2022
Reducing asthma exacerbations in vulnerable children through a medical–legal partnership
Mainardi AS, Harris D, Rosenthal A, Redlich CA, Hu B, Fenick AM. Reducing asthma exacerbations in vulnerable children through a medical–legal partnership. Journal Of Asthma 2022, 60: 262-269. PMID: 35188437, DOI: 10.1080/02770903.2022.2045307.Peer-Reviewed Original ResearchConceptsMedical-legal partnershipsAsthma exacerbationsEmergency departmentHealth disparitiesAsthma exacerbation ratePrimary care officesAcademic children's hospitalAsthma health disparitiesExacerbation rateHealthcare utilizationPediatric populationChildren's HospitalCare officesPrimary careWorse outcomesChronic illnessInpatient settingStudy populationAsthmaTotal encountersSocial determinantsHospitalizationExacerbationStatistical significanceIntervention
2020
Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology
Wisnewski AV, Liu J, Redlich CA. Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology. American Journal Of Respiratory Cell And Molecular Biology 2020, 0: 25-35. PMID: 32101465, PMCID: PMC7328250, DOI: 10.1165/rcmb.2019-0400oc.Peer-Reviewed Original ResearchConceptsRespiratory tract exposureAirway eosinophiliaMonocytes/macrophagesMouse modelGene expressionGene transcriptsBiological pathwaysAsthma pathologyUpregulated gene transcriptsIgE-independent mechanismsLung gene expressionLung tissue gene expressionCause of asthmaBALB/cTransgenic B cellsTissue gene expressionExpression changesDiisocyanate asthmaSensitized workersAsthma pathogenesisAirway fluidDeficient miceMRNA microarrayEosinophiliaB cells
2019
Respiratory Health after Military Service in Southwest Asia and Afghanistan. An Official American Thoracic Society Workshop Report
Garshick E, Abraham JH, Baird CP, Ciminera P, Downey GP, Falvo MJ, Hart JE, Jackson DA, Jerrett M, Kuschner W, Helmer DA, Jones KD, Krefft SD, Mallon T, Miller RF, Morris MJ, Proctor SP, Redlich CA, Rose CS, Rull RP, Saers J, Schneiderman AI, Smith NL, Yiallouros P, Blanc PD. Respiratory Health after Military Service in Southwest Asia and Afghanistan. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2019, 16: e1-e16. PMID: 31368802, PMCID: PMC6774741, DOI: 10.1513/annalsats.201904-344ws.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsConstrictive bronchiolitisAirway diseaseRespiratory healthOfficial American Thoracic Society Workshop ReportRespiratory tract findingsRespiratory tract abnormalitiesAdverse health conditionsParticulate matter effectsU.S. military personnelLung biopsyLung functionPulmonary functionCase seriesPathologic findingsTract abnormalitiesInhalational exposurePhysiologic changesClinical characterizationAmerican Thoracic Society International ConferenceEpidemiologic studiesBronchiolitisLongitudinal assessmentDeployment exposuresHealth conditionsMore frequent encounters
2017
Improving the asthma disparity gap with legal advocacy? A qualitative study of patient-identified challenges to improve social and environmental factors that contribute to poorly controlled asthma
Harris DA, Mainardi A, Iyamu O, Rosenthal MS, Bruce RD, Pisani MA, Redlich CA. Improving the asthma disparity gap with legal advocacy? A qualitative study of patient-identified challenges to improve social and environmental factors that contribute to poorly controlled asthma. Journal Of Asthma 2017, 55: 924-932. PMID: 28872933, DOI: 10.1080/02770903.2017.1373393.Peer-Reviewed Original ResearchConceptsPoor symptom controlSymptom controlAsthma Control Test scoresCommon barriersCommunity health centersWork-related symptomsEnvironmental risk factorsPercent of participantsCommunity-engaged approachAsthmatic adultsAsthma controlRisk factorsAsthma triggersHealth centersImproved outcomesMedical careDisparity gapStudy participantsPerson interviewsLack of awarenessAsthmaPatientsConstant comparative methodEnvironmental factorsAdults
