Publications

• Neuroinflammation in Alzheimer disease.Heneka MT, van der Flier WM, Jessen F, Hoozemanns J, Thal DR, Boche D, Brosseron F, Teunissen C, Zetterberg H, Jacobs AH, Edison P, Ramirez A, Cruchaga C, Lambert JC, Laza AR, Sanchez-Mut JV, Fischer A, Castro-Gomez S, Stein TD, Kleineidam L, Wagner M, Neher JJ, Cunningham C, Singhrao SK, Prinz M, Glass CK, Schlachetzki JCM, Butovsky O, Kleemann K, De Jaeger PL, Scheiblich H, Brown GC, Landreth G, Moutinho M, Grutzendler J, Gomez-Nicola D, McManus RM, Andreasson K, Ising C, Karabag D, Baker DJ, Liddelow SA, Verkhratsky A, Tansey M, Monsonego A, Aigner L, Dorothée G, Nave KA, Simons M, Constantin G, Rosenzweig N, Pascual A, Petzold GC, Kipnis J, Venegas C, Colonna M, Walter J, Tenner AJ, O'Banion MK, Steinert JR, Feinstein DL, Sastre M, Bhaskar K, Hong S, Schafer DP, Golde T, Ransohoff RM, Morgan D, Breitner J, Mancuso R, Riechers SP. Nat Rev Immunol. 2024 Dec 9; 2024 Dec 9. PMID: 39653749.
• mTORC1 Signaling in Brain Endothelial Progenitors Contributes to CCM Pathogenesis.Min W, Qin L, Zhang H, López-Giráldez F, Jiang N, Kim Y, Mohan VK, Su M, Murray KN, Grutzendler J, Zhou JH. Circ Res. 2024 Aug 2; 2024 Jul 3. PMID: 38957991.
• Single cell in vivo optogenetic stimulation by two-photon excitation fluorescence transfer.Tong L, Han S, Xue Y, Chen M, Chen F, Ke W, Shu Y, Ding N, Bewersdorf J, Zhou ZJ, Yuan P, Grutzendler J. iScience. 2023 Oct 20; 2023 Sep 9. PMID: 37752954.
• TREM2 and APOE do not modulate phagocytic clearance of dying cells in the live mammalian brain.Damisah EC, Rai A, Hill RA, Tong L, Grutzendler J. bioRxiv. 2023 Mar 23; 2023 Mar 23. PMID: 36993245.
• PLD3 affects axonal spheroids and network defects in Alzheimer's disease.Yuan P, Zhang M, Tong L, Morse TM, McDougal RA, Ding H, Chan D, Cai Y, Grutzendler J. Nature. 2022 Dec; 2022 Nov 30. PMID: 36450991.
• Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death.Aber ER, Griffey CJ, Davies T, Li AM, Yang YJ, Croce KR, Goldman JE, Grutzendler J, Canman JC, Yamamoto A. Cell Rep. 2022 Oct 18. PMID: 36261002.
• KCNJ8/ABCC9-containing K-ATP channel modulates brain vascular smooth muscle development and neurovascular coupling.Ando K, Tong L, Peng D, Vázquez-Liébanas E, Chiyoda H, He L, Liu J, Kawakami K, Mochizuki N, Fukuhara S, Grutzendler J, Betsholtz C. Dev Cell. 2022 Jun 6; 2022 May 18. PMID: 35588738.
• Intravital Imaging of Neocortical Heterotopia Reveals Aberrant Axonal Pathfinding and Myelination around Ectopic Neurons.Li AM, Hill RA, Grutzendler J. Cereb Cortex. 2021 Jul 29. PMID: 33877363.
• 3D super-resolution deep-tissue imaging in living mice.Velasco MGM, Zhang M, Antonello J, Yuan P, Allgeyer ES, May D, M'Saad O, Kidd P, Barentine AES, Greco V, Grutzendler J, Booth MJ, Bewersdorf J. Optica. 2021 Apr 20; 2021 Mar 25. PMID: 34239948.
