Nuclear polarization to the immune synapse facilitates an early transcriptional burst
Asano Y, Ma C, Limback-Stokin M, Rochussen A, Stinchcombe J, Griffiths G. Nuclear polarization to the immune synapse facilitates an early transcriptional burst. Science Immunology 2025, 10: eadt5909. PMID: 40971450, DOI: 10.1126/sciimmunol.adt5909.Peer-Reviewed Original Research
ConceptsCytotoxic T lymphocytesTarget cell recognitionTranscription factor translocationImmune synapseIndividual cytotoxic T lymphocyteCTL-mediated killingCell recognitionTranscription factor NFATT lymphocytesCytolytic granulesTCR activationNF-kBNuclear polarizationTranscriptional burstingDe novo transcriptionSynapseCentrosome dockingDeliveryMyosin IIANucleusTranscriptionTranslocation