Publications

2025

Nuclear polarization to the immune synapse facilitates an early transcriptional burst
Asano Y, Ma C, Limback-Stokin M, Rochussen A, Stinchcombe J, Griffiths G. Nuclear polarization to the immune synapse facilitates an early transcriptional burst. Science Immunology 2025, 10: eadt5909. PMID: 40971450, DOI: 10.1126/sciimmunol.adt5909.
Peer-Reviewed Original Research
MeSH Keywords
Transcriptional adaptation after deletion of Cdc42 in primary T cells
Rochussen A, Y. C, Griffiths G. Transcriptional adaptation after deletion of Cdc42 in primary T cells. Journal Of Cell Science 2025, 138: jcs263826. PMID: 40613419, PMCID: PMC12377712, DOI: 10.1242/jcs.263826.
Peer-Reviewed Original Research

2024

The MYO1F interactome reveals ASAP1, CD2AP and SH3KBP1 as novel adaptor proteins in podosomes and phagosomes
Arden S, Pennink E, Lakatos A, Griffiths G, Lippert A, Buss F. The MYO1F interactome reveals ASAP1, CD2AP and SH3KBP1 as novel adaptor proteins in podosomes and phagosomes. Journal Of Cell Science 2024, 138: jcs264357. PMID: 41208482, PMCID: PMC12772958, DOI: 10.1242/jcs.264357.
Peer-Reviewed Original Research
MeSH Keywords
Dominant negative variants in ITPR3 impair T cell Ca2+ dynamics causing combined immunodeficiency
Blanco E, Camps C, Bahal S, Kerai M, Ferla M, Rochussen A, Handel A, Golwala Z, Goncalves H, Kricke S, Klein F, Zhang F, Zinghirino F, Evans G, Keane T, Lizot S, Kusters M, Iro M, Patel S, Morris E, Burns S, Radcliffe R, Vasudevan P, Price A, Gillham O, Valdebenito G, Stewart G, Worth A, Adams S, Duchen M, André I, Adams D, Santili G, Gilmour K, Holländer G, Davies E, Taylor J, Griffiths G, Thrasher A, Dhalla F, Kreins A. Dominant negative variants in ITPR3 impair T cell Ca2+ dynamics causing combined immunodeficiency. Journal Of Experimental Medicine 2024, 222: e20220979. PMID: 39560673, PMCID: PMC11577440, DOI: 10.1084/jem.20220979.
Peer-Reviewed Original Research
MeSH Keywords
NFIL3 contributes to cytotoxic T lymphocyte-mediated killing
Douanne T, Strege K, Del Castillo Velasco-Herrera M, Rochussen A, Adams D, Griffiths G. NFIL3 contributes to cytotoxic T lymphocyte-mediated killing. Open Biology 2024, 14: 230456. PMID: 38412963, PMCID: PMC10898977, DOI: 10.1098/rsob.230456.
Peer-Reviewed Original Research
MeSH Keywords

2023

Cytotoxic T lymphocytes require transcription for infiltration but not target cell lysis
Richard A, Ma C, Marioni J, Griffiths G. Cytotoxic T lymphocytes require transcription for infiltration but not target cell lysis. EMBO Reports 2023, 24: embr202357653. PMID: 37860838, PMCID: PMC10626425, DOI: 10.15252/embr.202357653.
Peer-Reviewed Original Research
MeSH Keywords
Immunodeficiency with susceptibility to lymphoma with complex genotype affecting energy metabolism (FBP1, ACAD9) and vesicle trafficking (RAB27A)
Brauer N, Maruta Y, Lisci M, Strege K, Oschlies I, Nakamura H, Böhm S, Lehmberg K, Brandhoff L, Ehl S, Parvaneh N, Klapper W, Fukuda M, Griffiths G, Hennies H, Niehues T, Ammann S. Immunodeficiency with susceptibility to lymphoma with complex genotype affecting energy metabolism (FBP1, ACAD9) and vesicle trafficking (RAB27A). Frontiers In Immunology 2023, 14: 1151166. PMID: 37388727, PMCID: PMC10303925, DOI: 10.3389/fimmu.2023.1151166.
Peer-Reviewed Original Research
MeSH Keywords
Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse
Stinchcombe J, Asano Y, Kaufman C, Bohlig K, Peddie C, Collinson L, Nadler A, Griffiths G. Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse. Science 2023, 380: 818-823. PMID: 37228189, PMCID: PMC7614748, DOI: 10.1126/science.abp8933.
Peer-Reviewed Original Research
MeSH Keywords
Imaging the T-cell receptor: new approaches, new insights
Rochussen A, Lippert A, Griffiths G. Imaging the T-cell receptor: new approaches, new insights. Current Opinion In Immunology 2023, 82: 102309. PMID: 37011462, DOI: 10.1016/j.coi.2023.102309.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords
Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy
Trefny M, Kirchhammer N, Auf der Maur P, Natoli M, Schmid D, Germann M, Fernandez Rodriguez L, Herzig P, Lötscher J, Akrami M, Stinchcombe J, Stanczak M, Zingg A, Buchi M, Roux J, Marone R, Don L, Lardinois D, Wiese M, Jeker L, Bentires-Alj M, Rossy J, Thommen D, Griffiths G, Läubli H, Hess C, Zippelius A. Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy. Nature Communications 2023, 14: 86. PMID: 36732507, PMCID: PMC9895440, DOI: 10.1038/s41467-022-35583-w.
Peer-Reviewed Original Research
MeSH Keywords

