1991
Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis
Hafler D, Orav J, Gertz R, Stazzone L, Weiner H. Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis. Journal Of Neuroimmunology 1991, 32: 149-158. PMID: 1672870, DOI: 10.1016/0165-5728(91)90007-t.Peer-Reviewed Original ResearchConceptsT cell populationsDisability Status ScaleMixed lymphocyte reactionSpontaneous proliferationT cellsImmune measuresACTH infusionImmune functionChronic progressive multiple sclerosisProgressive multiple sclerosis patientsCD4/CD8 ratioCell populationsAllogeneic mixed lymphocyte reactionFunctional immune measuresPeripheral blood CD4Progressive multiple sclerosisPositive clinical responsePositive T cellsMultiple sclerosis patientsFunctional immune assaysLevels of proliferationBlood CD4CD8 ratioClinical improvementClinical response
1988
Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis.
Hafler DA, Duby AD, Lee SJ, Benjamin D, Seidman JG, Weiner HL. Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis. Journal Of Experimental Medicine 1988, 167: 1313-1322. PMID: 3258624, PMCID: PMC2188923, DOI: 10.1084/jem.167.4.1313.Peer-Reviewed Original ResearchConceptsT cell clonesT cell populationsOligoclonal T-cell populationsTCR gene rearrangement patternsCerebrospinal fluidGene rearrangement patternsCell clonesT cellsRearrangement patternsChronic progressive multiple sclerosis patientsProgressive multiple sclerosis patientsCell populationsChronic progressive MSHerpes zoster meningoencephalitisOligoclonal T lymphocytesOligoclonal T cellsT cell responsesMultiple sclerosis patientsCentral nervous systemT cell receptor beta chainTCR gene rearrangementsIndividual T cellsProgressive MSGamma chain geneImmune compartment
1987
T Cells in Multiple Sclerosis and Inflammatory Central Nervous System Diseases
Hafler D, Weiner H. T Cells in Multiple Sclerosis and Inflammatory Central Nervous System Diseases. Immunological Reviews 1987, 100: 307-332. PMID: 3326824, DOI: 10.1111/j.1600-065x.1987.tb00537.x.Peer-Reviewed Original ResearchConceptsT cellsInflammatory responseCNS tissueInflammatory central nervous system diseasesProgressive multiple sclerosis patientsCentral nervous system diseaseClass II MHC antigensMonoclonal antibodiesT-cell receptor gene rearrangementsCSF T cellsOngoing inflammatory responseTotal T cellsInflammatory CNS diseaseMultiple sclerosis patientsAntigen-presenting cellsAnti-measles antibodiesChronic disease processesAntigen-specific cellsNervous system diseasesReceptor gene rearrangementsMurine monoclonal antibodiesSelective accumulationAlpha beta chainsCNS damageSclerosis patients
1986
Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12.
Hafler D, Fallis R, Dawson D, Schlossman S, Reinherz E, Weiner H. Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12. Neurology 1986, 36: 777-84. PMID: 3486383, DOI: 10.1212/wnl.36.6.777.Peer-Reviewed Original ResearchConceptsHuman anti-mouse antibodiesAnti-mouse antibodiesDay 3Anti-T cell monoclonal antibodiesProgressive multiple sclerosis patientsPost-thymic T cellsMultiple sclerosis patientsMild allergic reactionsProgression of diseaseMonoclonal Antibodies ReactiveEffect of treatmentPhase one studyProgressive MSClinical effectsSclerosis patientsImmunologic responseBlood levelsImmunologic studiesPokeweed mitogenAllergic reactionsT cellsAntibody reactivePatientsDay 1Day 7