ILD Publications

2022

Microenvironmental sensing by fibroblasts controls macrophage population size.Zhou X, Franklin RA, Adler M, Carter TS, Condiff E, Adams TS, Pope SD, Philip NH, Meizlish ML, Kaminski N, Medzhitov R. Proc Natl Acad Sci U S A. 2022 Aug 9; 2022 Aug 5. PMID: 35930670.
"Near Cure" treatment of severe acute EAE in MIF-1-deficient female and male mice with a bifunctional MHCII-derived molecular construct.Vandenbark AA, Meza-Romero R, Wiedrick J, Gerstner G, Seifert H, Kent G, Piechycna M, Benedek G, Bucala R, Offner H. Cell Immunol. 2022 Aug; 2022 Jun 11. PMID: 35738135.
PTX3 in Granuloma Formation and Sarcoidosis: Helping Macrophages Accept a "Complement".Ishikawa G, Herzog EL. Am J Respir Crit Care Med. 2022 Jul 12; 2022 Jul 12. PMID: 35820078.
Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation.Fernández-Castañeda A, Lu P, Geraghty AC, Song E, Lee MH, Wood J, O'Dea MR, Dutton S, Shamardani K, Nwangwu K, Mancusi R, Yalçın B, Taylor KR, Acosta-Alvarez L, Malacon K, Keough MB, Ni L, Woo PJ, Contreras-Esquivel D, Toland AMS, Gehlhausen JR, Klein J, Takahashi T, Silva J, Israelow B, Lucas C, Mao T, Peña-Hernández MA, Tabachnikova A, Homer RJ, Tabacof L, Tosto-Mancuso J, Breyman E, Kontorovich A, McCarthy D, Quezado M, Vogel H, Hefti MM, Perl DP, Liddelow S, Folkerth R, Putrino D, Nath A, Iwasaki A, Monje M. Cell. 2022 Jul 7; 2022 Jun 13. PMID: 35768006.
Arthritis & Rheumatology: "Mid-Term" Report.Solomon DH, Bucala R, Kaplan MJ, Nigrovic PA. Arthritis Rheumatol. 2022 Jul; 2022 May 6. PMID: 35358367.
Rationale and design of the SARCoidosis Outcomes in all respiratory Viral Infectious Diseases (SARCOVID) Study.Strykowski R, Patel DC, Neto MR, Hena KM, Gulati M, Maier LA, Patterson K. BMJ Open Respir Res. 2022 Jul. PMID: 35882424.
Development of an immunohistochemical assay for Siglec-15.Shafi S, Aung TN, Robbins C, Zugazagoitia J, Vathiotis I, Gavrielatou N, Yaghoobi V, Fernandez A, Niu S, Liu LN, Cusumano ZT, Leelatian N, Cole K, Wang H, Homer R, Herbst RS, Langermann S, Rimm DL. Lab Invest. 2022 Jul; 2022 Apr 22. PMID: 35459795.
Occupational and environmental exposures in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) study.Ryan SM, Mroz MM, Herzog EL, Ryu C, Fingerlin TE, Maier LA, Gulati M. Respir Med. 2022 Jun 30; 2022 Jun 30. PMID: 35932543.
Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2021.Ikonomou L, Magnusson M, Dries R, Herzog EL, Hynds R, Borok Z, Park JA, Skolasinski S, Burgess JK, Turner L, Mojarad SM, Mahoney JE, Lynch T, Lehmann M, Thannickal VJ, Hook JL, Vaughan AE, Hoffman ET, Weiss DJ, Ryan AL. Am J Physiol Lung Cell Mol Physiol. 2022 Jun 28; 2022 Jun 28. PMID: 35762622.
POU2F3 in SCLC: Clinicopathologic and Genomic Analysis With a Focus on Its Diagnostic Utility in Neuroendocrine-Low SCLC.Baine MK, Febres-Aldana CA, Chang JC, Jungbluth AA, Sethi S, Antonescu CR, Travis WD, Hsieh MS, Roh MS, Homer RJ, Ladanyi M, Egger JV, Lai WV, Rudin CM, Rekhtman N. J Thorac Oncol. 2022 Jun 24; 2022 Jun 24. PMID: 35760287.
Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency.Shin JJ, Par-Young J, Unlu S, McNamara A, Park HJ, Shin MS, Gee RJ, Doyle H, Afinogenova Y, Zidan E, Kwah J, Russo A, Mamula M, Hsu FI, Catanzaro J, Racke M, Bucala R, Wilen C, Kang I. J Clin Immunol. 2022 Jun 17; 2022 Jun 17. PMID: 35713752.
