Publications

2026

Nonaddictive Analgesia: New Approaches That Target the Hodgkin-Huxley NaV/KV Dyad.
Tyagi S, Ghovanloo M, Estacion M, Dib-Hajj S, Waxman S. Nonaddictive Analgesia: New Approaches That Target the Hodgkin-Huxley NaV/KV Dyad. The Annual Review Of Pharmacology And Toxicology 2026 PMID: 42594287, DOI: 10.1146/annurev-pharmtox-060325-034103.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Matching sodium channel availability to resting membrane potential: Biophysical logic across excitable cell types
Ghovanloo M, Waxman S. Matching sodium channel availability to resting membrane potential: Biophysical logic across excitable cell types. The Journal Of Physiology 2026, 604: 3738-3762. PMID: 41923350, DOI: 10.1113/jp290383.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords
Nav1.8 Variant I206M as a Latent Susceptibility Factor in Postaxotomy Ocular Pain
Ghovanloo M, Effraim P, Tyagi S, Aldrich A, Yuan J, Schulman B, Jacobs D, Dib-Hajj S, Waxman S. Nav1.8 Variant I206M as a Latent Susceptibility Factor in Postaxotomy Ocular Pain. Neurology Genetics 2026, 12: e200367. PMID: 41868096, PMCID: PMC13004580, DOI: 10.1212/nxg.0000000000200367.
Peer-Reviewed Original Research

