2018
Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure
Nomura S, Satoh M, Fujita T, Higo T, Sumida T, Ko T, Yamaguchi T, Tobita T, Naito AT, Ito M, Fujita K, Harada M, Toko H, Kobayashi Y, Ito K, Takimoto E, Akazawa H, Morita H, Aburatani H, Komuro I. Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure. Nature Communications 2018, 9: 4435. PMID: 30375404, PMCID: PMC6207673, DOI: 10.1038/s41467-018-06639-7.Peer-Reviewed Original ResearchConceptsCardiac hypertrophyCardiomyocyte remodelingGene programHeart failurePressure overloadMorphological hypertrophyHeart functionHypertrophyP53 deletionEarly hypertrophyFunctional signaturesFunctional phenotypeLate hypertrophyP53 signalingTranscriptional signatureProgram activationMitochondrial inhibitionUnderlying mechanismCardiomyocyte identityCardiomyocytesMitochondrial activationRemodelingFailureTranscriptional programsActivation
2015
A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling
Nakayama A, Morita H, Nakao T, Yamaguchi T, Sumida T, Ikeda Y, Kumagai H, Motozawa Y, Takahashi T, Imaizumi A, Hashimoto T, Nagai R, Komuro I. A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling. PLOS ONE 2015, 10: e0137106. PMID: 26327560, PMCID: PMC4556625, DOI: 10.1371/journal.pone.0137106.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAnimalsAntioxidantsAtrial Natriuretic FactorConnective Tissue Growth FactorDietFibroblastsFibrosisFlavonoidsFoodHeartHydrogen PeroxideHypertrophyLuteolinMaleMyocardiumOxidative StressPhosphorylationRatsRats, Sprague-DawleySignal TransductionTransforming Growth Factor beta1Ventricular RemodelingConceptsCardiac remodelingAng IIOral pretreatmentII-Induced Cardiac RemodelingOxidative stressCultured rat cardiac fibroblastsRat cardiac fibroblastsPhosphorylation of JNKHyperoxidative stateAntifibrotic effectsCardiac fibrosisCardiac functionLuteolin pretreatmentTGFβ1 expressionCardiac fibroblastsPotent antioxidantHerbal extractsProtective actionCardiac tissueRemodelingExpression levelsGene expression levelsDietPretreatmentProtective properties