2020
A Physiological Basis for Nonheritable Antibiotic Resistance
Pontes MH, Groisman EA. A Physiological Basis for Nonheritable Antibiotic Resistance. MBio 2020, 11: 10.1128/mbio.00817-20. PMID: 32546621, PMCID: PMC7298711, DOI: 10.1128/mbio.00817-20.Peer-Reviewed Original ResearchConceptsNonheritable resistanceAntibiotic toleranceCore cellular processesAcquisition of genesToxin-antitoxin modulesExpression of genesSlow bacterial growthActivity of toxinsAbility of bacteriaBacterial genomesCellular processesNutrient limitationBacterial growthGuanosine tetraphosphateGenetic changesBacterial populationsFeedback inhibitionPhysiological basisGenesOrganismsSmall subpopulationBacteriostatic antibioticsAntibiotic resistanceGenomeTolerance
2009
Short-Term Signatures of Evolutionary Change in the Salmonella enterica Serovar Typhimurium 14028 Genome
Jarvik T, Smillie C, Groisman EA, Ochman H. Short-Term Signatures of Evolutionary Change in the Salmonella enterica Serovar Typhimurium 14028 Genome. Journal Of Bacteriology 2009, 192: 560-567. PMID: 19897643, PMCID: PMC2805332, DOI: 10.1128/jb.01233-09.Peer-Reviewed Original ResearchConceptsComplete genomic sequenceGenomic sequencesSalmonella enterica serovar TyphimuriumTyphoid-like diseaseEnterica serovar TyphimuriumEvolutionary changeSequence evolutionGram-negative pathogensS. typhimuriumSerovar TyphimuriumComplete inventoryGenetic alterationsAvirulent strainsS. entericaPathogenic organismsSequenceLaboratory passageS. typhimurium strainTyphimuriumGenomeStrainsTyphimurium strainsLT2 strainOrganismsProgenitors
2000
Lateral gene transfer and the nature of bacterial innovation
Ochman H, Lawrence J, Groisman E. Lateral gene transfer and the nature of bacterial innovation. Nature 2000, 405: 299-304. PMID: 10830951, DOI: 10.1038/35012500.Peer-Reviewed Original ResearchConceptsLateral gene transferGene transferHorizontal gene transferBacterial innovationDynamic genomeGenetic diversityAcquisition of sequencesGenetic informationLateral transferBacterial speciesPathogenic characterEukaryotesGenomeChromosomesOrganismsSpeciesDNADiversityBacteriaSequenceSubstantial amount
1997
How Salmonella became a pathogen
Groisman E, Ochman H. How Salmonella became a pathogen. Trends In Microbiology 1997, 5: 343-349. PMID: 9294889, DOI: 10.1016/s0966-842x(97)01099-8.Peer-Reviewed Original Research
1994
The origin and evolution of species differences in Escherichia coli and Salmonella typhimurium
Ochman H, Groisman EA. The origin and evolution of species differences in Escherichia coli and Salmonella typhimurium. EXS 1994, 69: 479-493. PMID: 7994120, DOI: 10.1007/978-3-0348-7527-1_27.Peer-Reviewed Original ResearchConceptsSpecies-specific sequencesSalmonella chromosomeEscherichia coliCodon usage patternsOpen reading frameHost epithelial cellsCommon ancestorMap positionPhenotypic charactersReading frameBase compositionHorizontal transferSalmonella typhimuriumMutant strainGenetic differencesEnteric speciesBacterial speciesGenomePoint mutationsPhenotypic characteristicsSpeciesCorresponding regionChromosomesSpecies differencesEpithelial cells
1992
Horizontal transfer of a phosphatase gene as evidence for mosaic structure of the Salmonella genome.
Groisman EA, Saier MH, Ochman H. Horizontal transfer of a phosphatase gene as evidence for mosaic structure of the Salmonella genome. The EMBO Journal 1992, 11: 1309-1316. PMID: 1339343, PMCID: PMC556579, DOI: 10.1002/j.1460-2075.1992.tb05175.x.Peer-Reviewed Original ResearchMeSH KeywordsAcid PhosphataseAmino Acid SequenceBase CompositionBase SequenceChromosomes, BacterialCloning, MolecularCodonDNAEscherichia coliGenes, BacterialGenome, BacterialMolecular Sequence DataMosaicismPhylogenyPlasmidsRestriction MappingSalmonella typhimuriumSequence Homology, Nucleic AcidTransfectionConceptsBase compositionPhoN geneNon-specific acid phosphatase activityAtypical base compositionSpacing of genesOverall base compositionNon-specific acid phosphataseCodon usage patternsGram-negative speciesChromosome sizeBacterial genomesPhosphatase geneKb regionSalmonella chromosomeSalmonella genomeGenetic basisHorizontal transferAcid phosphatase activityTrinucleotide frequenciesHigh similarityGenomeGenesEscherichia coliPhosphatase activityOriT regionMolecular genetic analysis of the Escherichia coli phoP locus
Groisman EA, Heffron F, Solomon F. Molecular genetic analysis of the Escherichia coli phoP locus. Journal Of Bacteriology 1992, 174: 486-491. PMID: 1530848, PMCID: PMC205741, DOI: 10.1128/jb.174.2.486-491.1992.Peer-Reviewed Original ResearchConceptsDeduced amino acid sequenceIsogenic wild-type strainE. coli genomePhoP geneMajor virulence regulatorAmino acid sequenceWild-type strainTwo-component systemMolecular genetic analysisColi genomePhoP locusVirulence regulatorIntramacrophage survivalAcid sequenceGenetic analysisEnteric speciesPhoP mutantE. coliGenesMagainin 2Cationic peptidesPhagocytic cellsGenomeHomologMutants