Publications

• Setdb1-loss induces type-I interferons and immune clearance of melanoma.McGeary MK, Damsky W, Daniels AJ, Lang SM, Xu Q, Song E, Huet-Calderwood C, Lou HJ, Paradkar S, Micevic G, Kaech SM, Calderwood DA, Turk BE, Yan Q, Iwasaki A, Bosenberg MW. Cancer Immunol Res. 2024 Nov 26; 2024 Nov 26. PMID: 39589394.
• The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8(+) T cells.Liao X, Li W, Zhou H, Rajendran BK, Li A, Ren J, Luan Y, Calderwood DA, Turk B, Tang W, Liu Y, Wu D. Nat Commun. 2024 Jan 19; 2024 Jan 19. PMID: 38242867.
• Intracellular tension sensor reveals mechanical anisotropy of the actin cytoskeleton.Amiri S, Muresan C, Shang X, Huet-Calderwood C, Schwartz MA, Calderwood DA, Murrell M. Nat Commun. 2023 Dec 4; 2023 Dec 4. PMID: 38049429.
• Author Correction: Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4).Ha BH, Yigit S, Natarajan N, Morse EM, Calderwood DA, Boggon TJ. Commun Biol. 2023 Jul 31; 2023 Jul 31. PMID: 37524913.
• Setdb1 -loss induces type-I interferons and immune clearance of melanoma.McGeary MK, Damsky W, Daniels A, Song E, Micevic G, Huet-Calderwood C, Lou HJ, Paradkar S, Kaech S, Calderwood DA, Turk BE, Iwasaki A, Bosenberg MW. bioRxiv. 2023 May 24; 2023 May 24. PMID: 37292991.
• Fibroblasts secrete fibronectin under lamellipodia in a microtubule- and myosin II-dependent fashion.Huet-Calderwood C, Rivera-Molina FE, Toomre DK, Calderwood DA. J Cell Biol. 2023 Feb 6; 2022 Nov 23. PMID: 36416725.
• Organization, dynamics and mechanoregulation of integrin-mediated cell-ECM adhesions.Kanchanawong P, Calderwood DA. Nat Rev Mol Cell Biol. 2023 Feb; 2022 Sep 27. PMID: 36168065.
• Use of Ecto-Tagged Integrins to Monitor Integrin Exocytosis and Endocytosis.Huet-Calderwood C, Rivera-Molina F, Toomre D, Calderwood DA. Methods Mol Biol. 2023. PMID: 36653699.
• Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4).Ha BH, Yigit S, Natarajan N, Morse EM, Calderwood DA, Boggon TJ. Commun Biol. 2022 Nov 17; 2022 Nov 17. PMID: 36385162.
• Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.Simon B, Lou HJ, Huet-Calderwood C, Shi G, Boggon TJ, Turk BE, Calderwood DA. Nat Commun. 2022 Feb 8; 2022 Feb 8. PMID: 35136069.
• A Small-Scale shRNA Screen in Primary Mouse Macrophages Identifies a Role for the Rab GTPase Rab1b in Controlling Salmonella Typhi Growth.Solano-Collado V, Colamarino RA, Calderwood DA, Baldassarre M, Spanò S. Front Cell Infect Microbiol. 2021; 2021 Apr 7. PMID: 33898333.
• PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK.Cho E, Lou HJ, Kuruvilla L, Calderwood DA, Turk BE. Cell Rep. 2021 Mar 30. PMID: 33789117.
• Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association.Zhou M, Kuruvilla L, Shi X, Viviano S, Ahearn IM, Amendola CR, Su W, Badri S, Mahaffey J, Fehrenbacher N, Skok J, Schlessinger J, Turk BE, Calderwood DA, Philips MR. Proc Natl Acad Sci U S A. 2020 Dec 15; 2020 Nov 30. PMID: 33257571.
• Signalling through cerebral cavernous malformation protein networks.Su VL, Calderwood DA. Open Biol. 2020 Nov; 2020 Nov 25. PMID: 33234067.
• Differences in self-association between kindlin-2 and kindlin-3 are associated with differential integrin binding.Kadry YA, Maisuria EM, Huet-Calderwood C, Calderwood DA. J Biol Chem. 2020 Aug 7; 2020 Jun 16. PMID: 32546480.
