2023
EphB4 monomer inhibits chronic graft vasculopathy in an aortic transplant model
Langford J, Gonzalez L, Taniguchi R, Brahmandam A, Zhang W, Dardik A. EphB4 monomer inhibits chronic graft vasculopathy in an aortic transplant model. JVS Vascular Science 2023, 4: 100109. PMID: 37519335, PMCID: PMC10372308, DOI: 10.1016/j.jvssci.2023.100109.Peer-Reviewed Original ResearchAortic transplant modelAllograft vasculopathyT cellsTransplant modelEphrin-B2Immune cell accumulationChronic graftCardiac transplantChronic rejectionTransplanted graftAortic allograftsNeointima formationCell accumulationTissue damageMonocyte adhesionLess neointima formationVasculopathyAdherent monocytesEndothelial surfaceReceptor EphB4MacrophagesGraftMonocytesImportant targetCells
2022
Chapter 21 Normal vascular identity (arteries, veins, and lymphatics) and malformations
Gonzalez L, Dardik A. Chapter 21 Normal vascular identity (arteries, veins, and lymphatics) and malformations. 2022, 251-263. DOI: 10.1016/b978-0-12-822546-2.00016-2.ChaptersVascular identityArterial-venous identityEphrin-B2Corresponding biological functionsCritical molecular markersDelta-like 4Eph-B4Ephrin-B2 expressionEmbryonic developmentGrowth factor receptorBiological functionsMolecular markersArterial identityFunction mutationsVenous identityMolecular determinantsMolecular signaturesPhenotypic switchFactor receptorVascular endothelial growth factor receptorTranslational applicationsEndothelial growth factor receptorExpressionPathological conditionsMutations
2018
Molecular identity of arteries, veins, and lymphatics
Wolf K, Hu H, Isaji T, Dardik A. Molecular identity of arteries, veins, and lymphatics. Journal Of Vascular Surgery 2018, 69: 253-262. PMID: 30154011, PMCID: PMC6309638, DOI: 10.1016/j.jvs.2018.06.195.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsArteriesBiomarkersCOUP Transcription Factor IIEphrin-B2Gene Expression Regulation, DevelopmentalGestational AgeHomeodomain ProteinsHumansIntracellular Signaling Peptides and ProteinsLymphangiogenesisLymphatic VesselsMembrane ProteinsNeovascularization, PhysiologicReceptor, EphB4Receptors, NotchSignal TransductionTumor Suppressor ProteinsVascular Endothelial Growth Factor Receptor-2Vascular Surgical ProceduresVeinsConceptsMolecular identityEphrin-B2 expressionVessel identityVascular identityMolecular determinantsVenous identityArterial-venous identityCritical molecular determinantsEph-B4Specific molecular markersEmbryonic developmentMolecular mechanismsMolecular markersArterial identityUndifferentiated cellsEphrin-B2Adult vesselsDifferent functionsPostsurgical environmentExpressionEndothelial cellsStructural differencesCellsNew therapeutic approachesLymphatic vessels