2023
Orbitofrontal cortex microRNAs support long-lasting heroin seeking behavior in male rats
Zanda M, Floris G, Daws S. Orbitofrontal cortex microRNAs support long-lasting heroin seeking behavior in male rats. Translational Psychiatry 2023, 13: 117. PMID: 37031193, PMCID: PMC10082780, DOI: 10.1038/s41398-023-02423-4.Peer-Reviewed Original ResearchConceptsOpioid use disorderOrbitofrontal cortexHL animalsHeroin seekingDrug cravingSelf-administer heroinLong-term heroinMaintenance of abstinenceDrug seeking behaviorOpioid useHeroin cravingMale ratsPreclinical studiesUse disordersDrug useExposure paradigmBrain regionsAbstinence periodAbstinenceHeroinDrug cuesSeeking behaviourLow dosageCravingProteomic analysis
2021
Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence
Zanda M, Floris G, Daws S. Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence. Scientific Reports 2021, 11: 14825. PMID: 34290298, PMCID: PMC8295307, DOI: 10.1038/s41598-021-94214-4.Peer-Reviewed Original ResearchConceptsDrug cuesDrug seekingIncubation of heroin cravingIncubation of opioid cravingDrug self-administration paradigmLow dose of heroinDrug-associated cuesSelf-administration paradigmDoses of heroinDays of abstinenceDrug-taking patternsDrug intake historyHeroin seekingRate of relapseHeroin cravingAbstinence phaseSelf-administrationOpioid cravingOpioid use disorderPromote relapseAbstinence lengthOpioid seekingUse disorderCompletion of rehabilitation programsIntake history