• Chapter 22: Structural and signaling functions of integrins.Kadry YA, Calderwood DA. Biochim Biophys Acta Biomembr. 2020 May 1; 2020 Jan 25. PMID: 31991120.
• Serine phosphorylation of the small phosphoprotein ICAP1 inhibits its nuclear accumulation.Su VL, Simon B, Draheim KM, Calderwood DA. J Biol Chem. 2020 Mar 6; 2020 Jan 31. PMID: 32005669.
• The subcellular localization of type I p21-activated kinases is controlled by the disordered variable region and polybasic sequences.Sun X, Su VL, Calderwood DA. J Biol Chem. 2019 Sep 27; 2019 Aug 7. PMID: 31391252.
• Filamin A mediates isotropic distribution of applied force across the actin network.Kumar A, Shutova MS, Tanaka K, Iwamoto DV, Calderwood DA, Svitkina TM, Schwartz MA. J Cell Biol. 2019 Aug 5; 2019 Jul 17. PMID: 31315944.
• Coarse-Grained Simulation of Full-Length Integrin Activation.Bidone TC, Polley A, Jin J, Driscoll T, Iwamoto DV, Calderwood DA, Schwartz MA, Voth GA. Biophys J. 2019 Mar 19; 2019 Feb 22. PMID: 30851876.
• Kindlin-2 interacts with a highly conserved surface of ILK to regulate focal adhesion localization and cell spreading.Kadry YA, Huet-Calderwood C, Simon B, Calderwood DA. J Cell Sci. 2018 Oct 26; 2018 Oct 26. PMID: 30254023.
• Structural basis of the filamin A actin-binding domain interaction with F-actin.Iwamoto DV, Huehn A, Simon B, Huet-Calderwood C, Baldassarre M, Sindelar CV, Calderwood DA. Nat Struct Mol Biol. 2018 Oct; 2018 Sep 17. PMID: 30224736.
• Novel ecto-tagged integrins reveal their trafficking in live cells.Huet-Calderwood C, Rivera-Molina F, Iwamoto DV, Kromann EB, Toomre D, Calderwood DA. Nat Commun. 2017 Sep 18; 2017 Sep 18. PMID: 28924207.
• Nuclear Localization of Integrin Cytoplasmic Domain-associated Protein-1 (ICAP1) Influences β1 Integrin Activation and Recruits Krev/Interaction Trapped-1 (KRIT1) to the Nucleus.Draheim KM, Huet-Calderwood C, Simon B, Calderwood DA. J Biol Chem. 2017 Feb 3; 2016 Dec 21. PMID: 28003363.
• Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms.Shi X, Mihaylova VT, Kuruvilla L, Chen F, Viviano S, Baldassarre M, Sperandio D, Martinez R, Yue P, Bates JG, Breckenridge DG, Schlessinger J, Turk BE, Calderwood DA. Proc Natl Acad Sci U S A. 2016 Aug 2; 2016 Jul 18. PMID: 27432991.
• PAK6 targets to cell-cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape.Morse EM, Sun X, Olberding JR, Ha BH, Boggon TJ, Calderwood DA. J Cell Sci. 2016 Jan 15; 2015 Nov 23. PMID: 26598554.
• The Rap1-RIAM pathway prefers β2 integrins.Calderwood DA. Blood. 2015 Dec 17. PMID: 26679542.
• Regulation of integrin-mediated adhesions.Iwamoto DV, Calderwood DA. Curr Opin Cell Biol. 2015 Oct; 2015 Jul 17. PMID: 26189062.
• CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation.Draheim KM, Li X, Zhang R, Fisher OS, Villari G, Boggon TJ, Calderwood DA. J Cell Biol. 2015 Mar 30. PMID: 25825518.
• Direct interactions with the integrin β1 cytoplasmic tail activate the Abl2/Arg kinase.Simpson MA, Bradley WD, Harburger D, Parsons M, Calderwood DA, Koleske AJ. J Biol Chem. 2015 Mar 27; 2015 Feb 18. PMID: 25694433.
• Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function.Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood DA, Schwartz M, Simons M, Sessa WC, Kyriakides TR. J Biol Chem. 2015 Jan 2; 2014 Nov 11. PMID: 25389299.
• The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering.Ellis SJ, Lostchuck E, Goult BT, Bouaouina M, Fairchild MJ, López-Ceballos P, Calderwood DA, Tanentzapf G. PLoS Genet. 2014 Nov; 2014 Nov 13. PMID: 25393120.
• Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation.Huet-Calderwood C, Brahme NN, Kumar N, Stiegler AL, Raghavan S, Boggon TJ, Calderwood DA. J Cell Sci. 2014 Oct 1; 2014 Aug 1. PMID: 25086068.
• TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly.Uchil PD, Pawliczek T, Reynolds TD, Ding S, Hinz A, Munro JB, Huang F, Floyd RW, Yang H, Hamilton WL, Bewersdorf J, Xiong Y, Calderwood DA, Mothes W. J Cell Sci. 2014 Sep 15; 2014 Jul 11. PMID: 25015296.
• Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis.Lee MY, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano AK, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood DA, Ferguson SM, De Camilli P, Sessa WC. Development. 2014 Apr; 2014 Mar 5. PMID: 24598168.
• Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance.Tian X, Kim JJ, Monkley SM, Gotoh N, Nandez R, Soda K, Inoue K, Balkin DM, Hassan H, Son SH, Lee Y, Moeckel G, Calderwood DA, Holzman LB, Critchley DR, Zent R, Reiser J, Ishibe S. J Clin Invest. 2014 Mar; 2014 Feb 17. PMID: 24531545.
• Cerebral cavernous malformation proteins at a glance.Draheim KM, Fisher OS, Boggon TJ, Calderwood DA. J Cell Sci. 2014 Feb 15; 2014 Jan 30. PMID: 24481819.
• Integrin cytoplasmic tail interactions.Morse EM, Brahme NN, Calderwood DA. Biochemistry. 2014 Feb 11; 2014 Jan 27. PMID: 24467163.
• Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics.Brahme NN, Harburger DS, Kemp-O'Brien K, Stewart R, Raghavan S, Parsons M, Calderwood DA. J Biol Chem. 2013 Dec 6; 2013 Oct 28. PMID: 24165133.
• ASB2α, an E3 ubiquitin ligase specificity subunit, regulates cell spreading and triggers proteasomal degradation of filamins by targeting the filamin calponin homology 1 domain.Razinia Z, Baldassarre M, Cantelli G, Calderwood DA. J Biol Chem. 2013 Nov 1; 2013 Sep 19. PMID: 24052262.
• Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6.Gao J, Ha BH, Lou HJ, Morse EM, Zhang R, Calderwood DA, Turk BE, Boggon TJ. PLoS One. 2013; 2013 Oct 28. PMID: 24204982.
• Talins and kindlins: partners in integrin-mediated adhesion.Calderwood DA, Campbell ID, Critchley DR. Nat Rev Mol Cell Biol. 2013 Aug; 2013 Jul 17. PMID: 23860236.
• Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.Liu W, Draheim KM, Zhang R, Calderwood DA, Boggon TJ. Mol Cell. 2013 Feb 21; 2013 Jan 11. PMID: 23317506.
• Purification and SAXS analysis of the integrin linked kinase, PINCH, parvin (IPP) heterotrimeric complex.Stiegler AL, Grant TD, Luft JR, Calderwood DA, Snell EH, Boggon TJ. PLoS One. 2013; 2013 Jan 31. PMID: 23383235.
• Structural and functional characterization of the kindlin-1 pleckstrin homology domain.Yates LA, Lumb CN, Brahme NN, Zalyte R, Bird LE, De Colibus L, Owens RJ, Calderwood DA, Sansom MS, Gilbert RJ. J Biol Chem. 2012 Dec 21; 2012 Nov 6. PMID: 23132860.
• Zasp regulates integrin activation.Bouaouina M, Jani K, Long JY, Czerniecki S, Morse EM, Ellis SJ, Tanentzapf G, Schöck F, Calderwood DA. J Cell Sci. 2012 Dec 1; 2012 Sep 19. PMID: 22992465.
• Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension.Coyer SR, Singh A, Dumbauld DW, Calderwood DA, Craig SW, Delamarche E, García AJ. J Cell Sci. 2012 Nov 1; 2012 Aug 16. PMID: 22899715.
• Structural basis for paxillin binding and focal adhesion targeting of β-parvin.Stiegler AL, Draheim KM, Li X, Chayen NE, Calderwood DA, Boggon TJ. J Biol Chem. 2012 Sep 21; 2012 Aug 6. PMID: 22869380.
• Cell adhesion: a FERM grasp of the tail sorts out integrins.Brahme NN, Calderwood DA. Curr Biol. 2012 Sep 11. PMID: 22974999.
• Filamin A controls matrix metalloproteinase activity and regulates cell invasion in human fibrosarcoma cells.Baldassarre M, Razinia Z, Brahme NN, Buccione R, Calderwood DA. J Cell Sci. 2012 Aug 15; 2012 May 17. PMID: 22595522.
• Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1).Li X, Zhang R, Draheim KM, Liu W, Calderwood DA, Boggon TJ. J Biol Chem. 2012 Jun 22; 2012 May 10. PMID: 22577140.
• Functional differences between kindlin-1 and kindlin-2 in keratinocytes.Bandyopadhyay A, Rothschild G, Kim S, Calderwood DA, Raghavan S. J Cell Sci. 2012 May 1; 2012 Feb 10. PMID: 22328497.
• Macrophage mesenchymal migration requires podosome stabilization by filamin A.Guiet R, Vérollet C, Lamsoul I, Cougoule C, Poincloux R, Labrousse A, Calderwood DA, Glogauer M, Lutz PG, Maridonneau-Parini I. J Biol Chem. 2012 Apr 13; 2012 Feb 9. PMID: 22334688.
• A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.Bouaouina M, Goult BT, Huet-Calderwood C, Bate N, Brahme NN, Barsukov IL, Critchley DR, Calderwood DA. J Biol Chem. 2012 Mar 2; 2012 Jan 10. PMID: 22235127.
• FAK promotes recruitment of talin to nascent adhesions to control cell motility.Lawson C, Lim ST, Uryu S, Chen XL, Calderwood DA, Schlaepfer DD. J Cell Biol. 2012 Jan 23. PMID: 22270917.
• Filamins in mechanosensing and signaling.Razinia Z, Mäkelä T, Ylänne J, Calderwood DA. Annu Rev Biophys. 2012; 2012 Feb 23. PMID: 22404683.
• Talin and signaling through integrins.Bouaouina M, Harburger DS, Calderwood DA. Methods Mol Biol. 2012. PMID: 21909921.
• Functional and structural insights into ASB2alpha, a novel regulator of integrin-dependent adhesion of hematopoietic cells.Lamsoul I, Burande CF, Razinia Z, Houles TC, Menoret D, Baldassarre M, Erard M, Moog-Lutz C, Calderwood DA, Lutz PG. J Biol Chem. 2011 Sep 2; 2011 Jul 7. PMID: 21737450.
• The E3 ubiquitin ligase specificity subunit ASB2α targets filamins for proteasomal degradation by interacting with the filamin actin-binding domain.Razinia Z, Baldassarre M, Bouaouina M, Lamsoul I, Lutz PG, Calderwood DA. J Cell Sci. 2011 Aug 1; 2011 Jul 12. PMID: 21750192.
• Kindlins.Bouaouina M, Calderwood DA. Curr Biol. 2011 Feb 8. PMID: 21300280.
• Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase.Chiswell BP, Stiegler AL, Razinia Z, Nalibotski E, Boggon TJ, Calderwood DA. J Struct Biol. 2010 Apr; 2009 Dec 4. PMID: 19963065.
• Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.Goult BT, Bouaouina M, Elliott PR, Bate N, Patel B, Gingras AR, Grossmann JG, Roberts GC, Calderwood DA, Critchley DR, Barsukov IL. EMBO J. 2010 Mar 17; 2010 Feb 11. PMID: 20150896.