From COVID to fibrosis: lessons from single-cell analyses of the human lung.Justet A, Zhao AY, Kaminski N. Hum Genomics. 2022 Jun 13; 2022 Jun 13. PMID: 35698166.
Kasugamycin is a Novel Chitinase 1 Inhibitor with Strong Antifibrotic Effects on Pulmonary Fibrosis.Lee JH, Lee CM, Lee JH, Kim MO, Park JW, Kamle S, Akosman B, Herzog EL, Peng XY, Elias JA, Lee CG. Am J Respir Cell Mol Biol. 2022 Jun 9; 2022 Jun 9. PMID: 35679109.
CD38 Mediates Lung Fibrosis by Promoting Alveolar Epithelial Cell Aging.Cui H, Xie N, Banerjee S, Dey T, Liu RM, Antony VB, Sanders YY, Adams TS, Gomez JL, Thannickal VJ, Kaminski N, Liu G. Am J Respir Crit Care Med. 2022 Jun 6; 2022 Jun 6. PMID: 35687485.
Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis.Damsky W, Wang A, Kim DJ, Young BD, Singh K, Murphy MJ, Daccache J, Clark A, Ayasun R, Ryu C, McGeary MK, Odell ID, Fazzone-Chettiar R, Pucar D, Homer R, Gulati M, Miller EJ, Bosenberg M, Flavell RA, King B. Nat Commun. 2022 Jun 6; 2022 Jun 6. PMID: 35668129.
Bronchial epithelium epithelial-mesenchymal plasticity forms aberrant basaloid-like cells in vitro.Uthaya Kumar DB, Motakis E, Yurieva M, Kohar V, Martinek J, Wu TC, Khoury J, Grassmann J, Lu M, Palucka K, Kaminski N, Koff JL, Williams A. Am J Physiol Lung Cell Mol Physiol. 2022 Jun 1; 2022 Apr 19. PMID: 35438006.
BAL Transcriptomes Characterize Idiopathic Pulmonary Fibrosis Endotypes With Prognostic Impact.De Sadeleer LJ, Verleden SE, Schupp JC, McDonough JE, Goos T, Yserbyt J, Bargagli E, Rottoli P, Kaminski N, Prasse A, Wuyts WA. Chest. 2022 Jun; 2022 Jan 19. PMID: 35063449.
Standardizing the Reporting of Incidental, Non-Lung Cancer (Category S) Findings Identified on Lung Cancer Screening Low-Dose CT Imaging.Tanoue LT, Sather P, Cortopassi I, Dicks D, Curtis A, Michaud G, Bader A, Gange C Jr, Detterbeck F, Killam J. Chest. 2022 Jun; 2022 Jan 12. PMID: 35032477.
T Cell Response to Influenza Vaccination Remains Intact in Adults with Congenital Heart Disease Who Underwent Early Thymectomy.Leone DM, Park HJ, Unlu S, Gurvitz M, Kang I, Elder RW. Int J Cardiol Congenit Heart Dis. 2022 Jun; 2022 Mar 25. PMID: 35600131.
No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination.Lu-Culligan A, Tabachnikova A, Pérez-Then E, Tokuyama M, Lee HJ, Lucas C, Silva Monteiro V, Miric M, Brache V, Cochon L, Muenker MC, Mohanty S, Huang J, Kang I, Dela Cruz C, Farhadian S, Campbell M, Yildirim I, Shaw AC, Ma S, Vermund SH, Ko AI, Omer SB, Iwasaki A. PLoS Biol. 2022 May; 2022 May 24. PMID: 35609110.
Long-term evaluation of the safety and efficacy of recombinant human pentraxin-2 (rhPTX-2) in patients with idiopathic pulmonary fibrosis (IPF): an open-label extension study.Raghu G, Hamblin MJ, Brown AW, Golden JA, Ho LA, Wijsenbeek MS, Vasakova M, Pesci A, Antin-Ozerkis DE, Meyer KC, Kreuter M, Burgess T, Kamath N, Donaldson F, Richeldi L. Respir Res. 2022 May 21; 2022 May 21. PMID: 35597980.
NHLBI Report: Impact of Sex and Gender on Autoimmune Lung Disease, Opportunities for Future Research.Volkmann ER, Siegfried J, Lahm T, Ventetuolo CE, Mathai SC, Steen V, Herzog EL, Shansky R, Anguera MC, Danoff SK, Giles JT, Lee YC, Drake W, Maier LA, Lachowicz-Scroggins M, Park H, Banerjee K, Fessel J, Reineck L, Vuga L, Crouser E, Feghali-Bostwick C. Am J Respir Crit Care Med. 2022 May 13; 2022 May 13. PMID: 35549658.