2025

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
Alexander S, Striessnig J, Gibb A, Mathie A, Veale E, Kelly E, Peach C, Armstrong J, Faccenda E, Harding S, Southan C, Davies J, Aldrich R, Attali B, Baggetta A, Becirovic E, Beech D, Biel M, Bill R, Caceres A, Catterall W, Chua H, Conner A, Danahay H, Davies P, De Clerq K, Delling M, Di Virgilio F, Falzoni S, Fang W, Fenske S, Fortuny-Gomez A, Fountain S, Chandy G, Ghovanloo M, Goldstein S, Gosling M, Grimm C, Grissmer S, Ha K, Hales T, Hammelmann V, Hanukoglu I, Hu M, Ijzerman A, Jabba S, Jarvis M, Jensen A, Jordt S, Kaczmarek L, Kellenberger S, Kennedy C, King B, Kitchen P, Liu Q, Lynch J, Manville R, Meades J, Mehlfeld V, Nicke A, Offermanns S, Pérez-Reyes E, Plant L, Pless S, Rash L, Ren D, Rubaiy H, Salman M, Sieghart W, Sivilotti L, Smart T, Snutch T, Tammaro P, Tian J, Trimmer J, Van den Eynde C, Vergani P, Vriens J, Waxman S, Wei A, Winn B, Wulff H, Xu H, Yang F, Yue L, Zhang X, Zhu M. The Concise Guide to PHARMACOLOGY 2025/26: Ion channels. British Journal Of Pharmacology 2025, 182: s152-s241. PMID: 41461580, DOI: 10.1111/bph.70231.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords
Voltage-gated sodium channels (NaV) in GtoPdb v.2025.4
Catterall W, Ghovanloo M, Goldin A, Waxman S. Voltage-gated sodium channels (NaV) in GtoPdb v.2025.4. IUPHAR/BPS Guide To Pharmacology CITE 2025, 2025 DOI: 10.2218/gtopdb/f82/2025.4.
Peer-Reviewed Original Research
Differential contribution of α2δ auxiliary subunits of voltage-gated calcium channels in mouse models of pain and itch
Braz J, Jewell M, Bhardwaj K, Rodriguez-Rosado S, Craik V, Basbaum A. Differential contribution of α2δ auxiliary subunits of voltage-gated calcium channels in mouse models of pain and itch. PLOS ONE 2025, 20: e0337701. PMID: 41329670, PMCID: PMC12671734, DOI: 10.1371/journal.pone.0337701.
Peer-Reviewed Original Research
MeSH Keywords
Contribution of transmembrane channel-like (TMC) proteins 3, 5 and 7 to pain and itch processing
Braz J, Bhardwaj K, Rodriguez-Rosado S, Jewell M, Craik V, Basbaum A. Contribution of transmembrane channel-like (TMC) proteins 3, 5 and 7 to pain and itch processing. Journal Of Pain 2025, 38: 105593. PMID: 41207409, PMCID: PMC13470996, DOI: 10.1016/j.jpain.2025.105593.
Peer-Reviewed Original Research
MeSH Keywords
SCN3A-related neurodevelopmental disorder: Clinical case reports and biophysical characterization
Ghovanloo M, Gershome C, van der Lee R, Drogemoller B, Zhang L, Matthews A, Blydt-Hansen I, Nikkel S, Demos M, Wasserman W, Ross C, van Karnebeek C, Ruben P. SCN3A-related neurodevelopmental disorder: Clinical case reports and biophysical characterization. Channels 2025, 19: 2580175. PMID: 41165134, PMCID: PMC12578310, DOI: 10.1080/19336950.2025.2580175.
Peer-Reviewed Original Research
MeSH Keywords
Voltage-gated sodium channels (NaV) in GtoPdb v.2025.3
Catterall W, Ghovanloo M, Goldin A, Waxman S. Voltage-gated sodium channels (NaV) in GtoPdb v.2025.3. IUPHAR/BPS Guide To Pharmacology CITE 2025, 2025 DOI: 10.2218/gtopdb/f82/2025.3.
Peer-Reviewed Original Research
Paradoxical increases in anterior cingulate cortex activity during nitrous oxide–induced analgesia reveal a signature of pain affect
Weinrich J, Liu C, Jewell M, Andolina C, Bernstein M, Benitez J, Rodriguez-Rosado S, Braz J, Maze M, Nemenov M, Basbaum A. Paradoxical increases in anterior cingulate cortex activity during nitrous oxide–induced analgesia reveal a signature of pain affect. Pain 2025, 166: 2576-2587. PMID: 41037432, DOI: 10.1097/j.pain.0000000000003771.
Peer-Reviewed Original Research
MeSH Keywords
Enhanced trafficking of an inherited erythromelalgia NaV1.7 mutant channel at a physiological temperature
Mis M, Tyagi S, Akin E, Ghovanloo M, Zhao P, Dib-Hajj F, Randall A, Waxman S, Dib-Hajj S. Enhanced trafficking of an inherited erythromelalgia NaV1.7 mutant channel at a physiological temperature. Neurobiology Of Pain 2025, 18: 100188. PMID: 40606587, PMCID: PMC12221430, DOI: 10.1016/j.ynpai.2025.100188.
Peer-Reviewed Original Research
High-throughput multiplex voltage-clamp/current-clamp evaluation of acutely isolated neurons
Ghovanloo M, Tyagi S, Zhao P, Kiziltug E, Estacion M, Effraim P, Dib-Hajj S, Waxman S. High-throughput multiplex voltage-clamp/current-clamp evaluation of acutely isolated neurons. Nature Protocols 2025, 21: 609-634. PMID: 40514421, PMCID: PMC13037423, DOI: 10.1038/s41596-025-01194-0.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Keratinocyte–TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch
A.J. Crowther,S.W. Kashem,M.E. Jewell,H. Le Chang,É. Midavaine,M. Rosa Casillas,V. Danchine,S. Rodriguez,A. Kania,R. Chen,J.M. Braz,& A.I. Basbaum, Keratinocyte–TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch, Proc. Natl. Acad. Sci. U.S.A. 122 (24) e2411724122, https://doi.org/10.1073/pnas.2411724122 (2025).
Peer-Reviewed Original Research In Press
Keratinocyte–TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch
Crowther A, Kashem S, Jewell M, Le Chang H, Midavaine É, Casillas M, Danchine V, Rodriguez S, Kania A, Chen R, Braz J, Basbaum A. Keratinocyte–TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2411724122. PMID: 40498457, PMCID: PMC12184494, DOI: 10.1073/pnas.2411724122.
Peer-Reviewed Original Research
MeSH Keywords
Brain stimulation enhances dispositional mindfulness in PTSD: an exploratory sham-controlled rTMS trial
Rayani K, Grabovac A, Chan P, Montgomery S, Ghovanloo M, Sacchet M. Brain stimulation enhances dispositional mindfulness in PTSD: an exploratory sham-controlled rTMS trial. Frontiers In Psychiatry 2025, 16: 1494567. PMID: 40365001, PMCID: PMC12069409, DOI: 10.3389/fpsyt.2025.1494567.
Peer-Reviewed Original Research
In vitro inhibition of voltage-dependent sodium currents by the antifungal drug amorolfine
Ghovanloo M, Tyagi S, Effraim P, Waxman S. In vitro inhibition of voltage-dependent sodium currents by the antifungal drug amorolfine. Journal Of Biological Chemistry 2025, 301: 108407. PMID: 40090585, PMCID: PMC12004706, DOI: 10.1016/j.jbc.2025.108407.
Peer-Reviewed Original Research
Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids
Ghovanloo M, Tyagi S, Zhao P, Waxman S. Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2416886122. PMID: 39835903, PMCID: PMC11789019, DOI: 10.1073/pnas.2416886122.
Peer-Reviewed Original Research
MeSH Keywords

