Research
Identification of Novel Therapeutic Targets
To identify novel therapeutic targets through:
- Epigenetics basis of GI (gastrointestinal) cancers (gastric cancer, colorectal cancer, pancreas cancer, peritoneal cancer, appendix cancer) and tumor microenvironment
- Identification of epigenetic and genetic changes associated with GI cancers
- Characterization of molecular and cellular mechanisms in the tumor microenvironment associated with disease initiation and progression
- Understanding epigenetic and genetic changes associated with rapid progressors and long terms survivors in pancreatic cancer
- Genetic and epigenetics basis of sarcoma
Advanced NGS data analysis approach to understand and explore complexity of GI cancers
Identification of early detection of biomarkers in GI cancers using next generation liquid biopsy
Characterization of molecular and cellular mechanisms in the tumor
- To understand GI tumor biology through developing models to dissect components of the tumor micro-environment associated with disease initiation and progression through the use of in vitro organoids in multiple disease models.
Nanoparticle based drug delivery in solid tumors
- Address the urgent need for better utilization of existing drugs by developing solid tumor in vivo system to elucidate the use of bioadhesive nanoparticles in therapeutics