Bladder Oxidative Stress and HMGB1 Release Contribute to PAR4-Mediated Bladder Pain in Mice.Ye S, Ma F, Mahmood DFD, Meyer-Siegler KL, Leng L, Bucala R, Vera PL. Front Syst Neurosci. 2022; 2022 May 13. PMID: 35645739.
Interleukin-17 Contributes to Chikungunya Virus-Induced Disease.Liu X, Poo YS, Alves JC, Almeida RP, Mostafavi H, Tang PCH, Bucala R, Teixeira MM, Taylor A, Zaid A, Mahalingam S. mBio. 2022 Apr 26; 2022 Mar 7. PMID: 35254128.
AHCC^®, a Standardized Extract of Cultured Lentinula Edodes Mycelia, Promotes the Anti-Tumor Effect of Dual Immune Checkpoint Blockade Effect in Murine Colon Cancer.Park HJ, Boo S, Park I, Shin MS, Takahashi T, Takanari J, Homma K, Kang I. Front Immunol. 2022; 2022 Apr 20. PMID: 35514996.
FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis.Preisendörfer S, Ishikawa Y, Hennen E, Winklmeier S, Schupp JC, Knüppel L, Fernandez IE, Binzenhöfer L, Flatley A, Juan-Guardela BM, Ruppert C, Guenther A, Frankenberger M, Hatz RA, Kneidinger N, Behr J, Feederle R, Schepers A, Hilgendorff A, Kaminski N, Meinl E, Bächinger HP, Eickelberg O, Staab-Weijnitz CA. Cells. 2022 Apr 14; 2022 Apr 14. PMID: 35456020.
Emerging insights in sarcoidosis: moving forward through reverse translational research.Liu A, Sharma L, Yan X, Dela Cruz CS, Herzog EL, Ryu C. Am J Physiol Lung Cell Mol Physiol. 2022 Apr 1; 2022 Feb 23. PMID: 35196896.
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells.Sumida TS, Dulberg S, Schupp JC, Lincoln MR, Stillwell HA, Axisa PP, Comi M, Unterman A, Kaminski N, Madi A, Kuchroo VK, Hafler DA. Nat Immunol. 2022 Apr; 2022 Mar 17. PMID: 35301508.
Managing COVID-19 going forward-the lessons from history.Bucala R, Friedland G, Snowden FM. QJM. 2022 Mar 9; 2022 Mar 9. PMID: 35262710.
Computation and visualization of cell-cell signaling topologies in single-cell systems data using Connectome.Raredon MSB, Yang J, Garritano J, Wang M, Kushnir D, Schupp JC, Adams TS, Greaney AM, Leiby KL, Kaminski N, Kluger Y, Levchenko A, Niklason LE. Sci Rep. 2022 Mar 9; 2022 Mar 9. PMID: 35264704.
Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis.Brereton CJ, Yao L, Davies ER, Zhou Y, Vukmirovic M, Bell JA, Wang S, Ridley RA, Dean LSN, Andriotis OG, Conforti F, Brewitz L, Mohammed S, Wallis T, Tavassoli A, Ewing RM, Alzetani A, Marshall BG, Fletcher SV, Thurner PJ, Fabre A, Kaminski N, Richeldi L, Bhaskar A, Schofield CJ, Loxham M, Davies DE, Wang Y, Jones MG. Elife. 2022 Feb 21; 2022 Feb 21. PMID: 35188460.
Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in patients with autoimmune hepatitis.Alrabadi LS, Dutton A, Rabiee A, Roberts SJ, Deng Y, Cusack L, Silveira MG, Ciarleglio M, Bucala R, Sinha R, Boyer JL, Assis DN. JHEP Rep. 2022 May; 2022 Feb 18. PMID: 35434588.
Defective Early B Cell Tolerance Checkpoints in Patients With Systemic Sclerosis Allow the Production of Self Antigen-Specific Clones.Glauzy S, Olson B, May CK, Parisi D, Massad C, Hansen JE, Ryu C, Herzog EL, Meffre E. Arthritis Rheumatol. 2022 Feb; 2021 Dec 16. PMID: 34279059.
An Acute Exacerbation of Idiopathic Pulmonary Fibrosis After BNT162b2 mRNA COVID-19 Vaccination: A Case Report.Ghincea A, Ryu C, Herzog EL. Chest. 2022 Feb. PMID: 35131075.
Correction to: COVID‑19 ARDS: a review of imaging features and overview of mechanical ventilation and its complications.Gosangi B, Rubinowitz AN, Irugu D, Gange C, Bader A, Cortopassi I. Emerg Radiol. 2022 Feb. PMID: 34741693.
COVID-19 ARDS: a review of imaging features and overview of mechanical ventilation and its complications.Gosangi B, Rubinowitz AN, Irugu D, Gange C, Bader A, Cortopassi I. Emerg Radiol. 2022 Feb; 2021 Oct 26. PMID: 34698956.
Low IgG trough and lymphocyte subset counts are associated with hospitalization for COVID-19 in patients with primary antibody deficiency.Kuster JK, Unlu S, Makin TA, Par-Young J, Simonov M, Shafi S, Balanda M, Randolph C, Steele R, Hsu FI, Price C, Kohli-Pamnani A, Borish L, Lawrence MG, Kang I, Shin JJ. J Allergy Clin Immunol Pract. 2022 Feb; 2021 Dec 18. PMID: 34929372.
Correction to: Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort.Todd JL, Neely ML, Overton R, Mulder H, Roman J, Lasky JA, de Andrade JA, Gulati M, Huang H, Leonard TB, Hesslinger C, Noth I, Belperio JA, Flaherty KR, Palmer SM. Lung. 2022 Feb. PMID: 35166906.
Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort.Todd JL, Neely ML, Overton R, Mulder H, Roman J, Lasky JA, de Andrade JA, Gulati M, Huang H, Leonard TB, Hesslinger C, Noth I, Belperio JA, Flaherty KR, Palmer SM. Lung. 2022 Feb; 2022 Jan 23. PMID: 35066606.
CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis.Chen L, Yin Z, Qin X, Zhu X, Chen X, Ding G, Sun D, Wu NN, Fei J, Bi Y, Zhang J, Bucala R, Ren J, Zheng Q. Pharmacol Res. 2022 Feb; 2022 Jan 13. PMID: 35033649.
Targeting fibrocytes in autoimmunity.Bucala RJ. Proc Natl Acad Sci U S A. 2022 Feb 1. PMID: 35086933.
Macrophage migration inhibitory factor regulates specific innate immune sensor responses in gingival epithelial cells.Kantrong N, Chang AM, Bamashmous S, Hajjar AM, Bucala RJ, Darveau RP. J Periodontol. 2022 Jan 31; 2022 Jan 31. PMID: 35100435.
Characterization of the COPD alveolar niche using single-cell RNA sequencing.Sauler M, McDonough JE, Adams TS, Kothapalli N, Barnthaler T, Werder RB, Schupp JC, Nouws J, Robertson MJ, Coarfa C, Yang T, Chioccioli M, Omote N, Cosme C Jr, Poli S, Ayaub EA, Chu SG, Jensen KH, Gomez JL, Britto CJ, Raredon MSB, Niklason LE, Wilson AA, Timshel PN, Kaminski N, Rosas IO. Nat Commun. 2022 Jan 25; 2022 Jan 25. PMID: 35078977.
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C Jr, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K, Niklason LE, Ko AI, Montgomery RR, Farhadian SF, Iwasaki A, Shaw AC, van Dijk D, Zhao H, Kleinstein SH, Hafler DA, Kaminski N, Dela Cruz CS. Nat Commun. 2022 Jan 21; 2022 Jan 21. PMID: 35064122.
Lung Microenvironments and Disease Progression in Fibrotic Hypersensitivity Pneumonitis.De Sadeleer LJ, McDonough JE, Schupp JC, Yan X, Vanstapel A, Van Herck A, Everaerts S, Geudens V, Sacreas A, Goos T, Aelbrecht C, Nawrot TS, Martens DS, Schols D, Claes S, Verschakelen JA, Verbeken EK, Ackermann M, Decottignies A, Mahieu M, Hackett TL, Hogg JC, Vanaudenaerde BM, Verleden SE, Kaminski N, Wuyts WA. Am J Respir Crit Care Med. 2022 Jan 1. PMID: 34724391.
Global Rheumatology Research: Frontiers, Challenges, and Opportunities.Bilsborrow JB, Peláez-Ballestas I, Pons-Estel B, Scott C, Tian X, Alarcon GS, Bucala R, Lewandowski LB, Hsieh E. Arthritis Rheumatol. 2022 Jan; 2021 Dec 8. PMID: 34535973.
Persistent Exertional Intolerance After COVID-19: Insights From Invasive Cardiopulmonary Exercise Testing.Singh I, Joseph P, Heerdt PM, Cullinan M, Lutchmansingh DD, Gulati M, Possick JD, Systrom DM, Waxman AB. Chest. 2022 Jan; 2021 Aug 11. PMID: 34389297.

2021

Canonical (CD74/CD44) and Non-Canonical (CXCR2, 4 and 7) MIF Receptors Are Differentially Expressed in Rheumatoid Arthritis Patients Evaluated by DAS28-ESR.Sánchez-Zuno GA, Bucala R, Hernández-Bello J, Román-Fernández IV, García-Chagollán M, Nicoletti F, Matuz-Flores MG, García-Arellano S, Esparza-Michel JA, Cerpa-Cruz S, Pérez-Guerrero EE, Muñoz-Valle JF. J Clin Med. 2021 Dec 27; 2021 Dec 27. PMID: 35011861.
Fibroblasts positive for meflin have anti-fibrotic properties in pulmonary fibrosis.Nakahara Y, Hashimoto N, Sakamoto K, Enomoto A, Adams TS, Yokoi T, Omote N, Poli S, Ando A, Wakahara K, Suzuki A, Inoue M, Hara A, Mizutani Y, Imaizumi K, Kawabe T, Rosas IO, Takahashi M, Kaminski N, Hasegawa Y. Eur Respir J. 2021 Dec; 2021 Dec 23. PMID: 34049947.
Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis.Chandran RR, Xie Y, Gallardo-Vara E, Adams T, Garcia-Milian R, Kabir I, Sheikh AQ, Kaminski N, Martin KA, Herzog EL, Greif DM. Nat Commun. 2021 Dec 10; 2021 Dec 10. PMID: 34893592.
Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis.Vukmirovic M, Yan X, Gibson KF, Gulati M, Schupp JC, DeIuliis G, Adams TS, Hu B, Mihaljinec A, Woolard TN, Lynn H, Emeagwali N, Herzog EL, Chen ES, Morris A, Leader JK, Zhang Y, Garcia JGN, Maier LA, Collman RG, Drake WP, Becich MJ, Hochheiser H, Wisniewski SR, Benos PV, Moller DR, Prasse A, Koth LL, Kaminski N. Eur Respir J. 2021 Dec; 2021 Dec 2. PMID: 34083402.
Brief report: Enhanced DRα1-mMOG-35-55 treatment of severe EAE in MIF-1-deficient male mice.Vandenbark AA, Meza-Romero R, Wiedrick J, Gerstner G, Headrick A, Kent G, Seifert H, Benedek G, Bucala R, Offner H. Cell Immunol. 2021 Dec; 2021 Sep 11. PMID: 34607646.
Suppression of Plasmodium MIF-CD74 signaling protects against severe malaria.Baeza Garcia A, Siu E, Du X, Leng L, Franke-Fayard B, Janse CJ, Howland SW, Rénia L, Lolis E, Bucala R. FASEB J. 2021 Dec. PMID: 34719814.
MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model.Tilstam PV, Schulte W, Holowka T, Kim BS, Nouws J, Sauler M, Piecychna M, Pantouris G, Lolis E, Leng L, Bernhagen J, Fingerle-Rowson G, Bucala R. J Clin Invest. 2021 Dec 1. PMID: 34850744.
A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds.Yuan Y, Leiby KL, Greaney AM, Raredon MSB, Qian H, Schupp JC, Engler AJ, Baevova P, Adams TS, Kural MH, Wang J, Obata T, Yoder MC, Kaminski N, Niklason LE. Front Bioeng Biotechnol. 2021; 2021 Nov 19. PMID: 34869270.
Case Report: Bullous Lung Disease Following COVID-19.Pednekar P, Amoah K, Homer R, Ryu C, Lutchmansingh DD. Front Med (Lausanne). 2021; 2021 Nov 17. PMID: 34869488.
Machine learning implicates the IL-18 signaling axis in severe asthma.Camiolo MJ, Zhou X, Wei Q, Trejo Bittar HE, Kaminski N, Ray A, Wenzel SE. JCI Insight. 2021 Nov 8; 2021 Nov 8. PMID: 34591794.
Macrophage migration inhibitory factor exerts pro-proliferative and anti-apoptotic effects via CD74 in murine hepatocellular carcinoma.Wirtz TH, Saal A, Bergmann I, Fischer P, Heinrichs D, Brandt EF, Koenen MT, Djudjaj S, Schneider KM, Boor P, Bucala R, Weiskirchen R, Bernhagen J, Trautwein C, Berres ML. Br J Pharmacol. 2021 Nov; 2021 Aug 24. PMID: 34250589.
