Publications

• Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma.Gautam S, Chu JH, Cohen AJ, Kaur R, Lee S, Wilson G, Liu Q, Gomez J, Rajaveen H, Yan X, Cohn L, Clark BJ, Chupp GL. Allergy. 2023 Dec; 2023 Oct 24. PMID: 37874609.
• Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19.Liu Y, Rajeevan H, Simonov M, Lee S, Wilson FP, Desir GV, Vinetz JM, Yan X, Wang Z, Clark BJ, Possick JD, Price C, Lutchmansingh DD, Ortega H, Zaeh S, Gomez JV, Cohn L, Gautam S, Chupp GL. J Allergy Clin Immunol Pract. 2023 Nov; 2023 Jul 14. PMID: 37454926.
• The long-term effect of dupilumab on dyspnea, sleep, and activity in oral corticosteroid-dependent severe asthma.Sher LD, Passalacqua G, Taillé C, Cohn L, Daizadeh N, Pandit-Abid N, Soler X, Khodzhayev A, Jacob-Nara JA, Deniz Y, Rowe PJ, Nag A, Zhang Y. Ann Allergy Asthma Immunol. 2023 Mar; 2022 Dec 9. PMID: 36509407.
• Patient Preferences for Attributes of Biologic Treatments in Moderate to Severe Asthma: A Discrete Choice Experiment Study.Yang M, Chao J, Fillbrunn M, Mallya UG, Wang MJ, Franke L, Cohn L, Kamat S. Patient Prefer Adherence. 2022; 2022 Sep 23. PMID: 36176349.
• Can asthma biologics change the course of disease and induce drug-free remission?Cohn L. J Allergy Clin Immunol. 2022 Jul; 2022 Apr 18. PMID: 35447228.
• SPLUNC1: a novel marker of cystic fibrosis exacerbations.Khanal S, Webster M, Niu N, Zielonka J, Nunez M, Chupp G, Slade MD, Cohn L, Sauler M, Gomez JL, Tarran R, Sharma L, Dela Cruz CS, Egan M, Laguna T, Britto CJ. Eur Respir J. 2021 Nov; 2021 Nov 11. PMID: 33958427.
• A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY: Learning From the Past, Looking to the Future.Lutchmansingh DD, Knauert MP, Antin-Ozerkis DE, Chupp G, Cohn L, Dela Cruz CS, Ferrante LE, Herzog EL, Koff J, Rochester CL, Ryu C, Singh I, Tickoo M, Winks V, Gulati M, Possick JD. Chest. 2021 Mar; 2020 Nov 4. PMID: 33159907.
• A Network of Sputum MicroRNAs Is Associated with Neutrophilic Airway Inflammation in Asthma.Gomez JL, Chen A, Diaz MP, Zirn N, Gupta A, Britto C, Sauler M, Yan X, Stewart E, Santerian K, Grant N, Liu Q, Fry R, Rager J, Cohn L, Alexis N, Chupp GL. Am J Respir Crit Care Med. 2020 Jul 1. PMID: 32255668.
• An endothelial microRNA-1-regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitis.Korde A, Ahangari F, Haslip M, Zhang X, Liu Q, Cohn L, Gomez JL, Chupp G, Pober JS, Gonzalez A, Takyar SS. J Allergy Clin Immunol. 2020 Feb. PMID: 32035607.
• BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation.Britto CJ, Niu N, Khanal S, Huleihel L, Herazo-Maya JD, Thompson A, Sauler M, Slade MD, Sharma L, Dela Cruz CS, Kaminski N, Cohn LE. Am J Physiol Lung Cell Mol Physiol. 2019 Feb 1; 2018 Nov 21. PMID: 30461288.
• Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair.Jin H, Ciechanowicz AK, Kaplan AR, Wang L, Zhang PX, Lu YC, Tobin RE, Tobin BA, Cohn L, Zeiss CJ, Lee PJ, Bruscia EM, Krause DS. Am J Physiol Lung Cell Mol Physiol. 2018 May 1; 2018 Jan 18. PMID: 29345196.
• Characterisation of asthma subgroups associated with circulating YKL-40 levels.Gomez JL, Yan X, Holm CT, Grant N, Liu Q, Cohn L, Nezgovorova V, Meyers DA, Bleecker ER, Crisafi GM, Jarjour NN, Rogers L, Reibman J, Chupp GL. Eur Respir J. 2017 Oct; 2017 Oct 12. PMID: 29025889.