• The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation.Goult BT, Bouaouina M, Harburger DS, Bate N, Patel B, Anthis NJ, Campbell ID, Calderwood DA, Barsukov IL, Roberts GC, Critchley DR. J Mol Biol. 2009 Dec 18; 2009 Oct 3. PMID: 19804783.
• Filamins regulate cell spreading and initiation of cell migration.Baldassarre M, Razinia Z, Burande CF, Lamsoul I, Lutz PG, Calderwood DA. PLoS One. 2009 Nov 13; 2009 Nov 13. PMID: 19915675.
• Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension.Gehler S, Baldassarre M, Lad Y, Leight JL, Wozniak MA, Riching KM, Eliceiri KW, Weaver VM, Calderwood DA, Keely PJ. Mol Biol Cell. 2009 Jul; 2009 May 20. PMID: 19458194.
• The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation.Bello NF, Lamsoul I, Heuzé ML, Métais A, Moreaux G, Calderwood DA, Duprez D, Moog-Lutz C, Lutz PG. Cell Death Differ. 2009 Jun; 2009 Mar 20. PMID: 19300455.
• Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects.Harburger DS, Bouaouina M, Calderwood DA. J Biol Chem. 2009 Apr 24; 2009 Feb 23. PMID: 19240021.
• The role of FilGAP-filamin A interactions in mechanoprotection.Shifrin Y, Arora PD, Ohta Y, Calderwood DA, McCulloch CA. Mol Biol Cell. 2009 Mar; 2009 Jan 14. PMID: 19144823.
• Integrin signalling at a glance.Harburger DS, Calderwood DA. J Cell Sci. 2009 Jan 15. PMID: 19118207.
• The structural basis of integrin-linked kinase-PINCH interactions.Chiswell BP, Zhang R, Murphy JW, Boggon TJ, Calderwood DA. Proc Natl Acad Sci U S A. 2008 Dec 30; 2008 Dec 12. PMID: 19074270.
• JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation.Luissint AC, Lutz PG, Calderwood DA, Couraud PO, Bourdoulous S. J Cell Biol. 2008 Dec 15; 2008 Dec 8. PMID: 19064666.
• ASB2 targets filamins A and B to proteasomal degradation.Heuzé ML, Lamsoul I, Baldassarre M, Lad Y, Lévêque S, Razinia Z, Moog-Lutz C, Calderwood DA, Lutz PG. Blood. 2008 Dec 15; 2008 Sep 17. PMID: 18799729.
• Structural basis of the migfilin-filamin interaction and competition with integrin beta tails.Lad Y, Jiang P, Ruskamo S, Harburger DS, Ylänne J, Campbell ID, Calderwood DA. J Biol Chem. 2008 Dec 12; 2008 Sep 30. PMID: 18829455.
• The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate beta1 and beta3 integrins.Bouaouina M, Lad Y, Calderwood DA. J Biol Chem. 2008 Mar 7; 2007 Dec 28. PMID: 18165225.
• Structure of three tandem filamin domains reveals auto-inhibition of ligand binding.Lad Y, Kiema T, Jiang P, Pentikäinen OT, Coles CH, Campbell ID, Calderwood DA, Ylänne J. EMBO J. 2007 Sep 5; 2007 Aug 9. PMID: 17690686.
• Forces and bond dynamics in cell adhesion.Evans EA, Calderwood DA. Science. 2007 May 25. PMID: 17525329.
• Integrin cytoskeletal interactions.Lad Y, Harburger DS, Calderwood DA. Methods Enzymol. 2007. PMID: 17697880.
• Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.Han J, Lim CJ, Watanabe N, Soriani A, Ratnikov B, Calderwood DA, Puzon-McLaughlin W, Lafuente EM, Boussiotis VA, Shattil SJ, Ginsberg MH. Curr Biol. 2006 Sep 19. PMID: 16979556.
• Integrins in the ovary.Monniaux D, Huet-Calderwood C, Le Bellego F, Fabre S, Monget P, Calderwood DA. Semin Reprod Med. 2006 Sep. PMID: 16944422.
• The molecular basis of filamin binding to integrins and competition with talin.Kiema T, Lad Y, Jiang P, Oxley CL, Baldassarre M, Wegener KL, Campbell ID, Ylänne J, Calderwood DA. Mol Cell. 2006 Feb 3. PMID: 16455489.