2022

Super‐killer CTLs are generated by single gene deletion of Bach2
Barton P, Davenport A, Hukelmann J, Cantrell D, Stinchcombe J, Richard A, Griffiths G. Super‐killer CTLs are generated by single gene deletion of Bach2. European Journal Of Immunology 2022, 52: 1776-1788. PMID: 36086884, PMCID: PMC9828676, DOI: 10.1002/eji.202249797.
Peer-Reviewed Original Research
MeSH Keywords
Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity
Lisci M, Griffiths G. Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity. Trends In Cell Biology 2022, 33: 138-147. PMID: 35753961, DOI: 10.1016/j.tcb.2022.05.007.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords

2021

Mitochondrial translation is required for sustained killing by cytotoxic T cells
Lisci M, Barton P, Randzavola L, Ma C, Marchingo J, Cantrell D, Paupe V, Prudent J, Stinchcombe J, Griffiths G. Mitochondrial translation is required for sustained killing by cytotoxic T cells. Science 2021, 374: eabe9977. PMID: 34648346, DOI: 10.1126/science.abe9977.
Peer-Reviewed Original Research
MeSH Keywords
Staggered starts in the race to T cell activation
Richard A, Frazer G, Y. C, Griffiths G. Staggered starts in the race to T cell activation. Trends In Immunology 2021, 42: 994-1008. PMID: 34649777, PMCID: PMC7612485, DOI: 10.1016/j.it.2021.09.004.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords
Signal strength controls the rate of polarization within CTLs during killing
Frazer G, Gawden-Bone C, Dieckmann N, Asano Y, Griffiths G. Signal strength controls the rate of polarization within CTLs during killing. Journal Of Cell Biology 2021, 220: e202104093. PMID: 34292303, PMCID: PMC8302442, DOI: 10.1083/jcb.202104093.
Peer-Reviewed Original Research
MeSH Keywords
Teasing out function from morphology: Similarities between primary cilia and immune synapses
Douanne T, Stinchcombe J, Griffiths G. Teasing out function from morphology: Similarities between primary cilia and immune synapses. Journal Of Cell Biology 2021, 220: e202102089. PMID: 33956049, PMCID: PMC8105739, DOI: 10.1083/jcb.202102089.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords
Cytoskeletal control of the secretory immune synapse
Douanne T, Griffiths G. Cytoskeletal control of the secretory immune synapse. Current Opinion In Cell Biology 2021, 71: 87-94. PMID: 33711784, DOI: 10.1016/j.ceb.2021.02.008.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords

2020

2019

High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation
Abeler-Dörner L, Laing A, Lorenc A, Ushakov D, Clare S, Speak A, Duque-Correa M, White J, Ramirez-Solis R, Saran N, Bull K, Morón B, Iwasaki J, Barton P, Caetano S, Hng K, Cambridge E, Forman S, Crockford T, Griffiths M, Kane L, Harcourt K, Brandt C, Notley G, Babalola K, Warren J, Mason J, Meeniga A, Karp N, Melvin D, Cawthorne E, Weinrick B, Rahim A, Drissler S, Meskas J, Yue A, Lux M, Song-Zhao G, Chan A, Ballesteros Reviriego C, Abeler J, Wilson H, Przemska-Kosicka A, Edmans M, Strevens N, Pasztorek M, Meehan T, Powrie F, Brinkman R, Dougan G, Jacobs W, Lloyd C, Cornall R, Maloy K, Grencis R, Griffiths G, Adams D, Hayday A. High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature Immunology 2019, 21: 86-100. PMID: 31844327, PMCID: PMC7338221, DOI: 10.1038/s41590-019-0549-0.
Peer-Reviewed Original Research
MeSH Keywords
Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity
Randzavola L, Strege K, Juzans M, Asano Y, Stinchcombe J, Gawden-Bone C, Seaman M, Kuijpers T, Griffiths G. Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity. Journal Of Clinical Investigation 2019, 129: 5600-5614. PMID: 31710310, PMCID: PMC6877333, DOI: 10.1172/jci129388.
Peer-Reviewed Original Research
MeSH Keywords
Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse
Gawden-Bone C, Griffiths G. Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse. Frontiers In Immunology 2019, 10: 700. PMID: 31031745, PMCID: PMC6470250, DOI: 10.3389/fimmu.2019.00700.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords

See All Publications

Publications

2025

Nuclear polarization to the immune synapse facilitates an early transcriptional burst

Transcriptional adaptation after deletion of Cdc42 in primary T cells

2024

The MYO1F interactome reveals ASAP1, CD2AP and SH3KBP1 as novel adaptor proteins in podosomes and phagosomes

Dominant negative variants in ITPR3 impair T cell Ca2+ dynamics causing combined immunodeficiency

NFIL3 contributes to cytotoxic T lymphocyte-mediated killing

2023

Cytotoxic T lymphocytes require transcription for infiltration but not target cell lysis

Immunodeficiency with susceptibility to lymphoma with complex genotype affecting energy metabolism (FBP1, ACAD9) and vesicle trafficking (RAB27A)

Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse

Imaging the T-cell receptor: new approaches, new insights

Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy

2022

Super‐killer CTLs are generated by single gene deletion of Bach2

Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity

2021

Mitochondrial translation is required for sustained killing by cytotoxic T cells

Staggered starts in the race to T cell activation

Signal strength controls the rate of polarization within CTLs during killing

Teasing out function from morphology: Similarities between primary cilia and immune synapses

Cytoskeletal control of the secretory immune synapse

2020

Griscelli Syndrome Type 2 Sine Albinism: Unraveling Differential RAB27A Effector Engagement

A new direction for Traffic

Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling

Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy

2019

High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity

Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse

2018

PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes