Michal Kidacki, MD, PhD
InstructorCards
About
Research
Overview
Medical Research Interests
Hair Follicle; Immune System
Publications
2024
207 Spatial transcriptomic profiling non-small cell lung cancer reveals potential drivers of CTL exclusion and dysfunction, and identifies novel predictive biomarkers for checkpoint blockade therapy
Cho C, Lopez-Giraldez F, Huang B, He J, Woodard G, Badri T, Kidacki M, Vesely M, Wang G, Ofori-Ntiamoah G, Ng E, Chen L. 207 Spatial transcriptomic profiling non-small cell lung cancer reveals potential drivers of CTL exclusion and dysfunction, and identifies novel predictive biomarkers for checkpoint blockade therapy. 2024, a236-a236. DOI: 10.1136/jitc-2024-sitc2024.0207.Peer-Reviewed Original ResearchSpatial Transcriptomics in Inflammatory Skin Diseases Using GeoMx Digital Spatial Profiling: A Practical Guide for Applications in Dermatology
Cho C, Haddadi N, Kidacki M, Woodard G, Shakiba S, Yıldız-Altay Ü, Richmond J, Vesely M. Spatial Transcriptomics in Inflammatory Skin Diseases Using GeoMx Digital Spatial Profiling: A Practical Guide for Applications in Dermatology. JID Innovations 2024, 5: 100317. PMID: 39559817, PMCID: PMC11570843, DOI: 10.1016/j.xjidi.2024.100317.Peer-Reviewed Original ResearchDigital spatial profilingInflammatory skin diseaseGeoMx Digital Spatial ProfilerSkin diseasesDiscoid lupus erythematosusNanoString GeoMx Digital Spatial ProfilingImmune milieuImmune microenvironmentLichen planusLupus erythematosusSingle cell RNA sequencingAberrant inflammationCell RNA sequencingSkin disease pathogenesisDisease pathogenesisManufacturer's guidelinesIndicators of diseaseDiseaseSpatial transcriptomics platformSkinTissue processing
2023
Immune Inhibitory Molecule PD-1 Homolog (VISTA) Colocalizes with CD11b Myeloid Cells in Melanoma and Is Associated with Poor Outcomes
Vesely M, Kidacki M, Gaule P, Gupta S, Chan N, Han X, Yeung J, Chen L. Immune Inhibitory Molecule PD-1 Homolog (VISTA) Colocalizes with CD11b Myeloid Cells in Melanoma and Is Associated with Poor Outcomes. Journal Of Investigative Dermatology 2023, 144: 106-115.e4. PMID: 37562584, DOI: 10.1016/j.jid.2023.07.008.Peer-Reviewed Original ResearchConceptsCD11b myeloid cellsImmune inhibitory moleculesPD-L1 expressionVISTA expressionMyeloid cellsFuture potential therapeutic targetsPD-L1/B7Tumor microenvironmentInhibitory moleculesMultiplexed quantitative immunofluorescencePrimary cutaneous melanomaImmunosuppressive tumor microenvironmentNegative prognostic biomarkerCurrent clinical trialsPotential therapeutic targetCause mortalityCritical cell typesPD-L1Poor outcomeTreatment of cancerMelanoma recurrenceCutaneous melanomaClinical trialsPrognostic biomarkerT cells
2021
Iatrogenic calcinosis cutis from extravasated phosphate-containing solution treated with topical sodium thiosulfate
Xie CB, Kidacki M, Ring N, Panse G, Leventhal JS. Iatrogenic calcinosis cutis from extravasated phosphate-containing solution treated with topical sodium thiosulfate. JAAD Case Reports 2021, 17: 31-33. PMID: 34692964, PMCID: PMC8517711, DOI: 10.1016/j.jdcr.2021.09.013.Peer-Reviewed Case Reports and Technical Notes
2020
Twist2 is NFkB-responsive when p120-catenin is inactivated and EGFR is overexpressed in esophageal keratinocytes
Lehman H, Kidacki M, Stairs D. Twist2 is NFkB-responsive when p120-catenin is inactivated and EGFR is overexpressed in esophageal keratinocytes. Scientific Reports 2020, 10: 18829. PMID: 33139779, PMCID: PMC7608670, DOI: 10.1038/s41598-020-75866-0.Peer-Reviewed Original ResearchConceptsEsophageal squamous cell carcinomaCancer typesYear of diagnosisSquamous cell carcinomaEsophageal keratinocytesOverexpression of EGFRHuman esophageal keratinocytesAggressive cell typesFatal cancer typePoor prognosisCell carcinomaTwist2 expressionEGFR overexpressionEGFREMT-inducing geneNFkBResponsive targetsTwist2Paucity of researchCell typesPresent studyKeratinocytesP120-cateninOverexpressionComplete loss
2019
E‐cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions
Nelson AM, Cong Z, Gettle SL, Longenecker AL, Kidacki M, Kirby JS, Adams DR, Stairs DB, Danby FW. E‐cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions. Experimental Dermatology 2019, 28: 867-871. PMID: 31107992, DOI: 10.1111/exd.13973.Peer-Reviewed Original ResearchConceptsProtein expressionHS lesional skinPathogenesis of HSInflammatory skin diseaseJunction proteinsHidradenitis suppurativa lesionsInflammatory skin conditionNon-lesional skinSevere skin lesionsE-cadherinAdherens junction proteinsE-cadherin expressionHurley stageAtopic dermatitisLesional skinDesmosome sizeHS pathogenesisHS skinAcne vulgarisHS patientsSkin lesionsPilosebaceous unitSkin conditionsSkin diseasesHealthy skin1028 Deciphering the mechanism of action of isotretinoin in acne patients using next gene sequencing technologies
Thiboutot D, Kidacki M, Sarfo A, Schneider A, Albert I, Longenecker A, Cong Z, Nelson A. 1028 Deciphering the mechanism of action of isotretinoin in acne patients using next gene sequencing technologies. Journal Of Investigative Dermatology 2019, 139: s178. DOI: 10.1016/j.jid.2019.03.1104.Peer-Reviewed Original Research‘Invasive proliferative gelatinous mass’ of hidradenitis suppurativa contains distinct inflammatory components
Kidacki M, Cong Z, Flamm A, Helm K, Danby FW, Nelson AM. ‘Invasive proliferative gelatinous mass’ of hidradenitis suppurativa contains distinct inflammatory components. British Journal Of Dermatology 2019, 181: 192-193. PMID: 30597519, DOI: 10.1111/bjd.17541.Peer-Reviewed Original ResearchAn Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis.
Albano-Aluquin S, Malysz J, Kidacki M, Ratnam M, Olsen NJ. An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis. Journal Of Visualized Experiments 2019 PMID: 30799840, DOI: 10.3791/58713.Peer-Reviewed Original ResearchConceptsGiant cell arteritisFolate receptor betaCell arteritisImmune microenvironmentChronic immune-mediated diseaseImmune-mediated diseasesTemporal artery biopsyT helper lymphocytesLarge-sized arteriesPro-inflammatory responseMyeloid leukemia cellsOcclusive symptomsTotal CD68Disease activityInflammatory disease researchArtery biopsyLymphohistiocytic inflammationSynovial macrophagesSized arteriesCD3 expressionTherapeutic responseVision lossImmunohistopathologic studyPathognomonic featuresIntimal hyperplasiaAn Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Albano-Aluquin S, Malysz J, Kidacki M, Ratnam M, Olsen N. An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis. Journal Of Visualized Experiments 2019 DOI: 10.3791/58713-v.Peer-Reviewed Case Reports and Technical Notes