2020
Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology
Wisnewski AV, Liu J, Redlich CA. Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology. American Journal Of Respiratory Cell And Molecular Biology 2020, 0: 25-35. PMID: 32101465, PMCID: PMC7328250, DOI: 10.1165/rcmb.2019-0400oc.Peer-Reviewed Original ResearchConceptsRespiratory tract exposureAirway eosinophiliaMonocytes/macrophagesMouse modelGene expressionGene transcriptsBiological pathwaysAsthma pathologyUpregulated gene transcriptsIgE-independent mechanismsLung gene expressionLung tissue gene expressionCause of asthmaBALB/cTransgenic B cellsTissue gene expressionExpression changesDiisocyanate asthmaSensitized workersAsthma pathogenesisAirway fluidDeficient miceMRNA microarrayEosinophiliaB cells
2003
Differential roles for CD4 and CD8 T cells after diisocyanate sensitization: Genetic control of TH2-induced lung inflammation
Herrick CA, Das J, Xu L, Wisnewski AV, Redlich CA, Bottomly K. Differential roles for CD4 and CD8 T cells after diisocyanate sensitization: Genetic control of TH2-induced lung inflammation. Journal Of Allergy And Clinical Immunology 2003, 111: 1087-1094. PMID: 12743574, DOI: 10.1067/mai.2003.1413.Peer-Reviewed Original ResearchConceptsContact hypersensitivityT cellsAirway eosinophiliaAirway inflammationBALB/c miceDiisocyanate-induced asthmaCD8 T cellsLung inflammatory responseMajor effector cellsIL-13 productionMeans of inhalationNovel mouse modelEpicutaneous exposureAtopic asthmaLung inflammationMucus hypersecretionOccupational asthmaEpicutaneous sensitizationEffector cellsCytokine productionC miceIL-5Serum antibodiesInflammatory responseC57BL/10 mice
2002
Mouse Models of Diisocyanate Asthma
Redlich CA, Wisnewski AV, Gordon T. Mouse Models of Diisocyanate Asthma. American Journal Of Respiratory Cell And Molecular Biology 2002, 27: 385-390. PMID: 12356570, DOI: 10.1165/rcmb.f249.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsA novel mouse model of diisocyanate-induced asthma showing allergic-type inflammation in the lung after inhaled antigen challenge
Herrick CA, Xu L, Wisnewski AV, Das J, Redlich CA, Bottomly K. A novel mouse model of diisocyanate-induced asthma showing allergic-type inflammation in the lung after inhaled antigen challenge. Journal Of Allergy And Clinical Immunology 2002, 109: 873-878. PMID: 11994714, DOI: 10.1067/mai.2002.123533.Peer-Reviewed Original ResearchConceptsDiisocyanate-induced asthmaNovel mouse modelLung inflammationMouse modelAirway eosinophiliaAntigen challengeHuman asthmaAntigen-induced lung inflammationBALB/c miceAllergic-type inflammationLung inflammatory cellsCytokine-deficient miceVigorous inflammatory responsePrevious mouse modelsAtopic asthmaMucus hypersecretionOccupational asthmaContact hypersensitivityInflammatory cellsC miceInflammatory responseType cytokinesIFN-gammaAsthmaHuman diseases
1996
IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury.
Redlich C, Gao X, Rockwell S, Kelley M, Elias J. IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury. The Journal Of Immunology 1996, 157: 1705-10. PMID: 8759759, DOI: 10.4049/jimmunol.157.4.1705.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBronchoalveolar Lavage FluidCell LineGene Expression RegulationGene Expression Regulation, NeoplasticInjections, SubcutaneousInterleukin-11Lung NeoplasmsMacrophages, AlveolarMiceMice, Inbred BALB CNeoplasm ProteinsNeoplastic Stem CellsRadiation Injuries, ExperimentalRecombinant ProteinsRNA, MessengerRNA, NeoplasmSpecific Pathogen-Free OrganismsThoracic InjuriesTumor Necrosis Factor-alphaConceptsThoracic irradiationThoracic injuriesControl miceTNF protein productionTNF productionVehicle-treated control miceNormal thoracic structuresPulmonary metastatic tumorsEMT6 tumor cellsTNF mRNA expressionDose of radiationLung metastasesInhibits LPSMetastatic tumorsNormal lungRadioprotective effectMRNA expressionIL-11Enhances SurvivalTumor cellsObserved protectionSignificant radioprotectionTNF mRNAThoracic structuresStudy interval