2011
Axial creep loading and unloaded recovery of the human intervertebral disc and the effect of degeneration
O’Connell G, Jacobs NT, Sen S, Vresilovic EJ, Elliott DM. Axial creep loading and unloaded recovery of the human intervertebral disc and the effect of degeneration. Journal Of The Mechanical Behavior Of Biomedical Materials 2011, 4: 933-942. PMID: 21783103, PMCID: PMC3143379, DOI: 10.1016/j.jmbbm.2011.02.002.Peer-Reviewed Original Research
2008
Effect of Degeneration on the Dynamic Viscoelastic Properties of Human Annulus Fibrosus in Tension
Sen S, Boxberger J, Schroeder Y, Orias A, Elliott D. Effect of Degeneration on the Dynamic Viscoelastic Properties of Human Annulus Fibrosus in Tension. 2008, 609-610. DOI: 10.1115/sbc2008-193057.Peer-Reviewed Original ResearchDisc degenerationViscoelastic propertiesStructural finite element modelIntervertebral disc degenerationFinite element modelUniaxial tensile testsPhysiological cyclic loadingQuasi-static conditionsHuman AF tissueDynamic viscoelastic propertiesStatic viscoelastic propertiesAF tissueCyclic loadingElement modelTensile testsIntervertebral discMechanical assessmentRegenerative approachesTissueDegenerate tissueMechanical functionDegenerationAn In Vivo Model of Reduced Nucleus Pulposus Glycosaminoglycan Content in the Rat Lumbar Intervertebral Disc
Boxberger JI, Auerbach JD, Sen S, Elliott DM. An In Vivo Model of Reduced Nucleus Pulposus Glycosaminoglycan Content in the Rat Lumbar Intervertebral Disc. Spine 2008, 33: 146-154. PMID: 18197098, PMCID: PMC2696404, DOI: 10.1097/brs.0b013e31816054f8.Peer-Reviewed Original ResearchConceptsRange of motionVivo modelDisc degenerationEarly stage disc degenerationRat lumbar intervertebral discsRat lumbar spineDevelopment of therapiesIntervertebral disc degenerationLumbar intervertebral discsHistology 4Glycosaminoglycan contentDisease progressionBACKGROUND DATALumbar spineAnimal modelsAltered biochemistryEarly interventionGlycosaminoglycan levelsGlycosaminoglycan lossPhysiologic levelsDegenerationControl levelsIntervertebral discNucleus pulposusWeeks