2020
A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor
Townsend GE, Han W, Schwalm ND, Hong X, Bencivenga-Barry NA, Goodman AL, Groisman EA. A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor. MBio 2020, 11: 10.1128/mbio.03221-19. PMID: 31992627, PMCID: PMC6989115, DOI: 10.1128/mbio.03221-19.Peer-Reviewed Original ResearchPutative translation factorProtein synthesis factorsTranslation factorsMammalian gutDietary fiber utilizationTranscriptional regulatorsBeneficial microbesSpecialized translation factorHundreds of genesMajor transcriptional regulatorGut colonizationCarbohydrate utilizationSynthesis factorsHuman gut microbiotaGlobal regulonGenetic repertoireTranscription factorsMaster regulatorDNA sequencesDerive nutrientsColonization defectUtilization of carbohydratesCellular metabolismComplex polysaccharidesGenes
2016
Multiple Signals Govern Utilization of a Polysaccharide in the Gut Bacterium Bacteroides thetaiotaomicron
Schwalm ND, Townsend GE, Groisman EA. Multiple Signals Govern Utilization of a Polysaccharide in the Gut Bacterium Bacteroides thetaiotaomicron. MBio 2016, 7: 10.1128/mbio.01342-16. PMID: 27729509, PMCID: PMC5061871, DOI: 10.1128/mbio.01342-16.Peer-Reviewed Original ResearchConceptsMammalian gut microbiotaPolysaccharide utilization genesUtilization genesHost dietGut symbiont Bacteroides thetaiotaomicronComplex polysaccharidesBacteroides thetaiotaomicronPleiotropic transcriptional regulatorDomains of lifeSubset of organismsRegulatory paradigmCritical nutrient sourceTranscriptional activatorTranscriptional regulatorsTranscriptional repressorCentral metabolismGenomic analysisMammalian gutMammalian hostsRegulatory architectureGut BacteroidesPolymeric fructanGut microbiotaGut bacteriumPolysaccharide breakdown