1996
IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury.
Redlich C, Gao X, Rockwell S, Kelley M, Elias J. IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury. The Journal Of Immunology 1996, 157: 1705-10. PMID: 8759759, DOI: 10.4049/jimmunol.157.4.1705.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBronchoalveolar Lavage FluidCell LineGene Expression RegulationGene Expression Regulation, NeoplasticInjections, SubcutaneousInterleukin-11Lung NeoplasmsMacrophages, AlveolarMiceMice, Inbred BALB CNeoplasm ProteinsNeoplastic Stem CellsRadiation Injuries, ExperimentalRecombinant ProteinsRNA, MessengerRNA, NeoplasmSpecific Pathogen-Free OrganismsThoracic InjuriesTumor Necrosis Factor-alphaConceptsThoracic irradiationThoracic injuriesControl miceTNF protein productionTNF productionVehicle-treated control miceNormal thoracic structuresPulmonary metastatic tumorsEMT6 tumor cellsTNF mRNA expressionDose of radiationLung metastasesInhibits LPSMetastatic tumorsNormal lungRadioprotective effectMRNA expressionIL-11Enhances SurvivalTumor cellsObserved protectionSignificant radioprotectionTNF mRNAThoracic structuresStudy interval
1995
Retinoic acid inhibition of transforming growth factor-beta-induced collagen production by human lung fibroblasts.
Redlich C, Delisser H, Elias J. Retinoic acid inhibition of transforming growth factor-beta-induced collagen production by human lung fibroblasts. American Journal Of Respiratory Cell And Molecular Biology 1995, 12: 287-295. PMID: 7873195, DOI: 10.1165/ajrcmb.12.3.7873195.Peer-Reviewed Original ResearchConceptsHuman lung fibroblastsRetinoic acidCollagen productionChronic inflammatory lung disordersDoses of RALung fibroblastsType IInhibitory effectInflammatory lung disordersTrans retinoic acidFibroblast collagen productionM retinoic acidLung disordersPotent immunomodulatorFibrotic responseRetinoid compoundsType III collagenBasal levelsSignificant inhibitionAcid inhibitionSignificant decreaseRetinoidsUnstimulated cellsPreincubationStimulation