A small molecule macrophage migration inhibitory factor agonist ameliorates age-related myocardial intolerance to ischemia-reperfusion insults via metabolic regulation
Wang H, Slotabec L, Didik S, Li Z, Leng L, Zhao B, Bucala R, Li J. A small molecule macrophage migration inhibitory factor agonist ameliorates age-related myocardial intolerance to ischemia-reperfusion insults via metabolic regulation. Metabolism 2024, 153: 155792. PMID: 38232801, PMCID: PMC10932879, DOI: 10.1016/j.metabol.2024.155792.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorActivating AMP-activated protein kinaseI/R stressAging heartMacrophage migration inhibitory factor expressionCardiac metabolic profileReactive oxygen speciesIschemia-reperfusion insultIschemia-reperfusion (I/RAMP-activated protein kinaseMIF signalingMigration inhibitory factorDecreased myocardial infarct sizeAccumulation of reactive oxygen speciesMyocardial infarct sizeSystolic functionInnate cytokinesPharmacological augmentationSenescent heartsAged myocardiumSenescent myocardiumAge-related reductionIschemia-reperfusionI/R injuryMetabolic profile