2022
Prognosis of hospitalized patients with cirrhosis and acute kidney disease
Wong F, Garcia‐Tsao G, Reddy KR, O'Leary JG, Kamath PS, Tandon P, Lai JC, Vargas HE, Biggins SW, Fallon MB, Thuluvath PJ, Maliakkal BJ, Subramanian R, Thacker L, Bajaj JS. Prognosis of hospitalized patients with cirrhosis and acute kidney disease. Liver International 2022, 42: 896-904. PMID: 35023264, PMCID: PMC11075740, DOI: 10.1111/liv.15154.Peer-Reviewed Original ResearchConceptsAcute kidney diseaseStage 1 AKIAKD patientsPeak ScrAKI patientsCirrhotic patientsKidney diseaseSecond infectionEnd-stage liver diseaseDecompensated cirrhotic patientsHigher hospital admissionsWorse renal dysfunctionNormal renal functionGlomerular filtration rateNorth American ConsortiumBaseline SCrRenal dysfunctionPrompt treatmentRenal functionSerum creatinineHospital admissionClinical outcomesLiver diseasePredictive factorsFiltration rate
2012
Spontaneous bacterial peritonitis
Garcia‐Tsao G. Spontaneous bacterial peritonitis. 2012, 745-750. DOI: 10.1002/9781118321386.ch100.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSpontaneous bacterial peritonitisBacterial peritonitisPoor liver synthetic functionShort-term antibiotic prophylaxisCompatible clinical pictureHospitalized cirrhotic patientsLiver synthetic functionPolymorphonuclear cell countAntibiotic prophylaxisDiagnostic paracentesisIntravenous antibioticsOral norfloxacinSecondary prophylaxisGastrointestinal bleedGastrointestinal hemorrhageLiver transplantationRenal dysfunctionAlbumin therapyCirrhotic patientsAcute infectionImportant complicationClinical pictureCommon infectionsActive infectionPatients
2011
Ascites
Garcia‐Tsao G. Ascites. 2011, 210-233. DOI: 10.1002/9781444341294.ch10.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHepatorenal syndromeBacterial infectionsBaseline renal dysfunctionPeripheral arterial vasodilatationAcute kidney injurySecond-line treatmentMainstay of treatmentSpontaneous bacterial peritonitisSympathetic nervous systemEffective blood volumeSpontaneous bacterial infectionsCommon bacterial infectionsSigns of infectionLong-term safetyDiagnostic paracentesisIntravenous albuminPrerenal typeSinusoidal hypertensionAldosterone systemArterial vasodilatationKidney injuryLiver transplantationRefractory ascitesRenal dysfunctionSodium restriction
2010
Renal Dysfunction Is the Most Important Independent Predictor of Mortality in Cirrhotic Patients With Spontaneous Bacterial Peritonitis
Tandon P, Garcia–Tsao G. Renal Dysfunction Is the Most Important Independent Predictor of Mortality in Cirrhotic Patients With Spontaneous Bacterial Peritonitis. Clinical Gastroenterology And Hepatology 2010, 9: 260-265. PMID: 21145427, PMCID: PMC3713475, DOI: 10.1016/j.cgh.2010.11.038.Peer-Reviewed Original ResearchConceptsRenal dysfunctionCirrhotic patientsBacterial peritonitisAscitic fluid cell countHigh-risk patientsMain prognostic factorsNormal renal functionSpontaneous bacterial peritonitisHigh-risk groupImportant independent predictorBlood urea nitrogenGood quality studiesSBP resolutionVasoconstrictor therapyMELD scoreAdult patientsRenal functionIndependent predictorsMedian agePrognostic factorsRisk stratificationCommon infectionsImmunosuppressive factorsPrognostic valuePrognostic studies
2008
Acute kidney injury in cirrhosis
Garcia‐Tsao G, Parikh CR, Viola A. Acute kidney injury in cirrhosis. Hepatology 2008, 48: 2064-2077. PMID: 19003880, DOI: 10.1002/hep.22605.Peer-Reviewed Original ResearchConceptsAcute kidney injuryAcute renal failureHepatorenal syndromeKidney injurySerum creatinineSpecific therapyEffective arterial blood volumeUseful bridging therapyAcute tubular necrosisRenal blood flowSpontaneous bacterial peritonitisArterial blood volumeBridging therapyLiver transplantationPrerenal azotemiaRenal dysfunctionRenal failureTubular necrosisBacterial peritonitisVasodilatory stateRelative hypovolemiaVolume repletionCommon causeCirrhosisBlood flow
2004
Treatment of acute variceal bleeding: general management and prevention of infections
Garcia-Tsao G. Treatment of acute variceal bleeding: general management and prevention of infections. 2004, 233-240. DOI: 10.1007/978-94-007-1042-9_25.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsVariceal bleedingCirrhotic patientsPoor outcomePredictive factorsHepatic venous pressure gradientUpper gastrointestinal bleeding episodesActive variceal bleedingEarly recurrent bleedingAcute variceal bleedingVenous pressure gradientGastrointestinal bleeding episodesPrevention of infectionAlcoholic etiologyBleeding episodesGastrointestinal hemorrhageRecurrent bleedingRenal dysfunctionVariceal hemorrhageLiver dysfunctionEsophageal varicesUncontrolled bleedingDiagnostic endoscopyHepatocellular carcinomaBleedingPatients
2003
The management of ascites in cirrhosis: Report on the consensus conference of the international Ascites club
Moore K, Wong F, Gines P, Bernardi M, Ochs A, Salerno F, Angeli P, Porayko M, Moreau R, Garcia‐Tsao G, Jimenez W, Planas R, Arroyo V. The management of ascites in cirrhosis: Report on the consensus conference of the international Ascites club. Hepatology 2003, 38: 258-266. PMID: 12830009, DOI: 10.1053/jhep.2003.50315.Peer-Reviewed Original ResearchConceptsTransjugular intrahepatic portosystemic stent shuntInternational Ascites ClubDiuretic therapyRefractory ascitesColloid volume expansionModest salt restrictionLarge-volume paracentesisManagement of ascitesDevelopment of ascitesHepatic decompensationModerate ascitesGross ascitesLiver transplantationRenal dysfunctionSalt restrictionSodium excretionSodium restrictionTherapeutic paracentesisRenal functionSurvival benefitCommon complicationLiver diseasePancreatic ascitesAscitic patientsTIPS placement