• Unlocking Pericyte Function in the Adult Blood Brain Barrier One Cell at a Time.Nicoli S, Grutzendler J. Circ Res. 2021 Feb 19; 2021 Feb 18. PMID: 33600230.
• Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model.Zhou HJ, Qin L, Jiang Q, Murray KN, Zhang H, Li B, Lin Q, Graham M, Liu X, Grutzendler J, Min W. Nat Commun. 2021 Jan 25; 2021 Jan 25. PMID: 33495460.
• Imaging and optogenetic modulation of vascular mural cells in the live brain.Tong L, Hill RA, Damisah EC, Murray KN, Yuan P, Bordey A, Grutzendler J. Nat Protoc. 2021 Jan; 2020 Dec 9. PMID: 33299155.
• Emerging technologies to study glial cells.Hirbec H, Déglon N, Foo LC, Goshen I, Grutzendler J, Hangen E, Kreisel T, Linck N, Muffat J, Regio S, Rion S, Escartin C. Glia. 2020 Sep; 2020 Jan 20. PMID: 31958188.
• Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo.Damisah EC, Hill RA, Rai A, Chen F, Rothlin CV, Ghosh S, Grutzendler J. Sci Adv. 2020 Jun; 2020 Jun 26. PMID: 32637606.
• TREM2: Modulator of Lipid Metabolism in Microglia.Damisah EC, Rai A, Grutzendler J. Neuron. 2020 Mar 4. PMID: 32135085.
• Uncovering the biology of myelin with optical imaging of the live brain.Hill RA, Grutzendler J. Glia. 2019 Nov; 2019 Apr 29. PMID: 31033062.
• Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas.Grutzendler J, Nedergaard M. Trends Neurosci. 2019 Aug; 2019 Jun 26. PMID: 31255380.
• Publisher Correction: Flexible Learning-Free Segmentation and Reconstruction of Neural Volumes.Shahbazi A, Kinnison J, Vescovi R, Du M, Hill R, Joesch M, Takeno M, Zeng H, da Costa NM, Grutzendler J, Kasthuri N, Scheirer WJ. Sci Rep. 2018 Nov 29; 2018 Nov 29. PMID: 30498261.
• Flexible Learning-Free Segmentation and Reconstruction of Neural Volumes.Shahbazi A, Kinnison J, Vescovi R, Du M, Hill R, Joesch M, Takeno M, Zeng H, da Costa NM, Grutzendler J, Kasthuri N, Scheirer WJ. Sci Rep. 2018 Sep 24; 2018 Sep 24. PMID: 30250218.
• Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain.Hill RA, Li AM, Grutzendler J. Nat Neurosci. 2018 May; 2018 Mar 19. PMID: 29556031.
• Activation of pial and dural macrophages and dendritic cells by cortical spreading depression.Schain AJ, Melo-Carrillo A, Borsook D, Grutzendler J, Strassman AM, Burstein R. Ann Neurol. 2018 Mar; 2018 Mar 13. PMID: 29394508.
• Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.Condello C, Yuan P, Grutzendler J. Biol Psychiatry. 2018 Feb 15; 2017 Oct 14. PMID: 29169609.
• Oxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer's disease.Yang J, Zhang X, Yuan P, Yang J, Xu Y, Grutzendler J, Shao Y, Moore A, Ran C. Proc Natl Acad Sci U S A. 2017 Nov 21; 2017 Nov 6. PMID: 29109280.
• A fluoro-Nissl dye identifies pericytes as distinct vascular mural cells during in vivo brain imaging.Damisah EC, Hill RA, Tong L, Murray KN, Grutzendler J. Nat Neurosci. 2017 Jul; 2017 May 15. PMID: 28504673.
• Targeted two-photon chemical apoptotic ablation of defined cell types in vivo.Hill RA, Damisah EC, Chen F, Kwan AC, Grutzendler J. Nat Commun. 2017 Jun 16; 2017 Jun 16. PMID: 28621306.