A distinct association of inflammatory molecules with outcomes of COVID-19 in younger versus older adults.Shin JJ, Jeon S, Unlu S, Par-Young J, Shin MS, Kuster JK, Afinogenova Y, Kang Y, Simonov M, Buller G, Bucala R, Kang I. Clin Immunol. 2021 Nov; 2021 Sep 22. PMID: 34560283.
Elevated murine HB-EGF confers sensitivity to diphtheria toxin in EGFR-mutant lung adenocarcinoma.Robles-Oteiza C, Ayeni D, Levy S, Homer RJ, Kaech SM, Politi K. Dis Model Mech. 2021 Nov 1; 2021 Nov 15. PMID: 34494649.
A Markov random field model for network-based differential expression analysis of single-cell RNA-seq data.Li H, Zhu B, Xu Z, Adams T, Kaminski N, Zhao H. BMC Bioinformatics. 2021 Oct 26; 2021 Oct 26. PMID: 34702190.
Macrophage migration inhibitory factor drives pathology in a mouse model of spondyloarthritis and is associated with human disease.Nakamura A, Zeng F, Nakamura S, Reid KT, Gracey E, Lim M, Leng L, Jo S, Park YS, Kusuda M, Machhar R, Boroojeni SF, Wu B, Rossomacha E, Kim TH, Ciccia F, Rockel JS, Kapoor M, Inman RD, Jurisica I, Crome SQ, Bucala R, Haroon N. Sci Transl Med. 2021 Oct 20; 2021 Oct 20. PMID: 34669443.
ICBP90 Regulates MIF Expression, Glucocorticoid Sensitivity, and Apoptosis at the MIF Immune Susceptibility Locus.Yao J, Leng L, Fu W, Li J, Bronner C, Bucala R. Arthritis Rheumatol. 2021 Oct; 2021 Sep 3. PMID: 33844457.
Correction to: Abnormalities of Aspiration and Swallowing Function in Survivors of Acute Respiratory Failure.Langmore SE, Krisciunas GP, Warner H, White SD, Dvorkin D, Fink D, McNally E, Scheel R, Higgins C, Levitt JE, McKeehan J, Deane S, Siner JM, Vojnik R, Moss M. Dysphagia. 2021 Oct. PMID: 33635374.
Abnormalities of Aspiration and Swallowing Function in Survivors of Acute Respiratory Failure.Langmore SE, Krisciunas GP, Warner H, White SD, Dvorkin D, Fink D, McNally E, Scheel R, Higgins C, Levitt JE, McKeehan J, Deane S, Siner JM, Vojnik R, Moss M. Dysphagia. 2021 Oct; 2020 Nov 6. PMID: 33156398.
Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic Data.Manning EP, Ramachandra AB, Schupp JC, Cavinato C, Raredon MSB, Bärnthaler T, Cosme C Jr, Singh I, Tellides G, Kaminski N, Humphrey JD. Front Physiol. 2021; 2021 Sep 14. PMID: 34594238.
Intravesical CD74 and CXCR4, macrophage migration inhibitory factor (MIF) receptors, mediate bladder pain.Ye S, Ma F, Mahmood DFD, Meyer-Siegler KL, Menard RE, Hunt DE, Leng L, Bucala R, Vera PL. PLoS One. 2021; 2021 Aug 23. PMID: 34424927.
Integrated computational and experimental pipeline for quantifying local cell-matrix interactions.Xiao H, Nguyen RY, LaRanger R, Herzog EL, Mak M. Sci Rep. 2021 Aug 12; 2021 Aug 12. PMID: 34385554.
Evolving Perspectives on Innate Immune Mechanisms of IPF.Ishikawa G, Liu A, Herzog EL. Front Mol Biosci. 2021; 2021 Aug 9. PMID: 34434962.
Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets.Reichmann MT, Tezera LB, Vallejo AF, Vukmirovic M, Xiao R, Reynolds J, Jogai S, Wilson S, Marshall B, Jones MG, Leslie A, D'Armiento JM, Kaminski N, Polak ME, Elkington P. J Clin Invest. 2021 Aug 2. PMID: 34128839.
Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung.Schupp JC, Adams TS, Cosme C Jr, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe'er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Circulation. 2021 Jul 27; 2021 May 25. PMID: 34030460.
Fibroblasts: Origins, definitions, and functions in health and disease.Plikus MV, Wang X, Sinha S, Forte E, Thompson SM, Herzog EL, Driskell RR, Rosenthal N, Biernaskie J, Horsley V. Cell. 2021 Jul 22. PMID: 34297930.
