2024
Understanding Cognitive Behavioral Therapy for Psychosis Through the Predictive Coding Framework
Sheffield J, Brinen A, Feola B, Heckers S, Corlett P. Understanding Cognitive Behavioral Therapy for Psychosis Through the Predictive Coding Framework. Biological Psychiatry Global Open Science 2024, 4: 100333. PMID: 38952435, PMCID: PMC11215207, DOI: 10.1016/j.bpsgos.2024.100333.Peer-Reviewed Original ResearchCognitive behavioral therapyPersecutory delusionsBehavioral therapyMaintenance of delusionsSymptoms of psychosisAssociative learning modelsCognitive-behavioral interventionsPrediction error signalsLevels of information processingPredictive coding frameworkHierarchical predictive codingPredictive codingPsychotic disordersPsychological treatmentCognitive neurosciencePsychological processesCBTpPsychosisDelusionsBelief updatingInformation processingAlternative beliefsNeuroscienceProcess theoryComputational neuroscience
2023
Using dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis
Fleming L, Lemonde A, Benrimoh D, Gold J, Taylor J, Malla A, Joober R, Iyer S, Lepage M, Shah J, Corlett P. Using dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis. Scientific Reports 2023, 13: 4841. PMID: 36964175, PMCID: PMC10039017, DOI: 10.1038/s41598-023-31909-w.Peer-Reviewed Original ResearchConceptsHallucinations/delusionsFirst-episode psychosisFirst-episode psychosis participantsEarly intervention programsPathophysiological mechanismsUnderlying pathophysiologyEpisode psychosisPsychotic illnessPsychotic symptomsPsychotic disordersSchizoaffective disorderAuditory hallucinationsPositive symptomsHallucination severityNegative symptomsSymptomsDisorganization symptomsIntervention programsHallucinationsIllnessPsychosis participantsPsychosisDelusionsDisordersParticipantsSelf-reported Gesture Interpretation and Performance Deficits in Individuals at Clinical High Risk for Psychosis
Karp E, Williams T, Ellman L, Strauss G, Walker E, Corlett P, Woods S, Powers A, Gold J, Schiffman J, Waltz J, Silverstein S, Mittal V. Self-reported Gesture Interpretation and Performance Deficits in Individuals at Clinical High Risk for Psychosis. Schizophrenia Bulletin 2023, 49: 746-755. PMID: 36939086, PMCID: PMC10154698, DOI: 10.1093/schbul/sbac197.Peer-Reviewed Original ResearchConceptsClinical high riskGesture deficitsInternalizing disordersCHR groupGesture interpretationLower verbal learningViable assessment toolVerbal learningNeurocognitive tasksGeneral intelligencePerformance deficitsNonverbal behaviorProcessing speedCHR participantsSimilar deficitsGreater deficitsHigh riskClinical InterviewFull psychotic disorderDeficitsSpecific subdomainsSRGPPsychotic disordersPsychosisGesturesThe reliability and validity of the revised Green et al. paranoid thoughts scale in individuals at clinical high‐risk for psychosis
Williams T, Walker E, Strauss G, Woods S, Powers A, Corlett P, Schiffman J, Waltz J, Gold J, Silverstein S, Ellman L, Zinbarg R, Mittal V. The reliability and validity of the revised Green et al. paranoid thoughts scale in individuals at clinical high‐risk for psychosis. Acta Psychiatrica Scandinavica 2023, 147: 623-633. PMID: 36905387, PMCID: PMC10463775, DOI: 10.1111/acps.13545.Peer-Reviewed Original ResearchConceptsCHR individualsClinical controlFull psychosisHealthy controlsGeneral populationPsychosis symptomsCHR participantsPoor social functioningGreen Paranoid Thoughts ScalePsychosisGroup differencesSocial functioningConfirmatory factor analysisParanoid Thoughts ScaleInterview measuresSeverity continuumTwo-factor structureCritical populationSelf-report measuresPresent studyDiscriminant validityPsychometric indicesParanoid thoughtsIndividualsParticipantsComparing a Computerized Digit Symbol Test to a Pen-and-Paper Classic