• Long-term outcomes of bronchial thermoplasty in subjects with severe asthma: a comparison of 3-year follow-up results from two prospective multicentre studies.Chupp G, Laviolette M, Cohn L, McEvoy C, Bansal S, Shifren A, Khatri S, Grubb GM, McMullen E, Strauven R, Kline JN. Eur Respir J. 2017 Aug; 2017 Aug 31. PMID: 28860266.
• A novel pathway-based distance score enhances assessment of disease heterogeneity in gene expression.Yan X, Liang A, Gomez J, Cohn L, Zhao H, Chupp GL. BMC Bioinformatics. 2017 Jun 20; 2017 Jun 20. PMID: 28637421.
• Sputum Gene Expression of IL-13 Receptor α2 Chain Correlates with Airflow Obstruction and Helper T-Cell Type 2 Inflammation in Asthma.Nezgovorova V, Liu Q, Hu B, Villalobos JL, Yan X, Niu N, Holm C, Grant NP, Marone S, Ravage-Mass L, Lee CG, Elias JA, Cohn L, Chupp GL. Ann Am Thorac Soc. 2016 Mar. PMID: 27027964.
• Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma.Yan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL. Ann Am Thorac Soc. 2016 Mar. PMID: 27027945.
• Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40.Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N, Cohn L, Chupp GL. J Allergy Clin Immunol. 2015 Jul; 2015 Jan 13. PMID: 25592985.
• Bactericidal/Permeability-increasing protein fold-containing family member A1 in airway host protection and respiratory disease.Britto CJ, Cohn L. Am J Respir Cell Mol Biol. 2015 May. PMID: 25265466.
• Update in asthma 2013.Cohn L, Woodruff PG. Am J Respir Crit Care Med. 2014 Jun 15. PMID: 24930529.
• VEGF controls lung Th2 inflammation via the miR-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin axis.Takyar S, Vasavada H, Zhang JG, Ahangari F, Niu N, Liu Q, Lee CG, Cohn L, Elias JA. J Exp Med. 2013 Sep 23; 2013 Sep 16. PMID: 24043765.
• Short palate, lung, and nasal epithelial clone-1 is a tightly regulated airway sensor in innate and adaptive immunity.Britto CJ, Liu Q, Curran DR, Patham B, Dela Cruz CS, Cohn L. Am J Respir Cell Mol Biol. 2013 Jun. PMID: 23470624.
• Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells.Chatterjee B, Smed-Sörensen A, Cohn L, Chalouni C, Vandlen R, Lee BC, Widger J, Keler T, Delamarre L, Mellman I. Blood. 2012 Sep 6; 2012 Jul 12. PMID: 22791285.
• IFN-γ acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease.Mitchell C, Provost K, Niu N, Homer R, Cohn L. J Immunol. 2011 Oct 1; 2011 Aug 26. PMID: 21873527.
• Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation.Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC. J Exp Med. 2010 Nov 22; 2010 Oct 25. PMID: 20975041.
• Advances in mucous cell metaplasia: a plug for mucus as a therapeutic focus in chronic airway disease.Curran DR, Cohn L. Am J Respir Cell Mol Biol. 2010 Mar; 2009 Jun 11. PMID: 19520914.
• Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.Wang Z, Kumamoto Y, Wang P, Gan X, Lehmann D, Smrcka AV, Cohn L, Iwasaki A, Li L, Wu D. J Biol Chem. 2009 Oct 16; 2009 Aug 27. PMID: 19713215.
• Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation.Chapoval SP, Lee CG, Tang C, Keegan AD, Cohn L, Bottomly K, Elias JA. Clin Immunol. 2009 Sep; 2009 Jun 24. PMID: 19553159.
• Cutting edge: Limiting MHC class II expression to dendritic cells alters the ability to develop Th2- dependent allergic airway inflammation.Niu N, Laufer T, Homer RJ, Cohn L. J Immunol. 2009 Aug 1; 2009 Jul 13. PMID: 19596982.
• A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma.Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. Proc Natl Acad Sci U S A. 2009 Jun 2; 2009 May 19. PMID: 19458046.
• Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.Lee CG, Hartl D, Lee GR, Koller B, Matsuura H, Da Silva CA, Sohn MH, Cohn L, Homer RJ, Kozhich AA, Humbles A, Kearley J, Coyle A, Chupp G, Reed J, Flavell RA, Elias JA. J Exp Med. 2009 May 11; 2009 May 4. PMID: 19414556.
• TRPA1 is a major oxidant sensor in murine airway sensory neurons.Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, Jordt SE. J Clin Invest. 2008 May. PMID: 18398506.
