Publications

Meningoencephalitis of unknown origin in dogs under veterinary referral care in England (2017-2021): a multicenter case control study.Choi Y, O'Neill DG, Ives E, Brown TH, Lopes BA, Alves LC, Cardy T, Ruggeri M, Tauro A, Cherubini GB, Lowrie M, Saunders L, Granger N, Stefaniuk M, Cappello R, Trevail R, Adamantos S, Gonçalves R, De Decker S, Fadda A. Front Vet Sci. 2025; 2025 Nov 26. PMID: 41383969.
Revisiting the autoconditioning hypothesis for acquired reactivity to ultrasonic alarm calls.Calub CA, Furtak SC, Brown TH. Physiol Behav. 2018 Oct 1; 2018 Jun 19. PMID: 29933032.
Dual functions of perirhinal cortex in fear conditioning.Kent BA, Brown TH. Hippocampus. 2012 Oct; 2012 Aug 18. PMID: 22903623.
Rats learn to freeze to 22-kHz ultrasonic vocalizations through autoconditioning.Parsana AJ, Moran EE, Brown TH. Behav Brain Res. 2012 Jul 1; 2012 Mar 28. PMID: 22475554.
Muscarinic receptor activation enables persistent firing in pyramidal neurons from superficial layers of dorsal perirhinal cortex.Navaroli VL, Zhao Y, Boguszewski P, Brown TH. Hippocampus. 2012 Jun; 2011 Sep 28. PMID: 21956787.
Muscarinic receptors in amygdala control trace fear conditioning.Baysinger AN, Kent BA, Brown TH. PLoS One. 2012; 2012 Sep 21. PMID: 23029199.
Positive and negative ultrasonic social signals elicit opposing firing patterns in rat amygdala.Parsana AJ, Li N, Brown TH. Behav Brain Res. 2012 Jan 1; 2011 Sep 3. PMID: 21911010.
Aging-related changes in calcium-binding proteins in rat perirhinal cortex.Moyer JR Jr, Furtak SC, McGann JP, Brown TH. Neurobiol Aging. 2011 Sep; 2009 Nov 4. PMID: 19892435.
Perirhinal cortex supports acquired fear of auditory objects.Bang SJ, Brown TH. Neurobiol Learn Mem. 2009 Jul; 2009 Jan 29. PMID: 19185613.
Muscarinic receptors in perirhinal cortex control trace conditioning.Bang SJ, Brown TH. J Neurosci. 2009 Apr 8. PMID: 19357262.
Asymmetrical stimulus generalization following differential fear conditioning.Bang SJ, Allen TA, Jones LK, Boguszewski P, Brown TH. Neurobiol Learn Mem. 2008 Jul; 2008 Apr 22. PMID: 18434217.
Imaging the spread of reversible brain inactivations using fluorescent muscimol.Allen TA, Narayanan NS, Kholodar-Smith DB, Zhao Y, Laubach M, Brown TH. J Neurosci Methods. 2008 Jun 15; 2008 Mar 10. PMID: 18377997.
Morphology and ontogeny of rat perirhinal cortical neurons.Furtak SC, Moyer JR Jr, Brown TH. J Comp Neurol. 2007 Dec 10. PMID: 17924570.
Single-unit firing in rat perirhinal cortex caused by fear conditioning to arbitrary and ecological stimuli.Furtak SC, Allen TA, Brown TH. J Neurosci. 2007 Nov 7. PMID: 17989293.
Single-unit responses to 22 kHz ultrasonic vocalizations in rat perirhinal cortex.Allen TA, Furtak SC, Brown TH. Behav Brain Res. 2007 Sep 4; 2007 Mar 16. PMID: 17445914.
Impaired trace and contextual fear conditioning in aged rats.Moyer JR Jr, Brown TH. Behav Neurosci. 2006 Jun. PMID: 16768613.
Neurophysiological theory of kamin blocking in fear conditioning.Padlubnaya DB, Parekh NH, Brown TH. Behav Neurosci. 2006 Apr. PMID: 16719698.

2000-2005

Tankhiwale, A. A., and Brown, T. H. Temporal lobe and object recognition. Thompson, R.F, Shors, T. J. (eds.) Encyclopedia of Behavioral Neuroscience. Oxford: Elsevier. in press.
Brown, T.H. Furtak, S.C. and Lindquist, D.H. Hebbian Synapses. In Encyclopedia of Neuroscience (3rd ed.) eds: Adelman, G. and Smith, B.H. (Eds.), New York, NY : Elsevier Science, 2004.
Brown, T.H., and Lindquist, D.H. Long-term Potentiation: Amygdala. In Learning and Memory, 2nd Ed.), ed: Byrne, J.H., Farmington Hills, MI: Macmillan Reference, pp. 342-46, 2003.
Brown, T.H., Byrne, J.H, Labar, K., LeDoux, J., Lindquist, D.H., Thompson, R.F., and Teyler, T.J. Learning and memory: Basic mechanisms. In Cellular and Molecular Neuroscience. eds: Byrne, J.H. and Roberts, J.L. San Diego, CA: Academic Press, pp. 499-574, 2003.
Moyer, J.R., Jr. and Brown, T.H. Patch-clamp techniques applied to brain slices. In: Advanced Techniques for Patch-Clamp Analysis, eds: W. Walz, A.A. Boulton, & G.B. Baker, Totowa, NJ: Humana Press, pp. 135-194, 2002.
Choi, J-S., Lindquist, D.H., and Brown, T.H. Amygdala lesions block conditioned enhancement of the early component of the rat eyeblink reflex. Behavioral Neuroscience, 115 (4): 764-775, 2001.
Lee, H.J., Choi, J-S., Brown, T.H., and Kim, J.J. Amygdalar N-Methyl-D-Aspartate (NMDA) receptors are critical for the expression of multiple conditioned fear responses. J. Neuroscience, 21(11): 4116-4124, 2001.
McGann, J.P., Moyer, J.R., Jr., and Brown, T.H. Predominance of late-spiking neurons in layer VI of rat perirhinal cortex. J. Neuroscience,21(14): 4969- 4976, 2001.
McGann, J.P. and Brown, T.H. Fear conditioning model predicts key temporal aspects of conditioned response production. Psychobiology, 28 (3): 303-313, 2000.
Beggs, J.M., Moyer, J.R., McGann, J.P., Brown, T.H. Prolonged synaptic integration in perirhinal cortical neurons. J Neurophysiol, 83: 3294-3298, 2000.

1995-1999

Beggs, J. M., Brown, T. H., Byrne, J. H., Crow, T., LeDoux, J. E., LeBar, K., and Thompson, R. F. Learning and memory: Basic mechanisms and systems. In: Fundamentals of Neuroscience, M. J. Zigmond, F. E. Bloom, S. C. Landis, J. L. Roberts, L. S. Squire (eds.), Academic Press, San Diego, CA. pp. 1411-1454, 1999.
Faulkner, B. and Brown, T. H. Morphology and physiology of neurons in the rat perirhinal-lateral amygdala area. J. Comp. Neurol., 411: 613-642, 1999.
Brown, T. H. and Faulkner, B. Hebbian synapses. In: Encyclopedia of Neuroscience, G. Adelman and B. Smith, (eds.), on CD-ROM, 1999. 865-868, Amsterham, Netherlands, 1999.
Greenwood, A. C., Landaw, E. M., and Brown, T. H. Testing the fit of a quantal model of neurotransmission. Biophys. J., 76: 1847-1855, 1999.
Tieu, K. H., Keidel, A. L., McGann, J. P., Faulkner, B., and Brown, T. H. Perirhinal-amygdala circuit-level computational model of temporal encoding in fear conditioning. Psychobiology, 27: 1-25, 1999.
Moyer, J. R. and Brown, T. H. Methods for whole-cell recording from visually preselected neurons of perirhinal cortex in brain slices from young and aging rats. J. Neurosci. Meth., 86 (1): 35-54, 1998. abstract
Xiang, Z. and Brown, T. H. Complex synaptic current waveforms evoked in hippocampal pyramidal neurons by extracellular stimulation of dentate gyrus. J. Neurophysiol., 79: 2475-2484, 1998.
Faulkner, B., Brown, T. H., and Evinger, C. Identification and characterization of rat orbicularis oculi motoneurons using confocal laser scanning microscopy. Exp. Brain Res., 116: 10-19, 1997.
Faulkner, B., Tieu, K. H., and Brown, T. H. Mechanism for temporal encoding in fear conditioning: delay lines in perirhinal cortex and lateral amygdala. Computational Neuroscience, J. Bower (ed.), Plenum Publishing Corp., New York, NY. pp. 641-645, 1997.
Jaffe, D. B. and Brown, T. H. Calcium dynamics in thorny excrescences of CA3 pyramidal neurons. J. Neurophysiol., 78: 10-18, 1997.
Carnevale, N. T., Tsai, K. Y., Claiborne, B. J., and Brown, T. H. Comparative electrotonic analysis of three classes of rat hippocampal neurons. J. Neurophysiol., 78: 703-720, 1997.
Lam, Y.-W., Wong, A., Canli, T., and Brown, T. H. Conditioned enhancement of the early component of the rat eyeblink reflex. Neurobiol. Learn. Mem ., 66: 212-220, 1996.
Mainen, Z. F., Carnevale, N. T., Zador, A. M., Claiborne, B. J., and Brown, T. H. Electrotonic architecture of hippocampal CA1 pyramidal neurons based on three-dimensional reconstructions. J. Neurophysiol., 76 (3): 1904-23, 1996. abstract
Canli, T. and Brown, T. H. Amygdala stimulation enhances the rat eyeblink reflex through a short latency mechanism. Behav. Neurosci., 110 (1): 51-9, 1996.
O'Boyle, M. P., Carnevale, N. T., Claiborne, B. J., and Brown, T. H. A new graphical approach for visualizing the relationship between anatomical and electrotonic structure. In: Computational Neuroscience, J. Bower (ed.), pp. 423-28, Academic Press, San Diego, CA, 1996.
Carnevale, N. T., Tsai, K. Y., Claiborne, B. J., and Brown, T. H. Qualitative electrotonic comparison of three classes of hippocampal neurons in the rat. In: The Neurobiology of Computation, J. Bower (ed.), pp. 67-72, Kluwer, Boston, MA, 1995.
Carnevale, N. T., Tsai, K. Y., Claiborne, B. J., and Brown, T. H. The electrotonic transformation: a tool for relating neuronal form to function. In: Advances in Neural Information Processing Systems 7, G. Tesauro, D. S. Touretzky, and J. Alspector, (eds.), pp. 69-76, Morgan Kaufmann , San Mateo, CA, 1995.
Brown, T. H. and Chattarji, S. Hebbian plasticity. In: The Handbook of Brain Theory and Neural Networks, M. A. Arbib (ed.), pp. 454-459, MIT Press, 1995.

