2024
NCCN Guidelines® Insights: Survivorship, Version 2.2024.
Sanft T, Day A, Goldman M, Ansbaugh S, Armenian S, Baker K, Ballinger T, Demark-Wahnefried W, Fairman N, Feliciano J, Flores T, Friedman D, Gabel N, Hill-Kayser C, Koura D, Lee K, Lee N, McDonough A, Melisko M, Mooney K, Moore H, Moryl N, Neuman H, Overholser L, Patel C, Peterson L, Pirl W, Porpiglia A, Schapira L, Schwartz A, Smith S, Tevaarwerk A, Von Ah D, Wake R, Yang E, Zee P, McMillian N, Freedman-Cass D. NCCN Guidelines® Insights: Survivorship, Version 2.2024. Journal Of The National Comprehensive Cancer Network 2024, 22: 648-658. PMID: 39689426, DOI: 10.6004/jnccn.2024.0062.Peer-Reviewed Original ResearchBaseline predictors associated with successful weight loss among breast cancer survivors in the Lifestyle, Exercise, and Nutrition (LEAN) study
Hoobler R, Puklin L, Harrigan M, Cartmel B, Li F, Sanft T, Ferrucci L, Irwin M, Playdon M. Baseline predictors associated with successful weight loss among breast cancer survivors in the Lifestyle, Exercise, and Nutrition (LEAN) study. Journal Of Cancer Survivorship 2024, 1-9. PMID: 39528779, DOI: 10.1007/s11764-024-01702-3.Peer-Reviewed Original ResearchBreast cancer survivorsClinically meaningful weight lossCancer survivorsWeight loss interventionCancer SurvivorsBreast cancer survivorsWeight loss successConclusionBreast cancer survivorsPrevention of weight gainAssociated with lower oddsHistory of weight gainHealthy body weightMultivariate logistic regressionCancer treatmentSuccessful weight lossBreast cancer treatmentIntervention armLower oddsResultsBaseline dataDesign of programsWeight lossLogistic regressionC-statisticWeight gainSurvivorsInterventionBarriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study
Puklin L, Irwin M, Sanft T, Ferrucci L, Harrigan M, McGowan C, Cartmel B, Zupa M, Winer E, Deyling M, Ligibel J, Basen-Engquist K, Spiegelman D, Sharifi M. Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study. Supportive Care In Cancer 2024, 32: 590. PMID: 39141176, DOI: 10.1007/s00520-024-08789-5.Peer-Reviewed Original ResearchConceptsPhysical activityLifestyle interventionSelf-reported PA questionnaireSelf-reported diet qualityBreast cancerHealthy Eating Index-2015Stage I-III breast cancerBenefits of PASequential mixed methods studyI-III breast cancerChemotherapy-related symptomsMixed methods studyThematic content analysisBehavioral goalsSense of controlBody mass indexPA questionnaireSemi-structured interviewsMean body mass indexTranscribed verbatimIntervention armTailored educationDiet qualityNutritional behaviorMental benefitsExercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO)
Schmitz K, Brown J, Irwin M, Robien K, Scott J, Berger N, Caan B, Cercek A, Crane T, Evans S, Ligibel J, Meyerhardt J, Agurs-Collins T, Basen-Engquist K, Bea J, Cai S, Cartmel B, Chinchilli V, Demark-Wahnefried W, Dieli-Conwright C, DiPietro L, Doerksen S, Edelstein S, Elena J, Evans W, Ferrucci L, Foldi J, Freylersythe S, Furberg H, Jones L, Levine R, Moskowitz C, Owusu C, Penedo F, Rabin B, Ratner E, Rosenzweig M, Salz T, Sanft T, Schlumbrecht M, Spielmann G, Thomson C, Tjaden A, Weiser M, Yang S, Yu A, Perna F, Caan B, Anderson S, Bahia H, Castillo A, Feliciano E, Johnson K, Ross M, Weltzein E, Brown J, Albarado B, Compton S, Green T, Nash R, Nauta P, Welch M, Yang S, Meyerhardt J, Dieli-Conwright C, Nguyen D, Pena A, Spielmann G, Kim Y, Evans W, Bea J, Blew R, Crane T, Bhatti A, Clavon R, Erlandsen S, Freylersythe S, Hollander K, Lopez-Pentecost M, Penedo F, Rolle L, Rossi P, Schlumbrecht M, Wheeler M, Irwin M, Cao A, Cartmel B, Ferrucci L, Gottlieb L, Harrigan M, Li F, McGowan C, Puklin L, Ratner E, Sanft T, Zupa M, Berger N, Cerne S, Mills