y, Ostriker AC, Zhang X, Liu R, Lee MY, Leslie KL, Tang W, Du J, Lee SH, Wang Y, Sessa WC, Hwa J, Yu J, Martin KA. Arterioscler Thromb Vasc Biol. 2017 Dec; 2017 Oct 12. PMID: 29025710.
SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume.Zou S, Teixeira AM, Kostadima M, Astle WJ, Radhakrishnan A, Simon LM, Truman L, Fang JS, Hwa J, Zhang PX, van der Harst P, Bray PF, Ouwehand WH, Frontini M, Krause DS. PLoS One. 2017; 2017 May 23. PMID: 28542600.
Leukaemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation.Zou S, Teixeira AM, Yin M, Xiang Y, Xavier-Ferrucio J, Zhang PX, Hwa J, Min W, Krause DS. Thromb Haemost. 2016 Aug 30; 2016 Jun 23. PMID: 27345948.
Inducing mitophagy in diabetic platelets protects against severe oxidative stress.Lee SH, Du J, Stitham J, Atteya G, Lee S, Xiang Y, Wang D, Jin Y, Leslie KL, Spollett G, Srivastava A, Mannam P, Ostriker A, Martin KA, Tang WH, Hwa J. EMBO Mol Med. 2016 Jul; 2016 Jul 1. PMID: 27221050.
Regulation of VWF expression, and secretion in health and disease.Xiang Y, Hwa J. Curr Opin Hematol. 2016 May. PMID: 26771163.
Familial dilated cardiomyopathy diagnosis is commonly overlooked at the time of transplant listing.Seidelmann SB, Laur O, Hwa J, Depasquale E, Bellumkonda L, Sugeng L, Pomianowski P, Testani J, Chen M, McKenna W, Jacoby D. J Heart Lung Transplant. 2016 Apr; 2015 Dec 11. PMID: 26852066.
The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation.Chae WJ, Ehrlich AK, Chan PY, Teixeira AM, Henegariu O, Hao L, Shin JH, Park JH, Tang WH, Kim ST, Maher SE, Goldsmith-Pestana K, Shan P, Hwa J, Lee PJ, Krause DS, Rothlin CV, McMahon-Pratt D, Bothwell AL. Immunity. 2016 Feb 16; 2016 Feb 9. PMID: 26872695.
SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression.Shao L, Zhou HJ, Zhang H, Qin L, Hwa J, Yun Z, Ji W, Min W. Nat Commun. 2015 Nov 24; 2015 Nov 24. PMID: 26596471.
Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor.Xiang Y, Cheng J, Wang D, Hu X, Xie Y, Stitham J, Atteya G, Du J, Tang WH, Lee SH, Leslie K, Spollett G, Liu Z, Herzog E, Herzog RI, Lu J, Martin KA, Hwa J. Blood. 2015 May 28; 2015 Mar 26. PMID: 25814526.
Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition.Xie Y, Jin Y, Merenick BL, Ding M, Fetalvero KM, Wagner RJ, Mai A, Gleim S, Tucker DF, Birnbaum MJ, Ballif BA, Luciano AK, Sessa WC, Rzucidlo EM, Powell RJ, Hou L, Zhao H, Hwa J, Yu J, Martin KA. Sci Signal. 2015 May 12; 2015 May 12. PMID: 25969542.
Individual variation of human S1P₁ coding sequence leads to heterogeneity in receptor function and drug interactions.Obinata H, Gutkind S, Stitham J, Okuno T, Yokomizo T, Hwa J, Hla T. J Lipid Res. 2014 Dec; 2014 Oct 7. PMID: 25293589.
Response to letter regarding article, "ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity".Liu R, Jin Y, Tang W, Qin L, Zhang X, Tellides G, Hwa J, Yu J, Martin KA. Circulation. 2014 Aug 19. PMID: 25135133.
A form of the metabolic syndrome associated with mutations in DYRK1B.Keramati AR, Fathzadeh M, Go GW, Singh R, Choi M, Faramarzi S, Mane S, Kasaei M, Sarajzadeh-Fard K, Hwa J, Kidd KK, Babaee Bigi MA, Malekzadeh R, Hosseinian A, Babaei M, Lifton RP, Mani A. N Engl J Med. 2014 May 15. PMID: 24827035.
Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets.Tang WH, Stitham J, Jin Y, Liu R, Lee SH, Du J, Atteya G, Gleim S, Spollett G, Martin K, Hwa J. Circulation. 2014 Apr 15; 2014 Jan 28. PMID: 24474649.
Inverse agonism of SQ 29,548 and Ramatroban on Thromboxane A2 receptor.Chakraborty R, Bhullar RP, Dakshinamurti S, Hwa J, Chelikani P. PLoS One. 2014; 2014 Jan 23. PMID: 24465800.
Editorial: pharmacogenetics and molecular medicine: "so close and yet so far".Moore JH, Hwa J. Curr Mol Med. 2014. PMID: 25109800.
Ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity.Liu R, Jin Y, Tang WH, Qin L, Zhang X, Tellides G, Hwa J, Yu J, Martin KA. Circulation. 2013 Oct 29; 2013 Sep 27. PMID: 24077167.
Patterns of change in nesiritide use in patients with heart failure: how hospitals react to new information.Partovian C, Li SX, Xu X, Lin H, Strait KM, Hwa J, Krumholz HM. JACC Heart Fail. 2013 Aug; 2013 Aug 5. PMID: 24621935.
Human thromboxane A2 receptor genetic variants: in silico, in vitro and "in platelet" analysis.Gleim S, Stitham J, Tang WH, Li H, Douville K, Chelikani P, Rade JJ, Martin KA, Hwa J. PLoS One. 2013; 2013 Jun 28. PMID: 23840660.
Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ. Circ Res. 2013 Jun 21; 2013 Apr 19. PMID: 23603510.
Biased suppression of TP homodimerization and signaling through disruption of a TM GxxxGxxxL helical interaction motif.Frey AJ, Ibrahim S, Gleim S, Hwa J, Smyth EM. J Lipid Res. 2013 Jun; 2013 Mar 14. PMID: 23493750.
Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome.Lemaire M, Frémeaux-Bacchi V, Schaefer F, Choi M, Tang WH, Le Quintrec M, Fakhouri F, Taque S, Nobili F, Martinez F, Ji W, Overton JD, Mane SM, Nürnberg G, Altmüller J, Thiele H, Morin D, Deschenes G, Baudouin V, Llanas B, Collard L, Majid MA, Simkova E, Nürnberg P, Rioux-Leclerc N, Moeckel GW, Gubler MC, Hwa J, Loirat C, Lifton RP. Nat Genet. 2013 May; 2013 Mar 31. PMID: 23542698.
New insights into structural determinants for prostanoid thromboxane A2 receptor- and prostacyclin receptor-G protein coupling.Chakraborty R, Pydi SP, Gleim S, Bhullar RP, Hwa J, Dakshinamurti S, Chelikani P. Mol Cell Biol. 2013 Jan; 2012 Oct 29. PMID: 23109431.
An eicosanoid-centric view of atherothrombotic risk factors.Gleim S, Stitham J, Tang WH, Martin KA, Hwa J. Cell Mol Life Sci. 2012 Oct; 2012 Apr 11. PMID: 22491820.
Exploration of the antiplatelet activity profile of betulinic acid on human platelets.Tzakos AG, Kontogianni VG, Tsoumani M, Kyriakou E, Hwa J, Rodrigues FA, Tselepis AD. J Agric Food Chem. 2012 Jul 18; 2012 Jul 3. PMID: 22720759.
Aldose reductase, oxidative stress, and diabetic mellitus.Tang WH, Martin KA, Hwa J. Front Pharmacol. 2012; 2012 May 9. PMID: 22582044.
Vascular smooth muscle cell-derived adiponectin: a paracrine regulator of contractile phenotype.Ding M, Carrão AC, Wagner RJ, Xie Y, Jin Y, Rzucidlo EM, Yu J, Li W, Tellides G, Hwa J, Aprahamian TR, Martin KA. J Mol Cell Cardiol. 2012 Feb; 2011 Sep 17. PMID: 21952104.
Site-directed mutations and the polymorphic variant Ala160Thr in the human thromboxane receptor uncover a structural role for transmembrane helix 4.Chakraborty R, Pydi SP, Gleim S, Dakshinamurti S, Hwa J, Chelikani P. PLoS One. 2012; 2012 Jan 17. PMID: 22272267.
Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane.Tang WH, Stitham J, Gleim S, Di Febbo C, Porreca E, Fava C, Tacconelli S, Capone M, Evangelista V, Levantesi G, Wen L, Martin K, Minuz P, Rade J, Patrignani P, Hwa J. J Clin Invest. 2011 Nov; 2011 Oct 17. PMID: 22005299.
Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin complex 1 and FoxO4.Ding M, Xie Y, Wagner RJ, Jin Y, Carrao AC, Liu LS, Guzman AK, Powell RJ, Hwa J, Rzucidlo EM, Martin KA. Arterioscler Thromb Vasc Biol. 2011 Jun; 2011 Mar 31. PMID: 21454807.
Prostacyclin: an inflammatory paradox.Stitham J, Midgett C, Martin KA, Hwa J. Front Pharmacol. 2011; 2011 May 13. PMID: 21687516.
Comprehensive biochemical analysis of rare prostacyclin receptor variants: study of association of signaling with coronary artery obstruction.Stitham J, Arehart E, Elderon L, Gleim SR, Douville K, Kasza Z, Fetalvero K, MacKenzie T, Robb J, Martin KA, Hwa J. J Biol Chem. 2011 Mar 4; 2010 Dec 28. PMID: 21189259.