1990-1994

Brown, T. H. and Jaffe, D. B. Calcium imaging in hippocampal neurons using confocal microscopy. Annl. N.Y. Acad. Sci., 747:313-324, 1994.
Jaffe, D. B. and Brown, T. H. Confocal imaging of dendritic Ca2+ transients in hippocampal brain slices during simultaneous current- and voltage-clamp recordings. J. Microscopy Res. Tech., 29:279-289, 1994.
Jaffe, D. B. and Brown, T. H. Metabotropic glutamate receptor activation induces calcium waves within dendrites of hippocampal neurons. J. Neurophysiol., 72:471-474, 1994.
Jaffe, D. B., Fisher, S. A., and Brown, T. H. Confocal laser scanning microscopy reveals voltage-gated calcium signals within hippocampal dendritic spines. J. Neurobiol., 25(3):220-233, 1994.
Tsai, K. Y., Carnevale, N. T. and Brown, T. H. Efficient mapping from neuroanatomical to electrotonic space. Network: Computation in Neural Systems, 5:21-46, 1994.
Xiang, Z, Greenwood, A. C., Kairiss, E. W., and Brown, T. H. Quantal mechanisms of long-term potentiation in hippocampal mossy-fiber synapses. J. Neurophysiol. 71:2552-2556, 1994.
Tsai, K. Y., Carnevale, N. T., and Brown, T. H. Hebbian learning is jointly controlled by electrotonic and input structure. Network: Computation in Neural Systems, 5:1-19, 1994.
Brown, T. H. and Chattarji, S. Hebbian synaptic plasticity: evolution of the contemporary concept. Models of Neural Networks II , E. Domany, J. L. Van Hemmen, and K. Schulten (eds.), pp. 287-314, Springer-Verlag, New York, 1994.
Yu, T.-P. and Brown, T. H. Three-dimensional quantification of mossy-fiber presynaptic boutons in living hippocampal slices using confocal microscopy. Synapse, 18:190-197, 1994
Claiborne, B. J., Xiang, Z., and Brown, T. H. Hippocampal circuitry complicates analysis of long-term potentiation in mossy fiber synapses. Hippocampus, 3:115-122, 1993.
Claiborne, B. J., Zador, A. M., Mainen, Z. F., and Brown, T. H. Computational models of hippocampal neurons. In: Single Neuron Computation, T. McKenna, J. Davis, and S. F.
Zornetzer (eds.), pp. 61-79, Academic Press, 1992.
Koch, C., Zador, A. M., and Brown, T. H. Dendritic spines: Convergence of theory and experiment, Science, 256: 973-4, 1992.
Zador, A. M., Claiborne, B. J., and Brown, T. H. Nonlinear pattern separation in single hippocampal neurons with active dendritic membrane. In: Advances in Neural Information Processing Systems 4, J. E. Moody, S. J. Hanson, and R. P. Lippmann (eds.), pp. 51-58, Morgan Kaufmann, 1992.
Brown, T. H., Zador, A. M., Mainen, Z. F., and Claiborne, B. J. Self-organization of Hebbian synapses in hippocampal neurons. In: Advances in Neural Information Processing Systems 3, R. Lippmann, J. Moody, D. Touretzky (eds.), pp. 39-45, Morgan Kaufmann Publishers, 1991.
Brown, T. H. and Zador, A. M. The hippocampus. In: Synaptic Organization of the Brain, G. Shepherd (ed.), pp. 346-388, Oxford, 1990.
Brown, T. H., Kairiss, E. W., and Keenan, C. L. Hebbian synapses–biophysical mechanisms and algorithms. Ann. Rev. Neurosci., 13:475-511, 1990.
Chapman, P. F., Kairiss, E. W., Keenan, C. L., and Brown, T. H. Long-term synaptic potentiation in the amygdala. Synapse, 6: 271-278, 1990. abstract
Zador, A. M., Koch, C., and Brown, T. H. Biophysical model of a Hebbian synapse, Proc. Natl. Acad. Sci., 87: 6718-6722, 1990. full text
Kairiss, E. W., Mainen, Z. F., Claiborne, B. J., and Brown, T. H. Dendritic control of Hebbian computations. In: Analysis and Modeling of Neural Systems, F. Beckman (ed.), pp. 69-83, Kluwer Academic Publishers, 1991. full text
Brown, T. H., Zador, A. M., Mainen, Z. F., and Claiborne, B. J. Hebbian computations in hippocampal dendrites and spines. In: Single Neuron Computation, T. McKenna, J. Davis, and S. F. Zornetzer (eds.), pp. 81-116, Academic Press, 1992. full text
Brown, T. H., Zador, A. M., Mainen, Z. F., and Claiborne, B. J. Hebbian modifications in hippocampal neurons. In: Long-Term Potentiation: A Debate of Current Issues, J. Davis and M. Baudry (eds.), pp. 357-389, MIT Press, 1991.
Chapman, P. F., Kairiss, E. W., Keenan, C. L., and Brown, T. H. Long-term synaptic potentiation in the amygdala. Synapse, 6: 271-278, 1990.