2014
Official American Thoracic Society Technical Standards: Spirometry in the Occupational Setting
Redlich CA, Tarlo SM, Hankinson JL, Townsend MC, Eschenbacher WL, Von Essen SG, Sigsgaard T, Weissman DN. Official American Thoracic Society Technical Standards: Spirometry in the Occupational Setting. American Journal Of Respiratory And Critical Care Medicine 2014, 189: 983-993. PMID: 24735032, DOI: 10.1164/rccm.201402-0337st.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLung functionChronic obstructive pulmonary diseaseObstructive pulmonary diseasePosture-related changesInterpretation of spirometryEMBASE 1980Pulmonary diseaseSpirometry testingLung diseaseMedline 1950SpirometryClinical informationInhalation exposureRepeat testingSystematic reviewHealth programsLongitudinal changesOccupational settingsPercentage declineSpirometry techniciansFEV1Appropriate reference valuesReference valuesWorker exposureDisease
2012
Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based on Serum Levels of HDI-Specific IgG
Wisnewski AV, Stowe MH, Nerlinger A, Opare-addo P, Decamp D, Kleinsmith CR, Redlich CA. Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based on Serum Levels of HDI-Specific IgG. Annals Of Work Exposures And Health 2012, 56: 901-910. PMID: 22449630, PMCID: PMC3471419, DOI: 10.1093/annhyg/mes024.Peer-Reviewed Original ResearchConceptsPersonal protective equipmentSkin exposureExposure surveillanceSpecific serum immunoglobulin GHexamethylene diisocyanate exposureSerum IgG levelsSerum immunoglobulin GNight shift workEnzyme-linked immunosorbentAdverse health effectsAsthma historyDiisocyanate exposureIgG levelsSerum levelsIgG titersChemical allergensPPE useImmune responseRespirator useIsocyanate exposureExposure biomarkersPractical biomarkersBasic demographicsHigh titersHygiene efforts
2011
An Official American Thoracic Society Statement: Work-Exacerbated Asthma
Henneberger PK, Redlich CA, Callahan DB, Harber P, Lemière C, Martin J, Tarlo SM, Vandenplas O, Torén K. An Official American Thoracic Society Statement: Work-Exacerbated Asthma. American Journal Of Respiratory And Critical Care Medicine 2011, 184: 368-378. PMID: 21804122, DOI: 10.1164/rccm.812011st.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsWork-exacerbated asthmaWork-related symptomsClinical characteristicsOccupational asthmaOfficial American Thoracic Society StatementAmerican Thoracic Society StatementWorsening of asthmaOnset of asthmaStandard medical managementMedical managementAdverse outcomesDescriptive epidemiologyOA casesRisk factorsAdverse socioeconomic outcomesCase definitionOccupational exposureSociety statementMedian prevalenceAsthmaWork exposurePreventive interventionsMedical careMedical literatureSystematic search
2010
Skin Exposure and Asthma
Redlich CA. Skin Exposure and Asthma. Annals Of The American Thoracic Society 2010, 7: 134-137. PMID: 20427586, PMCID: PMC3266020, DOI: 10.1513/pats.201002-025rm.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSkin exposureSite of sensitizationSubsequent inhalation challengeAsthma risk factorsImpair skin barrier functionFilaggrin gene mutationsSkin barrier functionAllergen entryAsthmatic responseInhalation challengeSubsequent asthmaAsthma developmentRisk factorsRespiratory tractHuman skin exposureAsthma riskSkin traumaAnimal studiesEpidemiology studiesBarrier functionEnvironmental exposuresGene mutationsProtein allergensSensitizationExposure assessment