C, Conochan S, Hundal J, Owusu C, Ligibel J, Campbell N, DiGuglielmo K, Kemp W, Maples-Campbell C, Nguyen T, Oppenheim J, Tanasijevic A, Thomson C, Yung A, Basen-Engquist K, Loomba P, Chinchilli V, Schmitz K, Binder J, Doerksen S, Foldi J, Garrett S, Scalise R, Sobolewski M, White L, Scott J, Cercek A, Cai S, Cao S, Furberg H, Harrison J, Jones L, Lee C, Levine R, Michalski M, Moskowitz C, Novo R, Rabazzi J, Stoeckel K, Salz T, Weiser M, Yu A, Demark-Wahnefried W, Robien K, Evans S, DiPietro L, Duong B, Edelstein S, Helmchen L, Le D, McCleary C, Tjaden A, Wopat H, Rabin B, Perna F, Agurs-Collins T, Czajkowski S, Elena J, Nebeling L, Norton W. Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO). Journal Of The National Cancer Institute 2024, djae177. PMID: 39118255, DOI: 10.1093/jnci/djae177.Peer-Reviewed Original ResearchSelf-reported physical functionTreatment-related outcomesTreatment-related side effectsRisk of suboptimal outcomesExercise interventionOncology carePhysical functionNational Cancer InstituteNutrition ProgramIntervention effectsCommon Data ElementsExerciseCancer InstituteCommunity opportunitiesData elementsStandard of careInterventionCareCancer patientsNutritionRelative dose intensityOutcomesSuboptimal outcomesCancer treatmentChemotherapy relative dose intensityAnxiety and fear of cancer recurrence as predictors of subsequent pain interference in early cancer survivorship: Exploring the moderating roles of cognitive and emotional factors
Gnall K, Emrich M, Magin Z, Park C, Bellizzi K, Sanft T. Anxiety and fear of cancer recurrence as predictors of subsequent pain interference in early cancer survivorship: Exploring the moderating roles of cognitive and emotional factors. Journal Of Behavioral Medicine 2024, 47: 980-993. PMID: 39110352, DOI: 10.1007/s10865-024-00506-1.Peer-Reviewed Original ResearchFear of cancer recurrencePain interferenceCancer survivorsAssociated with greater pain interferenceGreater pain interferencePrimary cancer treatmentCancer recurrenceQuality of lifeCancer survivorshipLonger-term painSelf-report measuresEmotion regulation difficultiesCancer treatmentConsequence beliefsChronic beliefsCognitive/emotional factorsPsychological treatmentLongitudinal studyPotential moderatorsAnxietyRegulation difficultiesPainFollow-upEmotional factorsSurvivorsLongitudinal Curriculum to Address Wellness and Professional Development in a Hematology/Oncology Fellowship Program
Srikumar T, Stempel J, Goldberg S, Podoltsev N, Braun D, Lee A, Sanft T. Longitudinal Curriculum to Address Wellness and Professional Development in a Hematology/Oncology Fellowship Program. EMJ Oncology 2024, 1: 37-39. DOI: 10.33590/oncolamj/zgwb5064.Peer-Reviewed Original ResearchLongitudinal curriculum to address wellness and professional development in a hematology/oncology fellowship program.
Srikumar T, Stempel J, Goldberg S, Podoltsev N, Braun D, Lee A, Sanft T. Longitudinal curriculum to address wellness and professional development in a hematology/oncology fellowship program. Journal Of Clinical Oncology 2024, 42: 9004-9004. DOI: 10.1200/jco.2024.42.16_suppl.9004.Peer-Reviewed Original ResearchNeeds assessmentLongitudinal curriculumPatient Health Questionnaire 2Score of self-efficacyGeneral Self-Efficacy ScaleFellowship programsBaseline needs assessmentFaculty-led sessionsProfessional boundary settingSelf-Efficacy ScaleLevels of depressionProfessional developmentFirst-year fellowsDidactic sessionsPrevent burnoutChi-square testAcademic yearDebriefing sessionsQuestionnaire 2Baseline assessmentSelf-efficacyProfessional development skillsDepressed moodLeadership skillsBurnoutA medical school curriculum to foster the physician-patient relationship through narrative medicine.
