2020
Factors Associated With Large Improvements in Health-Related Quality of Life in Patients With Atrial Fibrillation
Steinberg BA, Holmes DN, Pieper K, Allen LA, Chan PS, Ezekowitz MD, Freeman JV, Fonarow GC, Gersh BJ, Hylek EM, Kowey PR, Mahaffey KW, Naccarelli G, Reiffel J, Singer DE, Peterson ED, Piccini JP, Mendelson R, Nahhas A, Neutel J, Padanilam B, Pan D, Poock J, Raffetto J, Greengold R, Roan P, Saba F, Sackett M, Schneider R, Seymour Z, Shanes J, Shoemaker J, Simms V, Smiley N, Smith D, Snipes C, Sotolongo R, Staniloae C, Stoltz S, Suresh D, Tak T, Tannenbaum A, Turk S, Vora K, Randhawa P, Zebrack J, Silva E, Riley E, Weinstein D, Vasiliauskas T, Goldbarg S, Hayward D, Yarlagadda C, Laurion D, Osunkoya A, Burns R, Castor T, Spiller D, Luttman C, Anton S, McGarvey J, Guthrie R, Deriso G, Flood R, Fleischer L, Fierstein J, Aggarwal R, Jacobs G, Adjei N, Akyea-Djamson A, Alfieri A, Bacon J, Bedwell N, Berger P, Berry J, Bhagwat R, Bloom S, Boccalandro F, Capo J, Kapadia S, Casanova R, Morriss III J, Christensen T, Elsen J, Farsad R, Fox D, Frandsen B, Gelernt M, Gill S, Grubb S, Hall C, Harris H, Hotchkiss D, Ip J, Jaffrani N, Jones A, Kazmierski J, Waxman F, Kneller G, Labroo A, Jaffe B, Lebenthal M, Lee D, Lillestol M, LeClerc K, Maccaro P, Mayer N, Kozlowski J, Benjamin S, Detweiler R, Igic P, Jackson T, Pappas J, Littlefield R, Frey A, Vranian R, Long W, Grena P, Arouni A, Quinn J, Browne K, Forman S, Ebinger M, Blonder R, Snyder H, Slabic S, Williams D, Stein R, Kirkland S, Cohen K, Walthall W, Davis K, Snoddy B, Alvarado O, Leach C, Rothman S, Sharma A, Olatidoye A, AlMahameed S, Rosenthal S, Sutter G, Reiter W, Thompson T, Thew S, Kobayashi J, Williams M, Kramer J, Latif S, Rhee B, Adler A, Ruiz-Serrano D, Stringam S, Wolok K, Focil A, Butman S, Ingersoll H, Borge R, Al-Saghir Y, Coats P, Farris N, Shore K, Schwartz M, Gornick C, Eilat P, Quinlan E, Paliwal Y, Mitra R, Jingo A, Aslam A, Watson R, Voyce S, Turakhia M, Goytia-Leos D, Lurie M, Mallis G, Atwater B, Strobel J, Murray J, Fisher D, Atieh M, Landes R, Drabick A, Harman E, Ashcraft B, Krista M, Videlefsky A, Rivera Zayas E, Tan A. Factors Associated With Large Improvements in Health-Related Quality of Life in Patients With Atrial Fibrillation. Circulation Arrhythmia And Electrophysiology 2020, 13: e007775. PMID: 32298144, PMCID: PMC7247417, DOI: 10.1161/circep.119.007775.Peer-Reviewed Original ResearchConceptsAntiarrhythmic drug useHRQoL improvementAtrial fibrillationPrior stroke/transient ischemic attackStroke/transient ischemic attackDrug useBaseline diastolic blood pressureChronic obstructive pulmonary diseaseAtrial Fibrillation EffectAF risk factorsTransient ischemic attackPeripheral arterial diseaseBetter Informed TreatmentDiastolic blood pressureHealth-related qualityObstructive pulmonary diseasePatient-reported outcomesQuality of lifeIschemic attackHigh-value careBlood pressurePulmonary diseaseArterial diseaseMultivariable analysisOutcomes Registry
2015
Heart rate is associated with progression of atrial fibrillation, independent of rhythm
Holmqvist F, Kim S, Steinberg BA, Reiffel JA, Mahaffey KW, Gersh BJ, Fonarow GC, Naccarelli GV, Chang P, Freeman JV, Kowey PR, Thomas L, Peterson ED, Piccini JP. Heart rate is associated with progression of atrial fibrillation, independent of rhythm. Heart 2015, 101: 894. PMID: 25732748, PMCID: PMC4453487, DOI: 10.1136/heartjnl-2014-307043.Peer-Reviewed Original ResearchConceptsAtrial fibrillationAF progressionHeart rateBaseline ECGRhythm control strategyBetter Informed TreatmentPredictors of progressionPersistent atrial fibrillationModest discriminatory powerLower heart rateHigher heart rateMore comorbiditiesOutcomes RegistryPatientsClinical practiceInformed TreatmentProgressionStrongest predictorFibrillationPredictorsBaselineAgeECGSustained formsSignificant interaction
