2023
Orbitofrontal cortex microRNAs support long-lasting heroin seeking behavior in male rats
Zanda M, Floris G, Daws S. Orbitofrontal cortex microRNAs support long-lasting heroin seeking behavior in male rats. Translational Psychiatry 2023, 13: 117. PMID: 37031193, PMCID: PMC10082780, DOI: 10.1038/s41398-023-02423-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCravingCuesDrug-Seeking BehaviorHeroinMaleMicroRNAsOpioid-Related DisordersPrefrontal CortexRatsRats, Sprague-DawleySelf AdministrationConceptsOpioid use disorderOrbitofrontal cortexHL animalsHeroin seekingDrug cravingSelf-administer heroinLong-term heroinMaintenance of abstinenceDrug seeking behaviorOpioid useHeroin cravingMale ratsPreclinical studiesUse disordersDrug useExposure paradigmBrain regionsAbstinence periodAbstinenceHeroinDrug cuesSeeking behaviourLow dosageCravingProteomic analysis
2022
Heroin Regulates Orbitofrontal Circular RNAs
Floris G, Gillespie A, Zanda M, Dabrowski K, Sillivan S. Heroin Regulates Orbitofrontal Circular RNAs. International Journal Of Molecular Sciences 2022, 23: 1453. PMID: 35163373, PMCID: PMC8836038, DOI: 10.3390/ijms23031453.Peer-Reviewed Original ResearchConceptsHeroin self-administrationOrbitofrontal cortexOpioid use disorderNeurobiological adaptationsSelf-administrationSelf-administer sucroseChronic heroin exposureRat orbitofrontal cortexOpioid-seeking behaviorTreat opioid use disorderHeroin exposureUse disorderBrain regionsOpioid heroinBehavioral responsesMale ratsFemale ratsHeroinSeeking behaviorDrug overdose deathsRatsOverdose deathsOpioidRNA splice variantsCortex
2021
Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence
Zanda M, Floris G, Daws S. Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence. Scientific Reports 2021, 11: 14825. PMID: 34290298, PMCID: PMC8295307, DOI: 10.1038/s41598-021-94214-4.Peer-Reviewed Original ResearchConceptsDrug cuesDrug seekingIncubation of heroin cravingIncubation of opioid cravingDrug self-administration paradigmLow dose of heroinDrug-associated cuesSelf-administration paradigmDoses of heroinDays of abstinenceDrug-taking patternsDrug intake historyHeroin seekingRate of relapseHeroin cravingAbstinence phaseSelf-administrationOpioid cravingOpioid use disorderPromote relapseAbstinence lengthOpioid seekingUse disorderCompletion of rehabilitation programsIntake history
2020
Analysis of Opioid-Seeking Behavior Through the Intravenous Self-Administration Reinstatement Model in Rats
Fattore L, Fadda P, Zanda M, Fratta W. Analysis of Opioid-Seeking Behavior Through the Intravenous Self-Administration Reinstatement Model in Rats. Methods In Molecular Biology 2020, 2201: 231-245. PMID: 32975804, DOI: 10.1007/978-1-0716-0884-5_21.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAnalgesics, OpioidAnimalsBehavior ControlBehavior, AddictiveConditioning, OperantCuesDisease Models, AnimalDrug-Seeking BehaviorHeroinInfusions, IntravenousMaleOpioid-Related DisordersRatsRats, Sprague-DawleyRats, WistarReinforcement, PsychologyRewardSelf AdministrationSubstance-Related DisordersConceptsNeurobiological mechanismsAnimal model of relapseExtinction-reinstatement modelHeroin-seeking behaviorReinstatement animal modelRelapse-like behaviorModel of relapseRelapse to heroinVulnerability to relapseNose poke responsesPanel press responseNonhuman primatesReinstatement modelDrug seekingLever pressOperant respondingDrug abstinenceAddiction researchVulnerability factorsPress responseSubstance useOperant responseAnimal modelsIndividual slipsSelf-administered
2018
Old and new synthetic cannabinoids: lessons from animal models
Zanda M, Fattore L. Old and new synthetic cannabinoids: lessons from animal models. Drug Metabolism Reviews 2018, 50: 54-64. PMID: 29376443, DOI: 10.1080/03602532.2018.1430824.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCannabinoidsConditioning, OperantDisease Models, AnimalMarijuana AbuseModels, AnimalSelf AdministrationConceptsSynthetic cannabinoidsCannabinoid agonistsAnimal models of drug addictionConditioned place preference procedureModels of drug addictionPlace preference procedureBrain reward circuitsPositive reinforcing effectsDrug-induced behaviorsSynthetic cannabinoid agonistDelta-9-tetrahydrocannabinolReinstatement modelDrug discriminationReward circuitPreference procedureSelf-administrationAbuse liabilityPsychoactive componentAbuse potentialDrug addictionPsychiatric consequencesBehavioral studiesReinforcing effectsCannabinoidPsychoactive substances