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Publications

Our lab has produced seminal research on aging, epigenetics, and the development of non-invasive liquid biopsy-based biomarkers for the early detection of cancers. These papers underscore our commitment to advancing cancer research and improving patient care through innovative approaches.

Highlights include:

  • Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells Cancer Cell PMID: 22439938
  • Aging and DNA methylation in colorectal mucosa and cancer Cancer Research PMID: 9850084
  • CpG island methylator phenotype in colorectal cancer PNAS PMID: 10411935

DNA-demethylating agents have a significant effect on tumor cells. Aging affects DNA methylation in colorectal mucosa and cancer. CpG island methylator phenotype is found in colorectal cancer. These findings contribute to the understanding of cancer development and progression, paving the way for innovative approaches in cancer research and patient care.

We are conducting research on how DNA-demethylating agents impact tumor cells. We are also exploring the relationship between aging and DNA methylation in colorectal cancer. Additionally, we are identifying CpG island methylator phenotype in colorectal cancer. These methods may result in new diagnostic and therapeutic strategies.


Publications

Showing 1 - 100 results of 680 publications

2024

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2021