1985-1989

Brown, T. H., Ganong, A. H., Kairiss, E. W., Keenan, C. L., and Kelso, S. R. Long-term potentiation in two synaptic systems of the hippocampal brain slice. In: Neural Models of Plasticity, J. H. Byrne and W. O. Berry (eds.), pp. 266-306, Academic Press, 1989.
Brown, T. H., Chang, V. C., Ganong, A. H., Keenan, C. L., and Kelso, S. R. Biophysical properties of dendrites and spines that may control the induction and expression of long-term synaptic potentiation. In: Long-Term Potentiation: From Biophysics to Behavior, P.W. Landfield and S. Deadwyler (eds.), pp. 201-264, Alan R. Liss, 1988.
Brown, T. H., Chapman, P. F., Kairiss, E. W., and Keenan, C. L. Long-term synaptic potentiation. Science, 242: 724-728, 1988. abstract
Keenan, C. L., Chapman, P. F., Chang, V. C., and Brown, T. H. Videomicroscopy of acute brain slices from hippocampus and amygdala. Brain Res. Bull., 21: 373-383, 1988. abstract
Johnston, D. and Brown, T. H. Control theory applied to neural networks illuminates synaptic basis of interictal epileptiform activity. In: Advances in Neurology, Vol. 44. Basic Mechanisms of Epilepsies. Molecular and Cellular Approaches, A. B. Delgado-Escueta, A. A. Ward, D. M. Woodbury and R. J. Porter (eds.), pp. 263-274, Raven Press, 1986. abstract
Barrionuevo, G., Kelso, S., Johnston, D., and Brown, T. H. Conductance mechanism responsible for long-term potentiation in monosynaptic and isolated excitatory synaptic inputs to hippocampus. J. Neurophysiol., 55:540-550, 1986. abstract
Griffith, W. H., Brown, T. H., and Johnston, D. Voltage-clamp analysis of synaptic inhibition during long-term potentiation in hippocampus. J. Neurophysiol., 55:767-775, 1986. abstact
Kelso, S. and Brown, T. H. Differential conditioning of associative synaptic enhancement in hippocampal brain slices. Science, 232:85-87, 1986. abstract
Kelso, S., Ganong, A., and Brown, T. H. Hebbian synapses in hippocampus. Proc. Natl. Acad. Sci., 83:5326-5330, 1986. full text
Baxter, D., Bittner, G. D., and Brown, T. H. Quantal mechanism of long-term synaptic potentiation. Proc. Natl. Acad. Sci., 82:5978-5982, 1985.
Briggs, C. A., Brown, T. H., and McAfee, D. A. Neurophysiology and pharmacology of long-term potentiation in the rat sympathetic ganglion. J. Physiol. 359:503-52l, l985.

1980-1984

Johnston, D. and Brown, T. H. The synaptic nature of the paroxysmal depolarizing shift in hippocampal neurons. Annals of Neurology, 16(S1):S65-S71, 1984.
Johnston, D. and Brown, T. H. Mechanisms of neuronal burst generation. In: Electrophysiology of Epilepsy, P. A. Schwarzkroin and H. V. Wheal (eds.), pp. 277-301. Academic Press, 1984.
Johnston, D. and Brown, T. H. Biophysics and microphysiology of synaptic transmission in hippocampus. In: Brain Slices, R. Dingledine (ed.), pp. 51-86, Plenum Press, 1984.
Johnston, D. and Brown, T. H. Interpretation of voltage-clamp measurements of hippocampal neurons. J. Neurophysiol., 50:464-486, 1983.
Barrionuevo, G. and Brown, T. H. Associative long-term synaptic potentiation in hippocampal slices. Proc. Natl. Acad. Sci., 80:7347-7351, 1983. full text
Brown, T. H. and Johnston, D. Voltage-clamp analysis of mossy-fiber synaptic input to hippocampal neurons. J. Neurophysiol., 50:487-507, 1983.
Brown, T. H. and McAfee, D. Long-term synaptic potentiation in superior cervical ganglion. Science, 215:1411-1413, 1982. abstract
Johnston, D. and Brown, T. H. Giant synaptic potential hypothesis for epileptiform activity. Science, 211:294-297, 1981. abstract
Brown, T. H., Perkel, D. H., Norris, J. C., and Peacock, J. H. Electrotonic structure and specific membrane properties of mouse dorsal-root ganglion neurons. J. Neurophysiol., 45:1-15, 1981.
Brown, T. H., Fricke, R. A., and Perkel, D. H. Passive electrical constants in three classes of hippocampal neurons. J. Neurophysiol., 46:812-827, 1981.
Brown, T. H. and Newby, N. A. Quantal nature of neuromuscular transmission in crayfish phasic abdominal flexors. J. Comp. Physiol., 136:89-101, 1980.

1975-1979

Noble, M. D., Brown, T. H., and Peacock, J. H. Direct effects of neostigmine on aneural myotube cultures. Neurosci. Lett., 11:149-154, 1979.
Brown, T. H., Wong, R. K. S., and Prince, D. A. Spontaneous miniature synaptic potentials in hippocampal neurons. Brain Res., 177:194-199, 1979.
Noble, M. D., Brown, T. H., and Peacock, J. H. Regulation of acetylcholine receptors levels by cholinergic agonist in mouse muscle cell cultures. Proc. Natl. Acad. Sci., 75:3488-3492, 1978.
Brown, T. H., Perkel, D. H., and Feldman, M. W. Evoked neurotransmitter release: Statistical effects of nonuniformity and nonstationarity. Proc. Natl. Acad. Sci., 73:2913-2917, 1976.