2000
Acetyl phosphate-dependent activation of a mutant PhoP response regulator that functions independently of its cognate sensor kinase11Edited by M. Gottesman
Chamnongpol S, Groisman E. Acetyl phosphate-dependent activation of a mutant PhoP response regulator that functions independently of its cognate sensor kinase11Edited by M. Gottesman. Journal Of Molecular Biology 2000, 300: 291-305. PMID: 10873466, DOI: 10.1006/jmbi.2000.3848.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAmino Acid SubstitutionBacterial ProteinsEnvironmentGene Expression Regulation, BacterialGenes, BacterialGenes, RegulatorMagnesiumMembrane ProteinsMethyl-Accepting Chemotaxis ProteinsModels, MolecularMutationOperonOrganophosphatesPhosphorylationProtein BindingProtein BiosynthesisProtein Structure, TertiaryRecombinant Fusion ProteinsSalmonella entericaTrans-ActivatorsTranscription, GeneticConceptsTranscription of PhoPResponse regulatorAcetyl phosphateResponse regulator receiver domainSites of phosphorylationVirulence gene expressionPhoP response regulatorTwo-component systemPhoQ proteinPhoP proteinReceiver domainSensor kinaseTranscriptional repressionCognate sensorMutant proteinsM. GottesmanPhosphorylated stateAspartate residueGene expressionPhoPTranscriptionPhosphate donorRegulatorProteinSalmonella enterica
1998
The ins and outs of virulence gene expression: Mg2+ as a regulatory signal
Groisman E. The ins and outs of virulence gene expression: Mg2+ as a regulatory signal. BioEssays 1998, 20: 96-101. PMID: 9504051, DOI: 10.1002/(sici)1521-1878(199801)20:1<96::aid-bies13>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsSignal transduction systemTransduction systemCellular locationPhoP/PhoQ systemPathogen Salmonella enterica serovar TyphimuriumIntracellular pathogen Salmonella enterica serovar TyphimuriumTranscription of genesPhoP/PhoQVirulence gene expressionFacultative intracellular pathogen Salmonella enterica serovar TyphimuriumSalmonella enterica serovar TyphimuriumDifferent cell typesRegulatory hierarchyEnterica serovar TyphimuriumRegulatory signalsExtracellular environmentGene expressionHost cellsHost cuesCell typesMultiple environmentsSerovar TyphimuriumPrecise tissuePhoQTranscription