2011
Differences in Regional Brain Activation Patterns Assessed by Functional Magnetic Resonance Imaging in Patients with Systemic Lupus Erythematosus Stratified by Disease Duration
Mackay M, Bussa MP, Aranow C, Uluğ AM, Volpe BT, Huerta PT, Argyelan M, Mandel A, Hirsch J, Diamond B, Eidelberg D. Differences in Regional Brain Activation Patterns Assessed by Functional Magnetic Resonance Imaging in Patients with Systemic Lupus Erythematosus Stratified by Disease Duration. Molecular Medicine 2011, 17: 1349-1356. PMID: 21953419, PMCID: PMC3321819, DOI: 10.2119/molmed.2011.00185.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusBlood-brain barrierFunctional magnetic resonance imagingTissue damageDisease durationBrain activation patternsLupus erythematosusST groupSystemic Lupus International Collaborating Clinics Damage IndexActivation patternsFearful face paradigmRegional brain activation patternsDuration of diseaseRegional brain abnormalitiesCentral nervous systemMagnetic resonance imagingFunctional magnetic resonanceCorticosteroid dosesDisease activityComorbid diseasesSLE patientsImmune cellsVascular diseaseBrain injuryBrain abnormalities
2007
Quantitative objective markers for upper and lower motor neuron dysfunction in ALS
Mitsumoto H, Ulu A, Pullman S, Gooch C, Chan S, Tang M, Mao X, Hays A, Floyd A, Battista V, Montes J, Hayes S, Dashnaw S, Kaufmann P, Gordon P, Hirsch J, Levin B, Rowland L, Shungu D. Quantitative objective markers for upper and lower motor neuron dysfunction in ALS. Neurology 2007, 68: 1402-1410. PMID: 17452585, DOI: 10.1212/01.wnl.0000260065.57832.87.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmyotrophic Lateral SclerosisAspartic AcidBiomarkersCreatineDiffusion Magnetic Resonance ImagingFemaleFollow-Up StudiesHumansMagnetic Resonance SpectroscopyMaleMiddle AgedMotor CortexMotor Neuron DiseaseMotor NeuronsMuscular Atrophy, SpinalNeural ConductionProspective StudiesTranscranial Magnetic StimulationConceptsMotor unit number estimationCentral motor conduction timeMotor conduction timeAcetyl-aspartate concentrationsUMN syndromeControl subjectsTibialis anteriorConduction timeObjective markersLower motor neuron dysfunctionLower motor neuron involvementALS Functional RatingMotor neuron involvementMotor neuron dysfunctionProton MR spectroscopic imagingTranscranial magnetic stimulationRatio of NAADiffusion tensor imagingLMN syndromesDisease activityNeuron involvementNeuron dysfunctionMR spectroscopic imagingFunctional ratingObjective biomarkers