• A novel pathway that regulates inflammatory disease in the respiratory tract.Niu N, Le Goff MK, Li F, Rahman M, Homer RJ, Cohn L. J Immunol. 2007 Mar 15. PMID: 17339484.
• Toll-like receptor 4 deficiency causes pulmonary emphysema.Zhang X, Shan P, Jiang G, Cohn L, Lee PJ. J Clin Invest. 2006 Nov; 2006 Oct 19. PMID: 17053835.
• Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation.Homer RJ, Zhu Z, Cohn L, Lee CG, White WI, Chen S, Elias JA. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 2006 Mar 23. PMID: 16556727.
• Mucus in chronic airway diseases: sorting out the sticky details.Cohn L. J Clin Invest. 2006 Feb. PMID: 16453018.
• Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung.Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM, Elias JA. Nat Med. 2004 Oct; 2004 Sep 19. PMID: 15378055.
• Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation.Zhu Z, Zheng T, Homer RJ, Kim YK, Chen NY, Cohn L, Hamid Q, Elias JA. Science. 2004 Jun 11. PMID: 15192232.
• Asthma: mechanisms of disease persistence and progression.Cohn L, Elias JA, Chupp GL. Annu Rev Immunol. 2004. PMID: 15032597.
• Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9.Whittaker L, Niu N, Temann UA, Stoddard A, Flavell RA, Ray A, Homer RJ, Cohn L. Am J Respir Cell Mol Biol. 2002 Nov. PMID: 12397019.
• Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways.Lee CG, Homer RJ, Cohn L, Link H, Jung S, Craft JE, Graham BS, Johnson TR, Elias JA. J Biol Chem. 2002 Sep 20; 2002 Jul 9. PMID: 12107190.
• Resolution of lung inflammation by CD44.Teder P, Vandivier RW, Jiang D, Liang J, Cohn L, Puré E, Henson PM, Noble PW. Science. 2002 Apr 5. PMID: 11935029.
• Cytokine regulation of mucus production in a model of allergic asthma.Cohn L, Whittaker L, Niu N, Homer RJ. Novartis Found Symp. 2002. PMID: 12568496.
• Food for thought: can immunological tolerance be induced to treat asthma?Cohn L. Am J Respir Cell Mol Biol. 2001 May. PMID: 11350818.
• IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation.Cohn L, Herrick C, Niu N, Homer R, Bottomly K. J Immunol. 2001 Feb 15. PMID: 11160342.
• A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation.Das J, Chen CH, Yang L, Cohn L, Ray P, Ray A. Nat Immunol. 2001 Jan. PMID: 11135577.
• Altering the Th1/Th2 balance as a therapeutic strategy in asthmatic diseases.Ray A, Cohn L. Curr Opin Investig Drugs. 2000 Dec. PMID: 11249697.
• T-helper type 2 cell-directed therapy for asthma.Cohn L, Ray A. Pharmacol Ther. 2000 Nov. PMID: 11150597.
• IL-11 selectively inhibits aeroallergen-induced pulmonary eosinophilia and Th2 cytokine production.Wang J, Homer RJ, Hong L, Cohn L, Lee CG, Jung S, Elias JA. J Immunol. 2000 Aug 15. PMID: 10925310.
• T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production.Cohn L, Homer RJ, Niu N, Bottomly K. J Exp Med. 1999 Nov 1. PMID: 10544202.
• Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3.Zhang DH, Yang L, Cohn L, Parkyn L, Homer R, Ray P, Ray A. Immunity. 1999 Oct. PMID: 10549629.
• Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation.Ray A, Cohn L. J Clin Invest. 1999 Oct. PMID: 10525032.
• Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils.Cohn L, Homer RJ, MacLeod H, Mohrs M, Brombacher F, Bottomly K. J Immunol. 1999 May 15. PMID: 10229862.
• Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation.Yang L, Cohn L, Zhang DH, Homer R, Ray A, Ray P. J Exp Med. 1998 Nov 2. PMID: 9802985.
• IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells.Cohn L, Tepper JS, Bottomly K. J Immunol. 1998 Oct 15. PMID: 9780144.
• Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production.Cohn L, Homer RJ, Marinov A, Rankin J, Bottomly K. J Exp Med. 1997 Nov 17. PMID: 9362533.
• Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene.Zhang DH, Cohn L, Ray P, Bottomly K, Ray A. J Biol Chem. 1997 Aug 22. PMID: 9261181.