2024
The sinking platform test: a novel paradigm to measure persistence in animal models
Floris G, Godar S, Braccagni G, Piras I, Ravens A, Zanda M, Huentelman M, Bortolato M. The sinking platform test: a novel paradigm to measure persistence in animal models. Neuropsychopharmacology 2024, 49: 1373-1382. PMID: 38396257, PMCID: PMC11251282, DOI: 10.1038/s41386-024-01827-0.Peer-Reviewed Original ResearchConceptsChronic administration of fluoxetinePrefrontal cortex of miceWeeks of social isolationAdministration of fluoxetineMeasure persistenceGoal-directed actionsSocially isolated miceMitigate depression riskCortex of micePlatform testVoluntary wheel runningChronic haloperidolPrefrontal cortexTemperamental traitsImipramine treatmentNeurobiological foundationsBehavioral tasksChronic stressChronic administrationImmediate-early genesFailure TrialWheel runningDepression riskAnimal modelsNovel interventions
2023
Orbitofrontal cortex microRNAs support long-lasting heroin seeking behavior in male rats
Zanda M, Floris G, Daws S. Orbitofrontal cortex microRNAs support long-lasting heroin seeking behavior in male rats. Translational Psychiatry 2023, 13: 117. PMID: 37031193, PMCID: PMC10082780, DOI: 10.1038/s41398-023-02423-4.Peer-Reviewed Original ResearchConceptsOpioid use disorderOrbitofrontal cortexHL animalsHeroin seekingDrug cravingSelf-administer heroinLong-term heroinMaintenance of abstinenceDrug seeking behaviorOpioid useHeroin cravingMale ratsPreclinical studiesUse disordersDrug useExposure paradigmBrain regionsAbstinence periodAbstinenceHeroinDrug cuesSeeking behaviourLow dosageCravingProteomic analysis