• "Small Blood Vessels: Big Health Problems?": Scientific Recommendations of the National Institutes of Health Workshop.Bosetti F, Galis ZS, Bynoe MS, Charette M, Cipolla MJ, Del Zoppo GJ, Gould D, Hatsukami TS, Jones TL, Koenig JI, Lutty GA, Maric-Bilkan C, Stevens T, Tolunay HE, Koroshetz W. J Am Heart Assoc. 2016 Nov 4; 2016 Nov 4. PMID: 27815267.
• TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J. Neuron. 2016 Oct 5. PMID: 27710785.
• TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J. Neuron. 2016 May 18. PMID: 27196974.
• TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques.Wang Y, Ulland TK, Ulrich JD, Song W, Tzaferis JA, Hole JT, Yuan P, Mahan TE, Shi Y, Gilfillan S, Cella M, Grutzendler J, DeMattos RB, Cirrito JR, Holtzman DM, Colonna M. J Exp Med. 2016 May 2; 2016 Apr 18. PMID: 27091843.
• Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging.Han L, Kong DK, Zheng MQ, Murikinati S, Ma C, Yuan P, Li L, Tian D, Cai Q, Ye C, Holden D, Park JH, Gao X, Thomas JL, Grutzendler J, Carson RE, Huang Y, Piepmeier JM, Zhou J. ACS Nano. 2016 Apr 26; 2016 Mar 16. PMID: 26967254.
• Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium.Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV. Front Neurosci. 2016; 2016 Feb 22. PMID: 26941593.
• Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity.Yuan P, Grutzendler J. J Neurosci. 2016 Jan 13. PMID: 26758850.
• Absolute two-photon excitation spectra of red and far-red fluorescent probes.Velasco MG, Allgeyer ES, Yuan P, Grutzendler J, Bewersdorf J. Opt Lett. 2015 Nov 1. PMID: 26512482.
• Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques.Gowrishankar S, Yuan P, Wu Y, Schrag M, Paradise S, Grutzendler J, De Camilli P, Ferguson SM. Proc Natl Acad Sci U S A. 2015 Jul 14; 2015 Jun 29. PMID: 26124111.
• Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes.Hill RA, Tong L, Yuan P, Murikinati S, Gupta S, Grutzendler J. Neuron. 2015 Jul 1; 2015 Jun 25. PMID: 26119027.
• Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli.Housley WJ, Fernandez SD, Vera K, Murikinati SR, Grutzendler J, Cuerdon N, Glick L, De Jager PL, Mitrovic M, Cotsapas C, Hafler DA. Sci Transl Med. 2015 Jun 10. PMID: 26062845.
• Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques.Condello C, Yuan P, Schain A, Grutzendler J. Nat Commun. 2015 Jan 29; 2015 Jan 29. PMID: 25630253.
• In vivo imaging of oligodendrocytes with sulforhodamine 101.Hill RA, Grutzendler J. Nat Methods. 2014 Nov. PMID: 25357236.
• Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division.Hill RA, Patel KD, Goncalves CM, Grutzendler J, Nishiyama A. Nat Neurosci. 2014 Nov; 2014 Sep 28. PMID: 25262495.
• A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease.Zhang X, Tian Y, Yuan P, Li Y, Yaseen MA, Grutzendler J, Moore A, Ran C. Chem Commun (Camb). 2014 Oct 9. PMID: 25134928.
• Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy.Schain AJ, Hill RA, Grutzendler J. Nat Med. 2014 Apr; 2014 Mar 30. PMID: 24681598.
• Angiophagy prevents early embolus washout but recanalizes microvessels through embolus extravasation.Grutzendler J, Murikinati S, Hiner B, Ji L, Lam CK, Yoo T, Gupta S, Hafler BP, Adelman RA, Yuan P, Rodriguez G. Sci Transl Med. 2014 Mar 5. PMID: 24598589.
• Angiophagy: clearing or clogging microvessels?Iadecola C. Sci Transl Med. 2014 Mar 5. PMID: 24598587.
• Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period.Whiteus C, Freitas C, Grutzendler J. Nature. 2014 Jan 16; 2013 Dec 4. PMID: 24305053.
• Angiophagy: mechanism of microvascular recanalization independent of the fibrinolytic system.Grutzendler J. Stroke. 2013 Jun. PMID: 23709741.
• In vivo imaging of cerebral microvascular plasticity from birth to death.Harb R, Whiteus C, Freitas C, Grutzendler J. J Cereb Blood Flow Metab. 2013 Jan; 2012 Oct 24. PMID: 23093067.
• Transcranial two-photon imaging of the living mouse brain.Grutzendler J, Yang G, Pan F, Parkhurst CN, Gan WB. Cold Spring Harb Protoc. 2011 Sep 1; 2011 Sep 1. PMID: 21880826.
• Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition.Condello C, Schain A, Grutzendler J. Sci Rep. 2011; 2011 Jun 21. PMID: 22355538.
• CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis.Liu Z, Condello C, Schain A, Harb R, Grutzendler J. J Neurosci. 2010 Dec 15. PMID: 21159979.
• Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization.Lam CK, Yoo T, Hiner B, Liu Z, Grutzendler J. Nature. 2010 May 27. PMID: 20505729.
• Thinned-skull cranial window technique for long-term imaging of the cortex in live mice.Yang G, Pan F, Parkhurst CN, Grutzendler J, Gan WB. Nat Protoc. 2010 Feb; 2010 Jan 14. PMID: 20134419.
• Ballistic delivery of dyes for structural and functional studies of the nervous system.Gan WB, Grutzendler J, Wong RO, Lichtman JW. Cold Spring Harb Protoc. 2009 Apr. PMID: 20147144.
• Long-term two-photon transcranial imaging of synaptic structures in the living brain.Grutzendler J, Gan WB. CSH Protoc. 2007 Jul 1; 2007 Jul 1. PMID: 21357119.
• Various dendritic abnormalities are associated with fibrillar amyloid deposits in Alzheimer's disease.Grutzendler J, Helmin K, Tsai J, Gan WB. Ann N Y Acad Sci. 2007 Feb. PMID: 17413007.
• Two-photon imaging of synaptic plasticity and pathology in the living mouse brain.Grutzendler J, Gan WB. NeuroRx. 2006 Oct. PMID: 17012063.
• ATP mediates rapid microglial response to local brain injury in vivo.Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S, Littman DR, Dustin ML, Gan WB. Nat Neurosci. 2005 Jun; 2005 May 15. PMID: 15895084.
• Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches.Tsai J, Grutzendler J, Duff K, Gan WB. Nat Neurosci. 2004 Nov; 2004 Oct 10. PMID: 15475950.
• Age-associated synapse elimination in mouse parasympathetic ganglia.Coggan JS, Grutzendler J, Bishop DL, Cook MR, Gan W, Heym J, Lichtman JW. J Neurobiol. 2004 Aug. PMID: 15266652.
• Rapid labeling of neuronal populations by ballistic delivery of fluorescent dyes.Grutzendler J, Tsai J, Gan WB. Methods. 2003 May. PMID: 12695105.
• Long-term dendritic spine stability in the adult cortex.Grutzendler J, Kasthuri N, Gan WB. Nature. 2002 Dec 19-26. PMID: 12490949.
• Two modes of radial migration in early development of the cerebral cortex.Nadarajah B, Brunstrom JE, Grutzendler J, Wong RO, Pearlman AL. Nat Neurosci. 2001 Feb. PMID: 11175874.
• Cholinesterase inhibitors for Alzheimer's disease.Grutzendler J, Morris JC. Drugs. 2001. PMID: 11217870.
• Multicolor "DiOlistic" labeling of the nervous system using lipophilic dye combinations.Gan WB, Grutzendler J, Wong WT, Wong RO, Lichtman JW. Neuron. 2000 Aug. PMID: 10985343.