Yao J, Hunter C, Jaber Chehayeb R, Sanft T, Prsic E, Dunne D, Kang-Giaimo A. A medical school curriculum to foster the physician-patient relationship through narrative medicine. Journal Of Clinical Oncology 2024, 42: e21015-e21015. DOI: 10.1200/jco.2024.42.16_suppl.e21015.Peer-Reviewed Original ResearchDoctor-patient relationshipPatient storiesNarrative medicineTraining sessionsStrong doctor-patient relationshipOptimal quality careThird-year medical studentsPhysician-patient relationshipMedical school curriculumYear medical studentsImprove well-beingMedical education toolThematic analysis of responsesNarrative medicine curriculumDoctor patient relationshipPre-clerkship studentsMedicine skillsYale School of MedicineQuality careMedical students' senseMedicine curriculumPatient relationshipThematic analysisInterviewed patientsSchool of MedicineImproving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial
Puklin L, Ferrucci L, Harrigan M, McGowan C, Zupa M, Cartmel B, Li F, Ligibel J, Spiegelman D, Sharifi M, Sanft T, Irwin M. Improving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial. Cancer 2024, 130: 2440-2452. PMID: 38470431, PMCID: PMC11214600, DOI: 10.1002/cncr.35280.Peer-Reviewed Original ResearchPhysical activityDiet qualityHEI-2015Strength trainingLifestyle behaviorsHealthy Eating Index (HEI)-2015Breast cancerAssociated with baseline fatigueImprove physical activityImprove lifestyle behaviorsHigher HEI-2015Associated with higher oddsExercise interventionUsual careIntervention armIntervention groupBaseline fatigueLifestyle interventionYearlong interventionLower fatigueHigher oddsSecondary analysisLogistic regressionNewly diagnosed patientsStudy armsImpact of the Breast Cancer Index for Extended Endocrine Decision-Making: First Results of the Prospective BCI Registry Study.
Sanft T, Wong J, O'Neal B, Siuliukina N, Jankowitz R, Pegram M, Fox J, Zhang Y, Treuner K, O'Shaughnessy J. Impact of the Breast Cancer Index for Extended Endocrine Decision-Making: First Results of the Prospective BCI Registry Study. Journal Of The National Comprehensive Cancer Network 2024, 22: 99-107. PMID: 38437792, DOI: 10.6004/jnccn.2023.7087.Peer-Reviewed Original ResearchBenefit of endocrine therapyBreast Cancer IndexPatient satisfactionEndocrine therapyRegistry studyReduce patient concernsPhysician decision-makingClinical practiceEarly-stage breast cancerIncrease physician confidenceCancer indexHormone receptor-positive early-stage breast cancerDrug safetyPhysician recommendationMedication adherencePhysician confidenceWilcoxon signed rank testPatient concernsClinical careDecision-makingPatient preferencesLate distant recurrencePhysiciansTest questionnaireLong-term outcomesPhysical health and function trajectories in adults with cancer: psychosocial predictors of class membership
Bellizzi K, Park C, Lee J, Harel O, Sanft T, Fritzson E, Salafia C, Ligus K, Gnall K, Magin Z. Physical health and function trajectories in adults with cancer: psychosocial predictors of class membership. Journal Of Cancer Survivorship 2024, 1-11. PMID: 38289507, PMCID: PMC11286833, DOI: 10.1007/s11764-024-01540-3.Peer-Reviewed Original ResearchPhysical healthTrajectory class membershipPsychosocial predictorsGeneral healthDiagnosed adult cancer patientsHealth survey measuresFunction trajectoriesAdult cancer patientsPredictors of trajectory class membershipMultinomial logistic regression modelLogistic regression modelsTrajectory of recoveryPhysical functionBodily painSF-12Estimate associationsBaseline assessmentDeclining scoresYale Cancer CenterClass membershipGrowth mixture modelingPattern of predictorsLogistic regressionDaily activitiesHealth
2023
Post-diagnosis weight trajectories and mortality among women with breast cancer
Puklin L, Li F, Cartmel B, Zhao J, Sanft T, Lisevick A, Winer E, Lustberg M, Spiegelman D, Sharifi M, Irwin M, Ferrucci L. Post-diagnosis weight trajectories and mortality among women with breast cancer. Npj Breast Cancer 2023, 9: 98. PMID: 38042922, PMCID: PMC10693588, DOI: 10.1038/s41523-023-00603-5.Peer-Reviewed Original ResearchBody mass indexBreast cancer diagnosisWeight changeCause mortalityClinical characteristicsWeight gainWeight lossBreast cancerWeight trajectoriesPost-diagnosis weight changeBreast cancer-specific mortalityCox proportional hazards modelModern treatment eraCancer-specific mortalityCancer diagnosisModerate weight lossModerate weight gainProportional hazards modelAdverse health outcomesElectronic health recordsTreatment eraBaseline characteristicsTumor RegistryMass indexWeight managementSIOG2023-5-P-388 Social support buffers the effect of social deprivation on comorbidity burden in adults with cancer
Bellizzi K, Ligus K, Salafia C, Sanft T, Park C. SIOG2023-5-P-388 Social support buffers the effect of social deprivation on comorbidity burden in adults with cancer. Journal Of Geriatric Oncology 2023, 14: s81-s82. DOI: 10.1016/s1879-4068(23)00426-5.Peer-Reviewed Original ResearchA qualitative study on the role of financial toxicity on adoption of healthy lifestyle behavior after breast cancer among Black and Latina women.
