2010
A network approach to assessing cognition in disorders of consciousness(e–Pub ahead of print)(CME)
Rodriguez Moreno D, Schiff N, Giacino J, Kalmar K, Hirsch J. A network approach to assessing cognition in disorders of consciousness(e–Pub ahead of print)(CME). Neurology 2010, 75: 1871-1878. PMID: 20980667, PMCID: PMC2995384, DOI: 10.1212/wnl.0b013e3181feb259.Peer-Reviewed Original ResearchMeSH KeywordsAdultAwarenessBrainCognitionConsciousness DisordersFemaleGlasgow Coma ScaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPattern Recognition, VisualPersistent Vegetative StatePoint-of-Care SystemsQuadriplegiaSensitivity and SpecificityVerbal BehaviorYoung AdultConceptsDisorders of consciousnessVegetative stateComa Recovery ScaleHigh-level cognitionObject-naming taskPicture-naming taskLanguage-related regionsElicit brain activationEMCS patientsVS patientsHealthy subjectsDiagnostic criteriaPatientsVolitional processesRecovery ScaleBrain activationLanguage networkFMRI studyMotor responseOvert behaviorConscious stateNeural systemsBehavioral assessmentCognitionPartial preservation
2009
11C-Dihydrotetrabenazine PET of the Pancreas in Subjects with Long-Standing Type 1 Diabetes and in Healthy Controls
Goland R, Freeby M, Parsey R, Saisho Y, Kumar D, Simpson N, Hirsch J, Prince M, Maffei A, Mann JJ, Butler PC, Van Heertum R, Leibel RL, Ichise M, Harris PE. 11C-Dihydrotetrabenazine PET of the Pancreas in Subjects with Long-Standing Type 1 Diabetes and in Healthy Controls. Journal Of Nuclear Medicine 2009, 50: 382-389. PMID: 19223416, PMCID: PMC3629294, DOI: 10.2967/jnumed.108.054866.Peer-Reviewed Original ResearchConceptsBeta-cell massType 1 diabetesInsulin secretionVMAT2 bindingRenal cortexLong-Standing Type 1 DiabetesType 2 vesicular monoamine transporterFunctional binding capacityBinding capacityVesicular monoamine transporterInsulin secretion measurementsHealthy controlsHigh nonspecific bindingHealthy subjectsPatientsPreclinical experimentsControl valuesHuman pancreasDiabetesPancreasSecretion measurementsMonoamine transportersReference tissueCortexVMAT2