Dr. Stephanie Halene Appointed Chief of Hematology at Yale Cancer Center and Smilow Cancer Hospital
Following an extensive national search, Stephanie Halene, MD, PhD, has been appointed Chief of Hematology at Yale Cancer Center, Smilow Cancer Hospital and the Yale School of Medicine Department of Internal Medicine.
With Barcoding, a Better Understanding of Life Forms
Because of the very complicated organization of tissues and cells, it’s still not entirely understood how tumors form, for instance, or how different organs emerge in early-stage embryos. To help answer these crucial questions, a team of researchers at Yale have developed a technology that gives a much clearer picture of the spatial relationships in biological systems. The process, which involves barcoding cells in tissue, was developed in the lab of Rong Fan, professor of biomedical engineering. The results were published Nov. 13 in Cell. The authors include Yale BME postdocs, graduate students, and undergraduate students in Fan lab and collaborators from Yale School of Medicine including Prof. Stephanie Halene, interim section chief of hematology.Source: Yale SEAS News
Humanized Mice Lead to Breakthroughs in Blood Cancers
Humanized mice created at Yale are opening new avenues of research into cancers caused by disorders in the production of blood, such as acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS). Until recently, such research was hindered because human blood stem cells are difficult to grow in cell cultures or to engraft in mice.
Breaking new ground: Yale team implants human innate immune cells in mice
Overcoming a major limitation to the study of the origins and progress of human disease, Yale researchers report that they have transplanted human innate immune cells into mouse models, which resulted in human immune responses. This groundbreaking study has reproduced human immune function at a level not seen previously, and could significantly improve the translation of knowledge gained from mouse studies into humans. The study is published online in Nature Biotechnology.
How megakaryocytes get so big — and the bad things that happen when they don’t
Yale researchers have discovered how megakaryocytes — giant blood cells that produce wound-healing platelets — manage to grow 10 to 15 times larger than other blood cells. The findings, to be published March 13 in the journal Developmental Cell, also hint at how a malfunction in this process may cause a form of leukemia.