2001
Salmonella enterica Serovar Typhimurium Response Involved in Attenuation of Pathogen Intracellular Proliferation
Cano D, Martı́nez-Moya M, Pucciarelli M, Groisman E, Casadesús J, Portillo F. Salmonella enterica Serovar Typhimurium Response Involved in Attenuation of Pathogen Intracellular Proliferation. Infection And Immunity 2001, 69: 6463-6474. PMID: 11553591, PMCID: PMC98782, DOI: 10.1128/iai.69.10.6463-6474.2001.Peer-Reviewed Original ResearchConceptsIntracellular growth rateIntracellular bacterial viabilityIntracellular proliferation rateNormal rat kidney fibroblastsBacterial overgrowthNonphagocytic host cellsRat kidney fibroblastsNormal fibroblast cellsIntracellular bacterial proliferationMacrophage cellsIntracellular proliferationIntracellular bacteriaKidney fibroblastsVirulence genesFunction mutationsProliferation rateHost cellsBacterial proliferationSerovar TyphimuriumPhoP-PhoQ systemS. entericaProliferationCellsSalmonella enterica
2000
The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri
Moss J, Fisher P, Vick B, Groisman E, Zychlinsky A. The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri. Cellular Microbiology 2000, 2: 443-452. PMID: 11207599, DOI: 10.1046/j.1462-5822.2000.00065.x.Peer-Reviewed Original ResearchConceptsWild-type strainPhoP mutantPhoP/PhoQ systemTwo-component regulatory systemRegulatory protein PhoPHost cell phagosomesPhoP/PhoQKey virulence genesMutant bacteriaEnteric bacteriumPathogen escapeCell phagosomesHost cellsMutantsWild-type ShigellaPolymorphonuclear leucocytesRegulatory systemVirulence genesAntimicrobial moleculesAntimicrobial peptidesPhoPExtreme acidInflammatory responseEpithelial cellsPhagosomes