Blood Transcriptomics Predicts Progression of Pulmonary Fibrosis and Associated Natural Killer Cells.Huang Y, Oldham JM, Ma SF, Unterman A, Liao SY, Barros AJ, Bonham CA, Kim JS, Vij R, Adegunsoye A, Strek ME, Molyneaux PL, Maher TM, Herazo-Maya JD, Kaminski N, Moore BB, Martinez FJ, Noth I. Am J Respir Crit Care Med. 2021 Jul 15. PMID: 33689671.
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity.Bui LT, Winters NI, Chung MI, Joseph C, Gutierrez AJ, Habermann AC, Adams TS, Schupp JC, Poli S, Peter LM, Taylor CJ, Blackburn JB, Richmond BW, Nicholson AG, Rassl D, Wallace WA, Rosas IO, Jenkins RG, Kaminski N, Kropski JA, Banovich NE. Nat Commun. 2021 Jul 14; 2021 Jul 14. PMID: 34262047.
Antibodies against human endogenous retrovirus K102 envelope activate neutrophils in systemic lupus erythematosus.Tokuyama M, Gunn BM, Venkataraman A, Kong Y, Kang I, Rakib T, Townsend MJ, Costenbader KH, Alter G, Iwasaki A. J Exp Med. 2021 Jul 5; 2021 May 21. PMID: 34019642.
Nucleotide-binding domain and leucine-rich-repeat-containing protein X1 deficiency induces nicotinamide adenine dinucleotide decline, mechanistic target of rapamycin activation, and cellular senescence and accelerates aging lung-like changes.Shin HJ, Kim SH, Park HJ, Shin MS, Kang I, Kang MJ. Aging Cell. 2021 Jul; 2021 Jun 4. PMID: 34087956.
Genetic Determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo.Foggetti G, Li C, Cai H, Hellyer JA, Lin WY, Ayeni D, Hastings K, Choi J, Wurtz A, Andrejka L, Maghini DG, Rashleigh N, Levy S, Homer R, Gettinger SN, Diehn M, Wakelee HA, Petrov DA, Winslow MM, Politi K. Cancer Discov. 2021 Jul; 2021 Mar 11. PMID: 33707235.
Effectiveness of Thermal Ablation and Stereotactic Radiotherapy Based on Stage I Lung Cancer Histology.Uhlig J, Mehta S, Case MD, Dhanasopon A, Blasberg J, Homer RJ, Solomon SB, Kim HS. J Vasc Interv Radiol. 2021 Jul; 2021 Mar 31. PMID: 33811997.
Effector Memory CD8⁺ and CD4⁺ T Cell Immunity Associated with Metabolic Syndrome in Obese Children.Yang DH, Lee H, Lee N, Shin MS, Kang I, Kang KS. Pediatr Gastroenterol Hepatol Nutr. 2021 Jul; 2021 Jul 5. PMID: 34316472.
Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19.Hoehn KB, Ramanathan P, Unterman A, Sumida TS, Asashima H, Hafler DA, Kaminski N, Dela Cruz CS, Sealfon SC, Bukreyev A, Kleinstein SH. J Immunol. 2021 Jun 15; 2021 May 28. PMID: 34049971.
Role of MIF in coordinated expression of hepatic chemokines in patients with alcohol-associated hepatitis.Poulsen KL, Fan X, Kibler CD, Huang E, Wu X, McMullen MR, Leng L, Bucala R, Ventura-Cots M, Argemi J, Bataller R, Nagy LE. JCI Insight. 2021 Jun 8; 2021 Jun 8. PMID: 33945507.
Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells.Hafler D, Sumida T, Dulberg S, Schupp J, Stillwell H, Axisa PP, Comi M, Lincoln M, Unterman A, Kaminski N, Madi A, Kuchroo V. Res Sq. 2021 Jun 8; 2021 Jun 8. PMID: 34127967.
Elevated IL-15 concentrations in the sarcoidosis lung are independent of granuloma burden and disease phenotypes.Minasyan M, Sharma L, Pivarnik T, Liu W, Adams T, Bermejo S, Peng X, Liu A, Ishikawa G, Perry C, Kaminski N, Gulati M, Herzog EL, Dela Cruz CS, Ryu C. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 1; 2021 Apr 14. PMID: 33851886.
PINK1 mediates the protective effects of thyroid hormone T3 in hyperoxia-induced lung injury.Zhang Y, Yu G, Kaminski N, Lee PJ. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 1; 2021 Apr 14. PMID: 33851544.
Reliability of histopathologic diagnosis of fibrotic interstitial lung disease: an international collaborative standardization project.Camp R, Smith ML, Larsen BT, Roden AC, Farver C, Moreira AL, Attanoos R, Pillappa R, Sansano I, Fabro AT, Homer RJ. BMC Pulm Med. 2021 Jun 1; 2021 Jun 1. PMID: 34074264.
Molecular Markers and the Promise of Precision Medicine for Interstitial Lung Disease.Newton CA, Herzog EL. Clin Chest Med. 2021 Jun. PMID: 34024410.
Cathepsin B promotes collagen biosynthesis, which drives bronchiolitis obliterans syndrome.Morrone C, Smirnova NF, Jeridi A, Kneidinger N, Hollauer C, Schupp JC, Kaminski N, Jenne D, Eickelberg O, Yildirim AÖ. Eur Respir J. 2021 May; 2021 May 13. PMID: 33303550.
Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children.Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. Immunity. 2021 May 11; 2021 Apr 13. PMID: 33891889.
17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex.Harrison DE, Strong R, Reifsnyder P, Kumar N, Fernandez E, Flurkey K, Javors MA, Lopez-Cruzan M, Macchiarini F, Nelson JF, Markewych A, Bitto A, Sindler AL, Cortopassi G, Kavanagh K, Leng L, Bucala R, Rosenthal N, Salmon A, Stearns TM, Bogue M, Miller RA. Aging Cell. 2021 May; 2021 Mar 31. PMID: 33788371.
The Reply.Bader AS, Rubinowitz AN, Gange CP Jr, Bader EM, Cortopassi IO. Am J Med. 2021 May. PMID: 33962714.
Initial Evaluation of Rapid, Direct-to-Digital Prostate Biopsy Pathology.Torres R, Olson E, Homer R, Martin DT, Levene MJ, Perincheri S, Sprenkle PC, Humphrey PA. Arch Pathol Lab Med. 2021 May 1. PMID: 32991670.
An 84-Year-Old Physician With Progressive Dyspnea and Bilateral Upper Lobe Opacities.Harris ZM, Antin-Ozerkis D. Chest. 2021 May. PMID: 33965157.
Response.Price CC, Altice FL, Azar MM, McManus D, Gleeson SE, Britto CJ, Azmy V, Kaman K, Davis M, Chupp G, Bucala R, Kaminski N, Topal JE, Dela Cruz C, Malinis M. Chest. 2021 May. PMID: 33965143.
Infectious Complications Predict Premature CD8⁺ T-cell Senescence in CD40 Ligand-Deficient Patients.Shin JJ, Catanzaro J, Yonkof JR, Delmonte O, Sacco K, Shin MS, Reddy S, Whittington PJ, Soffer G, Mustillo PJ, Sullivan KE, Notarangelo LD, Abraham RS, Romberg N, Kang I. J Clin Immunol. 2021 May; 2021 Jan 26. PMID: 33495902.
Non-steroidal treatment of cardiac sarcoidosis: A systematic review.Gallegos C, Oikonomou EK, Grimshaw A, Gulati M, Young BD, Miller EJ. Int J Cardiol Heart Vasc. 2021 Jun; 2021 Apr 29. PMID: 33997256.
Mitochondrial antiviral signaling protein is crucial for the development of pulmonary fibrosis.Kim SH, Lee JY, Yoon CM, Shin HJ, Lee SW, Rosas I, Herzog E, Dela Cruz CS, Kaminski N, Kang MJ. Eur Respir J. 2021 Apr; 2021 Apr 15. PMID: 33093124.
Intermediate-dose anticoagulation, aspirin, and in-hospital mortality in COVID-19: A propensity score-matched analysis.Meizlish ML, Goshua G, Liu Y, Fine R, Amin K, Chang E, DeFilippo N, Keating C, Liu Y, Mankbadi M, McManus D, Wang SY, Price C, Bona RD, Ochoa Chaar CI, Chun HJ, Pine AB, Rinder HM, Siner JM, Neuberg DS, Owusu KA, Lee AI. Am J Hematol. 2021 Apr 1; 2021 Feb 22. PMID: 33476420.
COVID-19 as an occupational disease.Carlsten C, Gulati M, Hines S, Rose C, Scott K, Tarlo SM, Torén K, Sood A, de la Hoz RE. Am J Ind Med. 2021 Apr; 2021 Jan 24. PMID: 33491195.
Elevated plasma level of Pentraxin 3 is associated with emphysema and mortality in smokers.Zhang Y, Tedrow J, Nouraie M, Li X, Chandra D, Bon J, Kass DJ, Fuhrman CR, Leader JK, Duncan SR, Kaminski N, Sciurba FC. Thorax. 2021 Apr; 2021 Jan 21. PMID: 33479043.
Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection.McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ Jr, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. PLoS One. 2021; 2021 Mar 31. PMID: 33788846.