• Competition for talin results in trans-dominant inhibition of integrin activation.Calderwood DA, Tai V, Di Paolo G, De Camilli P, Ginsberg MH. J Biol Chem. 2004 Jul 9; 2004 May 13. PMID: 15143061.
• Talin controls integrin activation.Calderwood DA. Biochem Soc Trans. 2004 Jun. PMID: 15157154.
• The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion.Kloeker S, Major MB, Calderwood DA, Ginsberg MH, Jones DA, Beckerle MC. J Biol Chem. 2004 Feb 20; 2003 Nov 21. PMID: 14634021.
• Integrin activation.Calderwood DA. J Cell Sci. 2004 Feb 15. PMID: 14754902.
• Talin binding to integrin beta tails: a final common step in integrin activation.Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, de Pereda JM, Ginsberg MH, Calderwood DA. Science. 2003 Oct 3. PMID: 14526080.
• Talin forges the links between integrins and actin.Calderwood DA, Ginsberg MH. Nat Cell Biol. 2003 Aug. PMID: 12894175.
• Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit.Ulmer TS, Calderwood DA, Ginsberg MH, Campbell ID. Biochemistry. 2003 Jul 15. PMID: 12846579.
• Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.Calderwood DA, Fujioka Y, de Pereda JM, García-Alvarez B, Nakamoto T, Margolis B, McGlade CJ, Liddington RC, Ginsberg MH. Proc Natl Acad Sci U S A. 2003 Mar 4; 2003 Feb 26. PMID: 12606711.
• Structural determinants of integrin recognition by talin.García-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC. Mol Cell. 2003 Jan. PMID: 12535520.
• The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains.Woodside DG, Obergfell A, Talapatra A, Calderwood DA, Shattil SJ, Ginsberg MH. J Biol Chem. 2002 Oct 18; 2002 Aug 8. PMID: 12171941.
• The phosphotyrosine binding-like domain of talin activates integrins.Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, Liddington RC, Ginsberg MH. J Biol Chem. 2002 Jun 14; 2002 Apr 3. PMID: 11932255.
• Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration.Calderwood DA, Huttenlocher A, Kiosses WB, Rose DM, Woodside DG, Schwartz MA, Ginsberg MH. Nat Cell Biol. 2001 Dec. PMID: 11781567.
• PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase.Formstecher E, Ramos JW, Fauquet M, Calderwood DA, Hsieh JC, Canton B, Nguyen XT, Barnier JV, Camonis J, Ginsberg MH, Chneiweiss H. Dev Cell. 2001 Aug. PMID: 11702783.
• Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain.Yan B, Calderwood DA, Yaspan B, Ginsberg MH. J Biol Chem. 2001 Jul 27; 2001 May 29. PMID: 11382782.
• Distinct domains of CD98hc regulate integrins and amino acid transport.Fenczik CA, Zent R, Dellos M, Calderwood DA, Satriano J, Kelly C, Ginsberg MH. J Biol Chem. 2001 Mar 23; 2000 Dec 19. PMID: 11121428.
• Integrin cytoplasmic domain-binding proteins.Liu S, Calderwood DA, Ginsberg MH. J Cell Sci. 2000 Oct. PMID: 11017872.
• Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling.Calderwood DA, Shattil SJ, Ginsberg MH. J Biol Chem. 2000 Jul 28. PMID: 10801899.
• Class- and splice variant-specific association of CD98 with integrin beta cytoplasmic domains.Zent R, Fenczik CA, Calderwood DA, Liu S, Dellos M, Ginsberg MH. J Biol Chem. 2000 Feb 18. PMID: 10671548.
• The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation.Calderwood DA, Zent R, Grant R, Rees DJ, Hynes RO, Ginsberg MH. J Biol Chem. 1999 Oct 1. PMID: 10497155.
• Molecular characterisation of integrin-procollagen C-propeptide interactions.Davies D, Tuckwell DS, Calderwood DA, Weston SA, Takigawa M, Humphries MJ. Eur J Biochem. 1997 Jun 1. PMID: 9208915.