2024

The evolution of patch-clamp electrophysiology: Robotic, multiplex, and dynamic
Ghovanloo M, Dib-Hajj S, Waxman S. The evolution of patch-clamp electrophysiology: Robotic, multiplex, and dynamic. Molecular Pharmacology 2024, 107: 100001. PMID: 39919159, PMCID: PMC13012292, DOI: 10.1124/molpharm.124.000954.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
TRPM8 Mutations Associated With Persistent Pain After Surgical Injury of Corneal Trigeminal Axons
Ghovanloo M, Effraim P, Tyagi S, Aldrich A, Cheng X, Yuan J, Schulman B, Jacobs D, Dib-Hajj S, Waxman S. TRPM8 Mutations Associated With Persistent Pain After Surgical Injury of Corneal Trigeminal Axons. Neurology Genetics 2024, 10: e200206. PMID: 39555137, PMCID: PMC11567650, DOI: 10.1212/nxg.0000000000200206.
Peer-Reviewed Original Research
Impacts of resident physician unionization on house staff compensation
Tyagi S, Shah R, Huttler J, Kayani J, Ghovanloo M, Effraim P. Impacts of resident physician unionization on house staff compensation. PLOS ONE 2024, 19: e0308100. PMID: 39361626, PMCID: PMC11449312, DOI: 10.1371/journal.pone.0308100.
Peer-Reviewed Original Research
MeSH Keywords
Molecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo
Goodchild S, Shuart N, Williams A, Ye W, Parrish R, Soriano M, Thouta S, Mezeyova J, Waldbrook M, Dean R, Focken T, Ghovanloo M, Ruben P, Scott F, Cohen C, Empfield J, Johnson J. Molecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo. ACS Chemical Neuroscience 2024, 15: 1169-1184. PMID: 38359277, PMCID: PMC10958515, DOI: 10.1021/acschemneuro.3c00757.
Peer-Reviewed Original Research
Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol
Ghovanloo M, Effraim P, Tyagi S, Zhao P, Dib-Hajj S, Waxman S. Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol. Communications Biology 2024, 7: 120. PMID: 38263462, PMCID: PMC10805714, DOI: 10.1038/s42003-024-05781-x.
Peer-Reviewed Original Research
MeSH Keywords
Compartment-specific regulation of NaV1.7 in sensory neurons after acute exposure to TNF-α
Tyagi S, Higerd-Rusli G, Ghovanloo M, Dib-Hajj F, Zhao P, Liu S, Kim D, Shim J, Park K, Waxman S, Choi J, Dib-Hajj S. Compartment-specific regulation of NaV1.7 in sensory neurons after acute exposure to TNF-α. Cell Reports 2024, 43: 113685. PMID: 38261513, PMCID: PMC10947185, DOI: 10.1016/j.celrep.2024.113685.
Peer-Reviewed Original Research

2023

Sodium currents in naïve mouse dorsal root ganglion neurons: No major differences between sexes
Ghovanloo M, Tyagi S, Zhao P, Effraim P, Dib-Hajj S, Waxman S. Sodium currents in naïve mouse dorsal root ganglion neurons: No major differences between sexes. Channels 2023, 18: 2289256. PMID: 38055732, PMCID: PMC10761158, DOI: 10.1080/19336950.2023.2289256.
Peer-Reviewed Original Research
MeSH Keywords
Docking for EP4R antagonists active against inflammatory pain
Gahbauer S, DeLeon C, Braz J, Craik V, Kang H, Wan X, Huang X, Billesbølle C, Liu Y, Che T, Deshpande I, Jewell M, Fink E, Kondratov I, Moroz Y, Irwin J, Basbaum A, Roth B, Shoichet B. Docking for EP4R antagonists active against inflammatory pain. Nature Communications 2023, 14: 8067. PMID: 38057319, PMCID: PMC10700596, DOI: 10.1038/s41467-023-43506-6.
Peer-Reviewed Original Research
MeSH Keywords

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