2022
Endothelial Cell TGF-β (Transforming Growth Factor-Beta) Signaling Regulates Venous Adaptive Remodeling to Improve Arteriovenous Fistula Patency
Taniguchi R, Ohashi Y, Lee JS, Hu H, Gonzalez L, Zhang W, Langford J, Matsubara Y, Yatsula B, Tellides G, Fahmy TM, Hoshina K, Dardik A. Endothelial Cell TGF-β (Transforming Growth Factor-Beta) Signaling Regulates Venous Adaptive Remodeling to Improve Arteriovenous Fistula Patency. Arteriosclerosis Thrombosis And Vascular Biology 2022, 42: 868-883. PMID: 35510552, PMCID: PMC9233042, DOI: 10.1161/atvbaha.122.317676.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaSMC proliferationAVF patencyCollagen densityMouse aortocaval fistula modelTGF-β receptor IArteriovenous fistula patencyAortocaval fistula modelInhibition of TGFPredetermined time pointsTGF-β inhibitionTGF-β signalingTGF-β receptorDisruption of TGFFistula patencyAVF failureWall thicknessVascular accessVenous remodelingSuccessful hemodialysisDoppler ultrasoundFistula modelReceptor IPatencyTGF
2020
Altered hemodynamics during arteriovenous fistula remodeling leads to reduced fistula patency in female mice
Kudze T, Ono S, Fereydooni A, Gonzalez L, Isaji T, Hu H, Yatsula B, Taniguchi R, Koizumi J, Nishibe T, Dardik A. Altered hemodynamics during arteriovenous fistula remodeling leads to reduced fistula patency in female mice. JVS Vascular Science 2020, 1: 42-56. PMID: 32754721, PMCID: PMC7402599, DOI: 10.1016/j.jvssci.2020.03.001.Peer-Reviewed Original ResearchInfrarenal inferior vena cavaArteriovenous fistulaFemale miceMale miceHuman AVF maturationAVF maturationAVF patencyVascular cell adhesion molecule-1Superior long-term outcomesEndothelial nitric oxide synthaseCell adhesion molecule-1Male C57BL/6 miceLong-term outcomesInferior vena cavaNitric oxide synthaseAdhesion molecule-1Krüppel-like factor 2Significant differencesSex-specific differential expressionMessenger RNAAVF remodelingAVF utilizationFistula utilizationAortocaval fistulaFistula patency