Pratt D, Luther L, Kinney K, Osborne K, Corlett P, Powers A, Woods S, Gold J, Schiffman J, Ellman L, Strauss G, Walker E, Zinbarg R, Waltz J, Silverstein S, Mittal V. Comparing a Computerized Digit Symbol Test to a Pen-and-Paper Classic. Schizophrenia Bulletin Open 2023, 4: sgad027. PMID: 37868160, PMCID: PMC10590153, DOI: 10.1093/schizbullopen/sgad027.Peer-Reviewed Original ResearchClinical high riskCHR individualsFinger-tapping taskMotor ability measuresDigit symbol testCHR stateHealthy controlsHigh riskClinical InterviewPersistent subgroupSymbol testPersistent groupImpairmentPaper versionMotor abilitiesTask performance differencesComputerized versionSimilar degreeEffect sizeMeasures impairmentPsychosisCoding TestRemote assessmentSubgroupsDigit-symbol task
2013
Chapter 13 The Translational Potential of Memory Reconsolidation
Corlett P, Taylor J. Chapter 13 The Translational Potential of Memory Reconsolidation. 2013, 273-292. DOI: 10.1016/b978-0-12-386892-3.00013-5.Peer-Reviewed Original ResearchPost-traumatic stress disorderMemory labileMemory reconsolidationMemory processingLabile stateStress disorderMemory erasureDrug addictionPast experienceReconsolidationSerious mental illnessCurrent processingMemoryMental illnessProcessingAddictionEthical implicationsChapter 13PsychosisDisordersImplicationsIllnessExperience
2012
The neurobiology of schizotypy: Fronto-striatal prediction error signal correlates with delusion-like beliefs in healthy people
Corlett PR, Fletcher PC. The neurobiology of schizotypy: Fronto-striatal prediction error signal correlates with delusion-like beliefs in healthy people. Neuropsychologia 2012, 50: 3612-3620. PMID: 23079501, PMCID: PMC3694307, DOI: 10.1016/j.neuropsychologia.2012.09.045.Peer-Reviewed Original ResearchConceptsHealthy peopleSymptoms of psychosisPsychotic illnessEarly psychosisHealthy individualsPsychosis showHealthy beliefsAdditional alterationsNeural markersNeural responsesSymptomsPsychosisNovel evidenceDelusional ideationDistressSchizotypal experiencesAlterationsPatientsPrevious observationsIllness
2009
From drugs to deprivation: a Bayesian framework for understanding models of psychosis
Corlett PR, Frith CD, Fletcher PC. From drugs to deprivation: a Bayesian framework for understanding models of psychosis. Psychopharmacology 2009, 206: 515-530. PMID: 19475401, PMCID: PMC2755113, DOI: 10.1007/s00213-009-1561-0.Peer-Reviewed Original ResearchConceptsSymptoms of psychosisImportance of perceptionsProcessing of informationCognitive modelPrior expectanciesPerceptual AberrationModel of psychosisNeural circuitryInformation processingDifferent manipulationsPositive symptomsExperimental manipulationSerotonergic hallucinogensPerceptionPsychosisNew predictionsPsychotomimetic drugsUseful settingProcessingDistinctive effectsSymptomsInferenceNMDA receptor antagonistDistinct symptomsLearning
2007
Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions
Corlett PR, Murray GK, Honey GD, Aitken MR, Shanks DR, Robbins TW, Bullmore ET, Dickinson A, Fletcher PC. Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions. Brain 2007, 130: 2387-2400. PMID: 17690132, PMCID: PMC3838942, DOI: 10.1093/brain/awm173.Peer-Reviewed Original ResearchConceptsDelusion formationDelusional beliefsPrediction error processingPrediction-error signallingPrediction error signalsAttentional allocationAssociative accountMaladaptive beliefsError processingAssociative learningNeurobiological theoriesBrain responsesCortex responsesIndividual's propensityBelief formationDelusionsBeliefsPrediction errorExtent of disruptionProcessingFMRILearningPsychosisExpectancyIndividualsFrom prediction error to psychosis: ketamine as a pharmacological model of delusions
Corlett PR, Honey GD, Fletcher PC. From prediction error to psychosis: ketamine as a pharmacological model of delusions. Journal Of Psychopharmacology 2007, 21: 238-252. PMID: 17591652, DOI: 10.1177/0269881107077716.Peer-Reviewed Original ResearchConceptsDelusion formationAssociative learning processesPrediction error signalsDevelopment of delusionsFormation of delusionsPre-psychotic periodAttentional disruptionAttentional disturbancesNeuropsychiatric modelsNeurobiological systemsPrediction errorExperience resultsLearning processIrrelevant detailsDelusionsError signalDrug ketaminePsychosisNumerous associationsPsychotic statesPerceptExpectationsPharmacological modelStimuliSymptom evolution