NSAID use selectively increases the risk of non-fatal myocardial infarction: a systematic review of randomised trials and observational studies.García Rodríguez LA, González-Pérez A, Bueno H, Hwa J. PLoS One. 2011 Feb 8; 2011 Feb 8. PMID: 21347435.
Opsin is a phospholipid flippase.Menon I, Huber T, Sanyal S, Banerjee S, Barré P, Canis S, Warren JD, Hwa J, Sakmar TP, Menon AK. Curr Biol. 2011 Jan 25; 2011 Jan 13. PMID: 21236677.
Dominant negative actions of human prostacyclin receptor variant through dimerization: implications for cardiovascular disease.Ibrahim S, Tetruashvily M, Frey AJ, Wilson SJ, Stitham J, Hwa J, Smyth EM. Arterioscler Thromb Vasc Biol. 2010 Sep; 2010 Jun 3. PMID: 20522800.
Prostacyclin receptor/thromboxane receptor interactions and cellular responses in human atherothrombotic disease.Gleim S, Kasza Z, Martin K, Hwa J. Curr Atheroscler Rep. 2009 May. PMID: 19361355.
Novel signaling pathways promote a paracrine wave of prostacyclin-induced vascular smooth muscle differentiation.Kasza Z, Fetalvero KM, Ding M, Wagner RJ, Acs K, Guzman AK, Douville KL, Powell RJ, Hwa J, Martin KA. J Mol Cell Cardiol. 2009 May; 2009 Jan 23. PMID: 19302827.
Multifactor dimensionality reduction analysis identifies specific nucleotide patterns promoting genetic polymorphisms.Arehart E, Gleim S, White B, Hwa J, Moore JH. BioData Min. 2009 Mar 30; 2009 Mar 30. PMID: 19331672.
Conserved rhodopsin intradiscal structural motifs mediate stabilization: effects of zinc.Gleim S, Stojanovic A, Arehart E, Byington D, Hwa J. Biochemistry. 2009 Mar 3. PMID: 19206210.
The human prostacyclin receptor from structure function to disease.Martin KA, Gleim S, Elderon L, Fetalvero K, Hwa J. Prog Mol Biol Transl Sci. 2009; 2009 Oct 7. PMID: 20374736.
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.Ogden SK, Fei DL, Schilling NS, Ahmed YF, Hwa J, Robbins DJ. Nature. 2008 Dec 18. PMID: 18987629.
Prostacyclin primes pregnant human myometrium for an enhanced contractile response in parturition.Fetalvero KM, Zhang P, Shyu M, Young BT, Hwa J, Young RC, Martin KA. J Clin Invest. 2008 Dec; 2008 Nov 20. PMID: 19033666.
Shp shape: FAKs about hypertrophy.Martin KA, Hwa J. Circ Res. 2008 Oct 10. PMID: 18845815.
Differential association between human prostacyclin receptor polymorphisms and the development of venous thrombosis and intimal hyperplasia: a clinical biomarker study.Patrignani P, Di Febbo C, Tacconelli S, Douville K, Guglielmi MD, Horvath RJ, Ding M, Sierra K, Stitham J, Gleim S, Baccante G, Moretta V, Di Francesco L, Capone ML, Porreca E, Hwa J. Pharmacogenet Genomics. 2008 Jul. PMID: 18551041.
Adenylyl cyclase type 6 overexpression selectively enhances beta-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts.Liu X, Thangavel M, Sun SQ, Kaminsky J, Mahautmr P, Stitham J, Hwa J, Ostrom RS. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun; 2007 Oct 13. PMID: 17934720.
Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition.Arehart E, Stitham J, Asselbergs FW, Douville K, MacKenzie T, Fetalvero KM, Gleim S, Kasza Z, Rao Y, Martel L, Segel S, Robb J, Kaplan A, Simons M, Powell RJ, Moore JH, Rimm EB, Martin KA, Hwa J. Circ Res. 2008 Apr 25; 2008 Mar 6. PMID: 18323528.
Arginine (CGC) codon targeting in the human prostacyclin receptor gene (PTGIR) and G-protein coupled receptors (GPCR).Stitham J, Arehart EJ, Gleim S, Douville K, MacKenzie T, Hwa J. Gene. 2007 Jul 1; 2007 Apr 1. PMID: 17481829.
Cardioprotective prostacyclin signaling in vascular smooth muscle.Fetalvero KM, Martin KA, Hwa J. Prostaglandins Other Lipid Mediat. 2007 Jan; 2006 Jul 7. PMID: 17164138.
Human prostacyclin receptor structure and function from naturally-occurring and synthetic mutations.Stitham J, Arehart EJ, Gleim SR, Douville KL, Hwa J. Prostaglandins Other Lipid Mediat. 2007 Jan; 2006 Jul 3. PMID: 17164137.
Versatility and differential roles of cysteine residues in human prostacyclin receptor structure and function.Stitham J, Gleim SR, Douville K, Arehart E, Hwa J. J Biol Chem. 2006 Dec 1; 2006 Oct 2. PMID: 17015447.