2018
Sex and Feeding Status Differently Affect Natural Reward Seeking Behavior in Olfactory Bulbectomized Rats
Ruda-Kucerova J, Zanda M, Amchova P, Fratta W, Fattore L. Sex and Feeding Status Differently Affect Natural Reward Seeking Behavior in Olfactory Bulbectomized Rats. Frontiers In Behavioral Neuroscience 2018, 12: 255. PMID: 30425627, PMCID: PMC6218565, DOI: 10.3389/fnbeh.2018.00255.Peer-Reviewed Original ResearchSchedule of reinforcementPalatable food pelletsOBX ratsOBX lesionOperant respondingSelf-administrationFood pelletsNatural reward-seeking behaviorsIntravenous drug self-administrationSex differencesFood self-administrationDepressive-like phenotypeDrug self-administrationOperant self-administrationReward-seeking behaviorDrug-seeking behaviorRates of comorbidityPotential sex differencesFood restrictionOBX modelFood intakeOlfactory bulbectomyDrug-takingPalatable foodPsychiatric disorders
2014
Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms
Amchova P, Kucerova J, Giugliano V, Babinska Z, Zanda M, Scherma M, Dusek L, Fadda P, Micale V, Sulcova A, Fratta W, Fattore L. Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms. Frontiers In Pharmacology 2014, 5: 44. PMID: 24688470, PMCID: PMC3960502, DOI: 10.3389/fphar.2014.00044.Peer-Reviewed Original ResearchCB1 receptor agonist WIN55,212-2Model of depressionAgonist WIN55,212-2OBX ratsAcute pre-treatmentNucleus accumbensBulbectomized ratsSelf-administrationWIN55,212-2CGS 12066BIntravenous drug self-administration procedureRats self-administering methamphetamineDrug self-administration proceduresAnimal models of depressionSubstance use disorder comorbidityAssociated with drug consumptionBrain reward functionEnhanced self-administrationSelf-administer WINSerotonin 5HT1B receptor agonistsSham-operated ratsSelf-administer methamphetamineSelf-administration proceduresDepressive-like ratsDepressive-like state