2020
Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology
Wisnewski AV, Liu J, Redlich CA. Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology. American Journal Of Respiratory Cell And Molecular Biology 2020, 0: 25-35. PMID: 32101465, PMCID: PMC7328250, DOI: 10.1165/rcmb.2019-0400oc.Peer-Reviewed Original ResearchConceptsRespiratory tract exposureAirway eosinophiliaMonocytes/macrophagesMouse modelGene expressionGene transcriptsBiological pathwaysAsthma pathologyUpregulated gene transcriptsIgE-independent mechanismsLung gene expressionLung tissue gene expressionCause of asthmaBALB/cTransgenic B cellsTissue gene expressionExpression changesDiisocyanate asthmaSensitized workersAsthma pathogenesisAirway fluidDeficient miceMRNA microarrayEosinophiliaB cells
2007
Cost‐Effectiveness of Various Diagnostic Approaches for Occupational Asthma
Kennedy WA, Girard F, Chaboillez S, Cartier A, Côté J, Hargreave F, Labrecque M, Malo JL, Tarlo SM, Redlich CA, Lemière C. Cost‐Effectiveness of Various Diagnostic Approaches for Occupational Asthma. Canadian Respiratory Journal 2007, 14: 276-280. PMID: 17703242, PMCID: PMC2676393, DOI: 10.1155/2007/206519.Peer-Reviewed Original ResearchConceptsSpecific inhalation challengeOccupational asthmaSputum testingProbabilistic sensitivity analysesPEF monitoringDiagnosis of OASputum cell countsProportion of eosinophilsExpiratory flow monitoringAdditional correct diagnosisBase-case analysisInhalation challengeClinical outcomesOA patientsTreeAge ProClinical dataSerial measurementsCorrect diagnosisPatientsCanadian hospitalsCell countDiagnostic approachGold standardDiagnosisCost-effective alternative
2002
A novel mouse model of diisocyanate-induced asthma showing allergic-type inflammation in the lung after inhaled antigen challenge
Herrick CA, Xu L, Wisnewski AV, Das J, Redlich CA, Bottomly K. A novel mouse model of diisocyanate-induced asthma showing allergic-type inflammation in the lung after inhaled antigen challenge. Journal Of Allergy And Clinical Immunology 2002, 109: 873-878. PMID: 11994714, DOI: 10.1067/mai.2002.123533.Peer-Reviewed Original ResearchConceptsDiisocyanate-induced asthmaNovel mouse modelLung inflammationMouse modelAirway eosinophiliaAntigen challengeHuman asthmaAntigen-induced lung inflammationBALB/c miceAllergic-type inflammationLung inflammatory cellsCytokine-deficient miceVigorous inflammatory responsePrevious mouse modelsAtopic asthmaMucus hypersecretionOccupational asthmaContact hypersensitivityInflammatory cellsC miceInflammatory responseType cytokinesIFN-gammaAsthmaHuman diseases
1998
Vitamin A Inhibits Radiation-Induced Pneumonitis in Rats 1 , 2
Redlich C, Rockwell S, Chung J, Sikora A, Kelley M, Mayne S. Vitamin A Inhibits Radiation-Induced Pneumonitis in Rats 1 , 2. Journal Of Nutrition 1998, 128: 1661-1664. PMID: 9772133, DOI: 10.1093/jn/128.10.1661.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBronchoalveolar Lavage FluidDietDose-Response Relationship, DrugLungMaleNutritional StatusRadiation PneumonitisRatsVitamin AVitamin A DeficiencyVitamin EConceptsRadiation-induced lung injuryVitamin ALung injuryLung inflammationRadiation-induced lung inflammationLung retinol levelsSupplemental vitamin AAltered vitaminThoracic radiationThoracic radiotherapyBronchoalveolar lavagePrescribed dietRetinol levelsDeficient groupDeficient dietTotal doseY ratsRadioprotective agentsRats 1RatsWhole thoraxHost susceptibilityDietInflammationInjuryEffect of supplementation with beta-carotene and vitamin A on lung nutrient levels.
Redlich CA, Blaner WS, Van Bennekum AM, Chung JS, Clever SL, Holm CT, Cullen MR. Effect of supplementation with beta-carotene and vitamin A on lung nutrient levels. Cancer Epidemiology Biomarkers & Prevention 1998, 7: 211-4. PMID: 9521435.Peer-Reviewed Original ResearchConceptsActive armRetinol levelsLung tissueExcess lung cancer mortalityLung cancer chemoprevention trialsLung retinol levelsRetinol Efficacy TrialLung tissue levelsLung cancer mortalityCancer chemoprevention trialsEffect of supplementationLung retinolChemoprevention trialsCancer mortalitySurgical controlEfficacy trialsCell levelVitamin ARetinyl palmitateSame interventionTissue levelsBiomarker studiesSupplementationInterventionTrials
1996
Characterization of carotenoid, vitamin A, and alpha-tocopheral levels in human lung tissue and pulmonary macrophages.
Redlich CA, Grauer JN, Van Bennekum AM, Clever SL, Ponn RB, Blaner WS. Characterization of carotenoid, vitamin A, and alpha-tocopheral levels in human lung tissue and pulmonary macrophages. American Journal Of Respiratory And Critical Care Medicine 1996, 154: 1436-1443. PMID: 8912761, DOI: 10.1164/ajrccm.154.5.8912761.Peer-Reviewed Original ResearchMeSH KeywordsAgedBeta CaroteneBronchoalveolar Lavage FluidChromatography, High Pressure LiquidDietFemaleHumansLungLung NeoplasmsMacrophages, AlveolarMaleMiddle AgedVitamin AVitamin EConceptsLung tissue levelsHuman lung tissueBAL cellsLung tissueAlpha-tocopherolTissue levelsSerum levelsHigh-pressure liquid chromatographyBronchoalveolar lavage cellsOpen lung surgeryFresh lung tissueImportant protective effectDietary questionnaireLung surgeryLavage cellsProtective effectPulmonary macrophagesReverse-phase high-pressure liquid chromatographyVitamin AHuman lungDietary levelsPotential markerRetinolSerumPatientsIL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury.
Redlich C, Gao X, Rockwell S, Kelley M, Elias J. IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury. The Journal Of Immunology 1996, 157: 1705-10. PMID: 8759759, DOI: 10.4049/jimmunol.157.4.1705.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBronchoalveolar Lavage FluidCell LineGene Expression RegulationGene Expression Regulation, NeoplasticInjections, SubcutaneousInterleukin-11Lung NeoplasmsMacrophages, AlveolarMiceMice, Inbred BALB CNeoplasm ProteinsNeoplastic Stem CellsRadiation Injuries, ExperimentalRecombinant ProteinsRNA, MessengerRNA, NeoplasmSpecific Pathogen-Free OrganismsThoracic InjuriesTumor Necrosis Factor-alphaConceptsThoracic irradiationThoracic injuriesControl miceTNF protein productionTNF productionVehicle-treated control miceNormal thoracic structuresPulmonary metastatic tumorsEMT6 tumor cellsTNF mRNA expressionDose of radiationLung metastasesInhibits LPSMetastatic tumorsNormal lungRadioprotective effectMRNA expressionIL-11Enhances SurvivalTumor cellsObserved protectionSignificant radioprotectionTNF mRNAThoracic structuresStudy interval