2024
Decoding transcriptomic signatures of cysteine string protein alpha–mediated synapse maintenance
Wang N, Zhu B, Allnutt M, Grijalva R, Zhao H, Chandra S. Decoding transcriptomic signatures of cysteine string protein alpha–mediated synapse maintenance. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2320064121. PMID: 38833477, PMCID: PMC11181078, DOI: 10.1073/pnas.2320064121.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHSP40 Heat-Shock ProteinsMembrane ProteinsMiceMice, KnockoutNeurogliaNeuronsSynapsesTranscriptomeConceptsSynapse maintenanceTranscriptional changesSynaptogenic adhesion moleculesGene ontology analysisKO miceKO brainMaintenance in vivoCell-cell interactionsGlial cellsSingle-nucleus transcriptomesOntology analysisCspADifferential expressionNeuron-glia interactionsAutophagy-related genesProtein AGenesCell typesNeurodegenerative diseasesInhibitory synapsesLittermate controlsSynaptic pathwaysAdhesion moleculesGlial responseSynapse
2020
Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination
Zhou L, Shao C, Xie Y, Wang N, Xu S, Luo B, Wu Z, Ke Y, Qiu M, Shen Y. Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination. ELife 2020, 9: e52056. PMID: 31944179, PMCID: PMC6984811, DOI: 10.7554/elife.52056.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCateninsCell DifferentiationCell LineageCentral Nervous SystemGene Expression RegulationMiceMice, KnockoutOligodendrocyte Precursor CellsOligodendrogliaPlatelet-Derived Growth FactorProtein-Tyrosine KinasesReceptors, Growth FactorRNA, Small InterferingSignal TransductionTranscription FactorsTranscriptomeConceptsPlatelet-derived growth factorCentral nervous system myelinDownstream targetsPlatelet-derived growth factor stimulationPDGF signalingPlatelet-derived growth factor signalingReceptor tyrosine kinasesAdaptor proteinCentral nervous system hypomyelinationGab1Nuclear accumulationOligodendrocyte precursor cellsTyrosine kinaseCentral nervous systemOligodendrocyte precursor cell differentiationConditional deletionOL lineage cellsOligodendrocyte differentiationDifferentiationSteady-state numberB-cateninPrecursor cellsLineage cellsTrophic supportGrowth factor
2019
Numb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors
Wang N, Wang D, Shen Y. Numb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors. Neuroscience Letters 2019, 707: 134291. PMID: 31129078, DOI: 10.1016/j.neulet.2019.134291.Peer-Reviewed Original ResearchConceptsMembrane expressionExpression of metabotropic glutamate receptor 1Expression of metabotropic glutamate receptor 5Metabotropic glutamate receptor 1Expression of mGlu5Metabotropic glutamate receptor 5Clathrin-coated vesiclesGlutamate receptor 1Functions of NumbGlutamate receptor 5Three-chamber social testNumb deficiencyAutistic-like behaviorsTrans-membrane receptorsHomologous genesExcitatory neuronsReceptor 5MGlu5Receptor 1Impaired traffickingConditional knockoutNumbnessBrain regionsSocial testMotor coordination
2012
AMPA Receptors Regulate Exocytosis and Insulin Release in Pancreatic β Cells
Wu Z, Zhu L, Zou N, Bombek L, Shao C, Wang N, Wang X, Liang L, Xia J, Rupnik M, Shen Y. AMPA Receptors Regulate Exocytosis and Insulin Release in Pancreatic β Cells. Traffic 2012, 13: 1124-1139. PMID: 22540213, DOI: 10.1111/j.1600-0854.2012.01373.x.Peer-Reviewed Original ResearchConceptsK(ATP) channelsGlutamate applicationB cellsInsulin releaseA-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptorIonotropic glutamate receptorsKnock-out miceDepolarization-induced exocytosisMouse B cellsInsulin-containing granulesPancreatic B-cellsGlutamate receptorsCytosolic calciumCytosolic cGMPAMPARAcid receptorsInsulin secretionInsulinoma cellsInsulinGlutamateMiceReceptorsExocytosisIGluRsRelease