2024
Differing Pattern of Mismatch Negativity Responses in Clinical and Nonclinical Voice Hearers Challenge Predictive Coding Accounts of Psychosis
Erickson M, Bansal S, Li C, Waltz J, Corlett P, Gold J. Differing Pattern of Mismatch Negativity Responses in Clinical and Nonclinical Voice Hearers Challenge Predictive Coding Accounts of Psychosis. Biological Psychiatry Global Open Science 2024, 5: 100394. PMID: 39526022, PMCID: PMC11550737, DOI: 10.1016/j.bpsgos.2024.100394.Peer-Reviewed Original ResearchHealthy comparison subjectsReduced mismatch negativityPrediction error signalsPositive symptomsMismatch negativityDeviant typesPredictive coding accountPresence of hallucinationsMismatch negativity paradigmAuditory memory tracesComparison subjectsCoding accountMemory tracesPsychiatric illnessMMN responseVoice hearersRepetitive positioningError signalDuration conditionsHallucinationsHigher-levelDMMNDifferent patternsSymptomsPSZ
2023
Using dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis
Fleming L, Lemonde A, Benrimoh D, Gold J, Taylor J, Malla A, Joober R, Iyer S, Lepage M, Shah J, Corlett P. Using dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis. Scientific Reports 2023, 13: 4841. PMID: 36964175, PMCID: PMC10039017, DOI: 10.1038/s41598-023-31909-w.Peer-Reviewed Original ResearchConceptsHallucinations/delusionsFirst-episode psychosisFirst-episode psychosis participantsEarly intervention programsPathophysiological mechanismsUnderlying pathophysiologyEpisode psychosisPsychotic illnessPsychotic symptomsPsychotic disordersSchizoaffective disorderAuditory hallucinationsPositive symptomsHallucination severityNegative symptomsSymptomsDisorganization symptomsIntervention programsHallucinationsIllnessPsychosis participantsPsychosisDelusionsDisordersParticipantsA pilot randomized controlled trial of ketamine in Borderline Personality Disorder
Fineberg S, Choi E, Shapiro-Thompson R, Dhaliwal K, Neustadter E, Sakheim M, Null K, Trujillo-Diaz D, Rondeau J, Pittaro G, Peters J, Corlett P, Krystal J. A pilot randomized controlled trial of ketamine in Borderline Personality Disorder. Neuropsychopharmacology 2023, 48: 991-999. PMID: 36804489, PMCID: PMC10209175, DOI: 10.1038/s41386-023-01540-4.Peer-Reviewed Original ResearchConceptsBorderline personality disorderSecondary outcome measuresOutcome measuresSocio-occupational functioningSuicidal ideationPilot studyTrial of ketaminePersonality disorderInfusion of ketaminePrimary outcome measureEffects of ketamineMidazolam groupAdverse eventsKetamine groupClinical benefitMood symptomsKetamineFDA approvalDrug midazolamInfusionBPD symptomsLarger studyDepressed moodSymptomsChronic mood
2012
The neurobiology of schizotypy: Fronto-striatal prediction error signal correlates with delusion-like beliefs in healthy people
Corlett PR, Fletcher PC. The neurobiology of schizotypy: Fronto-striatal prediction error signal correlates with delusion-like beliefs in healthy people. Neuropsychologia 2012, 50: 3612-3620. PMID: 23079501, PMCID: PMC3694307, DOI: 10.1016/j.neuropsychologia.2012.09.045.Peer-Reviewed Original ResearchConceptsHealthy peopleSymptoms of psychosisPsychotic illnessEarly psychosisHealthy individualsPsychosis showHealthy beliefsAdditional alterationsNeural markersNeural responsesSymptomsPsychosisNovel evidenceDelusional ideationDistressSchizotypal experiencesAlterationsPatientsPrevious observationsIllness
2009
From drugs to deprivation: a Bayesian framework for understanding models of psychosis
Corlett PR, Frith CD, Fletcher PC. From drugs to deprivation: a Bayesian framework for understanding models of psychosis. Psychopharmacology 2009, 206: 515-530. PMID: 19475401, PMCID: PMC2755113, DOI: 10.1007/s00213-009-1561-0.Peer-Reviewed Original ResearchConceptsSymptoms of psychosisImportance of perceptionsProcessing of informationCognitive modelPrior expectanciesPerceptual AberrationModel of psychosisNeural circuitryInformation processingDifferent manipulationsPositive symptomsExperimental manipulationSerotonergic hallucinogensPerceptionPsychosisNew predictionsPsychotomimetic drugsUseful settingProcessingDistinctive effectsSymptomsInferenceNMDA receptor antagonistDistinct symptomsLearning