2018
Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira
Adhikarla H, Wunder EA, Mechaly AE, Mehta S, Wang Z, Santos L, Bisht V, Diggle P, Murray G, Adler B, Lopez F, Townsend JP, Groisman E, Picardeau M, Buschiazzo A, Ko AI. Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira. Frontiers In Cellular And Infection Microbiology 2018, 8: 45. PMID: 29600195, PMCID: PMC5863495, DOI: 10.3389/fcimb.2018.00045.Peer-Reviewed Original ResearchConceptsResponse regulatorTwo-component system proteinsDNA-binding response regulatorGlobal transcriptional regulationHybrid histidine kinaseGlobal gene regulationNovel signal pathwayComprehensive genomic analysisPhosphotransfer assaysTCS genesHistidine kinaseGene duplicationTranscriptional regulationGene regulationCorresponding genesPhylogenetic analysisGenomic analysisMolecular basisMutant strainSystem proteinsSignaling systemInfection processGenesBranched pathwayVirulence
1995
Regulation of Salmonella Virulence by Two‐Component Regulatory Systems
Groisman E, Heffron F. Regulation of Salmonella Virulence by Two‐Component Regulatory Systems. 1995, 319-332. DOI: 10.1128/9781555818319.ch20.Peer-Reviewed Original ResearchTwo-component systemEnvZ/OmpR systemTwo-component regulatory systemClassical bacterial geneticsIdentification of lociPhoP/PhoQCrucial virulence factorTranscription regulatory factorsOuter membrane porins OmpCTissue culture model systemTranscriptional regulationBacterial geneticsVirulence defectBacterial pathogenesisMicrobial pathogenesisEnvironmental cuesCulture model systemSalmonella virulenceMutant strainRegulatory factorsPorins OmpCS. typhimuriumRegulatory systemVirulence determinantsAdaptive response
1994
The origin and evolution of species differences in Escherichia coli and Salmonella typhimurium
Ochman H, Groisman EA. The origin and evolution of species differences in Escherichia coli and Salmonella typhimurium. EXS 1994, 69: 479-493. PMID: 7994120, DOI: 10.1007/978-3-0348-7527-1_27.Peer-Reviewed Original ResearchConceptsSpecies-specific sequencesSalmonella chromosomeEscherichia coliCodon usage patternsOpen reading frameHost epithelial cellsCommon ancestorMap positionPhenotypic charactersReading frameBase compositionHorizontal transferSalmonella typhimuriumMutant strainGenetic differencesEnteric speciesBacterial speciesGenomePoint mutationsPhenotypic characteristicsSpeciesCorresponding regionChromosomesSpecies differencesEpithelial cells