Nsubayi C, Pichardo M, Ginader A, Peña K, Nguyen T, Irwin M, Sanft T, Fayanju O, Molina Y. A qualitative study on the role of financial toxicity on adoption of healthy lifestyle behavior after breast cancer among Black and Latina women. JCO Oncology Practice 2023, 19: 273-273. DOI: 10.1200/op.2023.19.11_suppl.273.Peer-Reviewed Original ResearchLocal organizationsBreast cancer survivorsQualitative interview dataLatina breast cancer survivorsLatina womenLifestyle behavior changeHousing insecuritySocial workersCancer survivorsInstitutional levelLevel of accessInterview dataIdentified strategiesFinancial toxicityInterpersonal levelCommunity levelFinancial resourcesQualitative studyBreast cancerInductive approachContent analysisTypes of resourcesFinancial hardshipThematic categoriesBehavior changeRandomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors
Puklin L, Harrigan M, Cartmel B, Sanft T, Gottlieb L, Zhou B, Ferrucci L, Li F, Spiegelman D, Sharifi M, Irwin M. Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors. Cancers 2023, 15: 4719. PMID: 37835412, PMCID: PMC10571774, DOI: 10.3390/cancers15194719.Peer-Reviewed Original ResearchBreast cancer survivorsCancer survivorsLifestyle interventionPhysical activityQuality of lifeBody weightWaitlist groupDiet qualitySelf-reported body weightWeight lossFavorable weight changeHealthy weight lossBody mass indexHealthy body weightGreater weight lossEvidence-based materialsDiverse healthcare settingsIntervention armMass indexClinical practicePositive behavior changeHealthcare settingsSurvivorsWeight changeInterventionPrevalence and Correlates of Cannabis Use among U.S. Veterans during the Second Wave of the COVID-19 Pandemic
Manzo L, Sarkar S, Nicholson N, Sanft T, Poghosyan H. Prevalence and Correlates of Cannabis Use among U.S. Veterans during the Second Wave of the COVID-19 Pandemic. Military Medicine 2023, 189: e1230-e1239. PMID: 37715685, DOI: 10.1093/milmed/usad360.Peer-Reviewed Original ResearchCurrent tobacco smokersE-cigarette useComorbid conditionsTobacco smokersU.S. veteransNon-Hispanic Black veteransMultivariable logistic regression analysisSurvey's complex designMore comorbid conditionsNon-Hispanic white veteransFrequent mental distressHigh-risk subgroupsCoronavirus disease 2019 (COVID-19) pandemicMilitary veteransCurrent e-cigarette useCurrent e-cigarette usersLogistic regression analysisNon-Hispanic blacksTimes higher oddsSubstance use disordersDisease 2019 pandemicCOVID-19 pandemicNon-Hispanic whitesE-cigarette usersFormer smokersRandomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study
Sanft T, Harrigan M, McGowan C, Cartmel B, Zupa M, Li F, Ferrucci L, Puklin L, Cao A, Nguyen T, Neuhouser M, Hershman D, Basen-Engquist K, Jones B, Knobf T, Chagpar A, Silber A, Tanasijevic A, Ligibel J, Irwin M. Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study. Journal Of Clinical Oncology 2023, 41: 5285-5295. PMID: 37656930, PMCID: PMC10691793, DOI: 10.1200/jco.23.00871.Peer-Reviewed Original ResearchConceptsRelative dose intensityPathologic complete responseProportion of patientsBreast cancerNeoadjuvant chemotherapyChemotherapy completionComplete responseNutrition interventionsHigher pathologic complete responseHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Triple-negative breast cancerChemotherapy dose adjustmentsHome-based exerciseGrowth factor receptor 2Breast cancer outcomesEffects of exerciseFactor receptor 2Electronic medical recordsChi-square testUsual careDose intensityExercise interventionDose adjustmentRandomized trialsNCCN Guidelines® Insights: Survivorship, Version 1.2023.