2011
The Impact of ST Elevation on Athletic Screening
Leo T, Uberoi A, Jain NA, Garza D, Chowdhury S, Freeman JV, Perez M, Ashley E, Froelicher V. The Impact of ST Elevation on Athletic Screening. Clinical Journal Of Sport Medicine 2011, 21: 433-440. PMID: 21892017, DOI: 10.1097/jsm.0b013e31822cf105.Peer-Reviewed Original ResearchConceptsST elevationCardiac eventsCardiac deathEarly repolarizationVeterans Affairs Palo Alto Health Care SystemRetrospective cohort studyAbnormal test resultsClinical patient cohortUniversity varsity athletesHealth care systemCardiovascular mortalityCohort studyClinical outcomesAmbulatory individualsVital statusAthletic screeningECG abnormalitiesPatient cohortLateral leadsMyocardial ischemiaBrugada syndromeHigh prevalenceCardiac conditionsHeart rateJ waves
2008
Prediction of Cardiovascular Death using a Novel Heart Rate Recovery Parameter
HADLEY DM, DEWEY FE, FREEMAN JV, MYERS JN, FROELICHER VF. Prediction of Cardiovascular Death using a Novel Heart Rate Recovery Parameter. Medicine & Science In Sports & Exercise 2008, 40: 1072-1079. PMID: 18460999, DOI: 10.1249/mss.0b013e318167665a.Peer-Reviewed Original ResearchConceptsDuke treadmill scoreHeart rate recoveryHR increaseCV mortalityVagal toneCardiovascular causesCardiovascular deathPeak exerciseLowest tertileTreadmill scoreCox analysisClinical parametersMaximal exerciseSympathetic influencesExercise indexRate recoveryVagal influencePrognostic measurementMortalityPatientsRecovery variablesNormal scoresScoresExerciseRecovery parameters
2007
Novel predictor of prognosis from exercise stress testing: Heart rate variability response to the exercise treadmill test
Dewey FE, Freeman JV, Engel G, Oviedo R, Abrol N, Ahmed N, Myers J, Froelicher VF. Novel predictor of prognosis from exercise stress testing: Heart rate variability response to the exercise treadmill test. American Heart Journal 2007, 153: 281-288. PMID: 17239690, DOI: 10.1016/j.ahj.2006.11.001.Peer-Reviewed Original ResearchConceptsHeart rate variabilitySquare successive differenceCardiovascular mortalityPrognostic powerHF powerExercise treadmill testingRoot mean square successive differenceFrequency-domain HRV analysisExercise stress testingExercise treadmill testMortality end pointsSuccessive differencesStandard exercise testingHeart rate variability responsesMinutes of recoveryStrongest predictorLow-frequency powerMean square successive differenceHigh-frequency powerR interval dataCardiovascular deathCause mortalityPeak exerciseClinical factorsExercise testing
2006
Autonomic Nervous System Interaction With the Cardiovascular System During Exercise
Freeman JV, Dewey FE, Hadley DM, Myers J, Froelicher VF. Autonomic Nervous System Interaction With the Cardiovascular System During Exercise. Progress In Cardiovascular Diseases 2006, 48: 342-362. PMID: 16627049, DOI: 10.1016/j.pcad.2005.11.003.Peer-Reviewed Original ResearchConceptsExercise testHR variabilityHR recoveryCardiovascular systemSudden cardiac deathAutonomic nervous system interactionsSignificant prognostic informationAutonomic nervous systemHeart rate responseStandard exercise testNervous system interactionsConsiderable recent evidenceExercise testingCardiac deathPrognostic significancePrognostic valuePrognostic informationCardiovascular patientsExercise measurementsHR responseNervous systemRate responseRecent evidenceExerciseFuture findings