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Caroline Johnson and Nick Rattray setting up the mass spectrometer.

The Johnson Laboratory aims to develop a deeper understanding of the metabolic response to environmental exposures. To do this, we have developed a combination of discovery and hypothesis-driven mass spectrometry-based metabolomic approaches to identify a broad range of metabolites. Using computational tools and orthogonal biological techniques, we investigate and manipulate metabolic pathways to gain insight into the underlying physiological response.

Current projects in the Johnson lab include:

  • The relationship between genetic predisposition and environmental influences in left- versus right-sided colon cancer.
  • Assessment of chemical exposures and adverse pregnancy outcomes.