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Biography
Krupa Jani, MD, PhD, is an instructor of clinical therapeutic radiology. Dr. Jani completed her residency training at Yale, where she served as a chief resident 2025-2026. Her clinical practice will focus on breast, genitourinary, head and neck, and CNS malignancies, while her research interests are focused on understanding chromatin and epigenetics in the context of cancer and cancer therapies.
Hometown: Rockaway, NJ.
Research Interests: Epigenetics, chromatin modifying enzymes, chromatin structure and repair, radiosensitizers.
Last Updated on July 27, 2026.
Appointments
Therapeutic Radiology
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Education & Training
- Residency - Radiation Oncology
- Yale School of Medicine (2026)
- Internship - General Surgery
- Robert Wood Johnson Medical School/Rutgers University (2022)
- MD
- Rutgers University Robert Wood Johnson Medical School (2021)
- PhD
- Princeton University, Molecular Biology (2019)
- BS
- The College of New Jersey, Biology (2011)
Research
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Overview
Dr. Jani conducts research on understanding the role of epigenetics in cancer progression, particularly in the context of DNA and chromatin damage and repair.
ORCID
0000-0002-3103-4575
Research at a Glance
Publications Timeline
A big-picture view of Krupa Jani's research output by year.
7Publications
595Citations
Publications
2021
Malignancies diagnosed before and after anal squamous cell carcinomas: A SEER registry analysis
Jani K, Lu S, Murphy J, Romesser P, Jethwa K, Li D, Chundury A, Wu A, Hathout L, Hallemeier C, Jabbour S. Malignancies diagnosed before and after anal squamous cell carcinomas: A SEER registry analysis. Cancer Medicine 2021, 10: 3575-3583. PMID: 33960690, PMCID: PMC8178496, DOI: 10.1002/cam4.3909.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords
2020
The Evolving Role of Radiotherapy in Locally Advanced Rectal Cancer and the Potential for Nonoperative Management
Khullar K, Patel N, Anderson C, Chundury A, Carpizo D, Feingold D, Grandhi M, Hochster H, Jani K, Kennedy T, Langan R, Spencer K, August D, Jabbour S, Department of Radiation Oncology R, Department of Surgery R, Division of Surgical Oncology R, Division of Medical Oncology R. The Evolving Role of Radiotherapy in Locally Advanced Rectal Cancer and the Potential for Nonoperative Management. TouchREVIEWS In Oncology & Haematology 2020, 16: 43. PMID: 32832093, PMCID: PMC7439775, DOI: 10.17925/ohr.2020.16.1.43.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitations
2019
PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor
Diehl K, Ge E, Weinberg D, Jani K, Allis C, Muir T. PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 22152-22157. PMID: 31611394, PMCID: PMC6825254, DOI: 10.1073/pnas.1911775116.Peer-Reviewed Original ResearchCitationsAltmetricNucleation and Propagation of Heterochromatin by the Histone Methyltransferase PRC2: Geometric Constraints and Impact of the Regulatory Subunit JARID2
Ge E, Jani K, Diehl K, Müller M, Muir T. Nucleation and Propagation of Heterochromatin by the Histone Methyltransferase PRC2: Geometric Constraints and Impact of the Regulatory Subunit JARID2. Journal Of The American Chemical Society 2019, 141: 15029-15039. PMID: 31479253, PMCID: PMC6941475, DOI: 10.1021/jacs.9b02321.Peer-Reviewed Original ResearchCitationsAltmetricHistone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase
Jani K, Jain S, Ge E, Diehl K, Lundgren S, Müller M, Lewis P, Muir T. Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 8295-8300. PMID: 30967505, PMCID: PMC6486736, DOI: 10.1073/pnas.1819029116.Peer-Reviewed Original ResearchCitationsAltmetric
2016
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
Lu C, Jain SU, Hoelper D, Bechet D, Molden RC, Ran L, Murphy D, Venneti S, Hameed M, Pawel BR, Wunder JS, Dickson BC, Lundgren SM, Jani KS, De Jay N, Papillon-Cavanagh S, Andrulis IL, Sawyer SL, Grynspan D, Turcotte RE, Nadaf J, Fahiminiyah S, Muir TW, Majewski J, Thompson CB, Chi P, Garcia BA, Allis CD, Jabado N, Lewis PW. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science 2016, 352: 844-849. PMID: 27174990, PMCID: PMC4928577, DOI: 10.1126/science.aac7272.Peer-Reviewed Original ResearchCitationsAltmetric
2012
Computational Design of Targeted Inhibitors of Polo-Like Kinase 1 (Plk1)
Jani K, Dalafave D. Computational Design of Targeted Inhibitors of Polo-Like Kinase 1 (Plk1). Bioinformatics And Biology Insights 2012, 6: bbi.s8971. PMID: 22399850, PMCID: PMC3290105, DOI: 10.4137/bbi.s8971.Peer-Reviewed Original ResearchCitationsAltmetric
Clinical Care
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Clinical Specialties
Therapeutic Radiology
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