Sanft T, Day A, Ansbaugh S, Armenian S, Baker K, Ballinger T, Demark-Wahnefried W, Dickinson K, Fairman N, Felciano J, Flores T, Friedman D, Gabel N, Goldman M, Henry N, Hill-Kayser C, Hudson M, Koura D, Lee K, McDonough A, Melisko M, Mooney K, Moore H, Moryl N, Neuman H, O'Connor T, Overholser L, Paskett E, Patel C, Peterson L, Pirl W, Porpiglia A, Rodriguez M, Schapira L, Schwartz A, Smith S, Tevaarwerk A, Yang E, Zee P, McMillian N, Freedman-Cass D. NCCN Guidelines® Insights: Survivorship, Version 1.2023. Journal Of The National Comprehensive Cancer Network 2023, 21: 792-803. PMID: 37549906, DOI: 10.6004/jnccn.2023.0041.Peer-Reviewed Original ResearchConceptsCancer survivorsCognitive functionNCCN guidelinesHealthy behaviorsNCCN Guidelines InsightsAdult-onset cancersSleep disordersRecent guideline updatesVaried needsGuideline updateTreatment recommendationsCare coordinationSurvivorsPhysical problemsDisordersGuidelinesProfessionalsImmunizationCancerSurvivorshipBehaviorRecommendationsPersistence to extended adjuvant endocrine therapy following Breast Cancer Index (BCI) testing in women with early-stage hormone receptor-positive (HR +) breast cancer
Foldi J, Tsagianni A, Salganik M, Schnabel C, Brufsky A, van Londen G, Pusztai L, Sanft T. Persistence to extended adjuvant endocrine therapy following Breast Cancer Index (BCI) testing in women with early-stage hormone receptor-positive (HR +) breast cancer. BMC Cancer 2023, 23: 606. PMID: 37391697, PMCID: PMC10314405, DOI: 10.1186/s12885-023-11104-w.Peer-Reviewed Original ResearchConceptsAdjuvant endocrine therapyEarly-stage hormone receptor-positive breast cancerHormone receptor-positive breast cancerReceptor-positive breast cancerEndocrine therapyBreast cancerLate breast cancer recurrenceExtended endocrine therapyNon-persistence ratesIntolerable side effectsBone density scanBreast cancer recurrenceHigher likelihoodRate of persistenceElectronic health recordsConclusionsIn patientsMedication persistenceTreatment persistenceLow patientsMetastatic recurrenceCancer recurrenceCommon reasonSide effectsPatientsStage IOral paclitaxel and dostarlimab with or without trastuzumab in early-stage, high-risk breast cancer: Results from the neoadjuvant ISPY 2 TRIAL.
Shatsky R, Thomas A, Yau C, Chien A, Falkson C, Stringer-Reasor E, Omene C, Trivedi M, Boughey J, Sanford A, Arora M, Sanft T, Nanda R, Isaacs C, Brown T, Hylton N, DeMichele A, Yee D, Esserman L. Oral paclitaxel and dostarlimab with or without trastuzumab in early-stage, high-risk breast cancer: Results from the neoadjuvant ISPY 2 TRIAL. Journal Of Clinical Oncology 2023, 41: lba612-lba612. DOI: 10.1200/jco.2023.41.17_suppl.lba612.Peer-Reviewed Original ResearchImmune related adverse eventsWeeks x 4High-risk breast cancerPD-1 inhibitorsPathologic complete responseOral paclitaxelPeripheral neuropathyControl armBreast cancerRates of neutropeniaEfficacy of immunotherapyPhase 2 trialRelated adverse eventsHigh-risk cancerBiomarker subtypesI-SPY2Neoadjuvant agentWeekly trastuzumabOral agentsPrimary endpointAdverse eventsComplete responseOral combinationCombination therapyPump inhibitors