2008
Diagnosis and Management of Work-Related Asthma American College of Chest Physicians Consensus Statement
Tarlo SM, Balmes J, Balkissoon R, Beach J, Beckett W, Bernstein D, Blanc PD, Brooks SM, Cowl CT, Daroowalla F, Harber P, Lemiere C, Liss GM, Pacheco KA, Redlich CA, Rowe B, Heitzer J. Diagnosis and Management of Work-Related Asthma American College of Chest Physicians Consensus Statement. CHEST Journal 2008, 134: 1s-41s. PMID: 18779187, DOI: 10.1378/chest.08-0201.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsWork-related asthmaWork-exacerbated asthmaChest Physicians consensus statementConsensus statementConsensus documentAmerican CollegeManagement of WRAChallenge testSpecific inhalation challenge testInhalation challenge testPreventive measuresMethacholine challenge testPeak flow recordingsCurrent consensus statementsOccupational medicine physiciansCareful occupational historyEffective preventive measuresOccupational asthmaImmunologic testsAppropriate investigationsSubstantial prevalenceEarly diagnosisMedicine physiciansOccupational historyAsthmaLung/skin connections in occupational lung disease
Redlich CA, Herrick CA. Lung/skin connections in occupational lung disease. Current Opinion In Allergy And Clinical Immunology 2008, 8: 115-119. PMID: 18317018, DOI: 10.1097/aci.0b013e3282f85a31.Peer-Reviewed Original ResearchConceptsOccupational lung diseaseLung diseaseChronic beryllium diseaseSkin exposureIsocyanate asthmaBeryllium diseaseSite of sensitizationSubsequent inhalation challengeEnvironmental lung diseaseLimited clinical studiesImpair skin barrier functionSkin barrier functionAsthmatic responseInhalation challengeRespiratory tractHuman skin exposureClinical studiesInhalation exposureRecent studiesAnimal studiesAirborne exposureDiseaseBarrier functionPersonal protective clothingProtein allergens
2007
Cost‐Effectiveness of Various Diagnostic Approaches for Occupational Asthma
Kennedy WA, Girard F, Chaboillez S, Cartier A, Côté J, Hargreave F, Labrecque M, Malo JL, Tarlo SM, Redlich CA, Lemière C. Cost‐Effectiveness of Various Diagnostic Approaches for Occupational Asthma. Canadian Respiratory Journal 2007, 14: 276-280. PMID: 17703242, PMCID: PMC2676393, DOI: 10.1155/2007/206519.Peer-Reviewed Original ResearchConceptsSpecific inhalation challengeOccupational asthmaSputum testingProbabilistic sensitivity analysesPEF monitoringDiagnosis of OASputum cell countsProportion of eosinophilsExpiratory flow monitoringAdditional correct diagnosisBase-case analysisInhalation challengeClinical outcomesOA patientsTreeAge ProClinical dataSerial measurementsCorrect diagnosisPatientsCanadian hospitalsCell countDiagnostic approachGold standardDiagnosisCost-effective alternative
2006
Skin Exposure to Isocyanates: Reasons for Concern
Bello D, Herrick CA, Smith TJ, Woskie SR, Streicher RP, Cullen MR, Liu Y, Redlich CA. Skin Exposure to Isocyanates: Reasons for Concern. Environmental Health Perspectives 2006, 115: 328-335. PMID: 17431479, PMCID: PMC1849909, DOI: 10.1289/ehp.9557.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSkin exposureIsocyanate asthmaSuch exposureAsthma-like responsesSubsequent inhalation challengeOccupational SafetyPersonal protective equipmentInhalation challengeOccupational asthmaSystemic sensitizationAsthmaInhalation exposureHealth AdministrationComputerized searchRespiratory exposureRelevant articlesProtective equipmentHuman literatureSkin absorptionSensitizationGoogle databasesNational InstituteLines of evidencePotential roleSufficient evidenceBiophysical determinants of toluene diisocyanate antigenicity associated with exposure and asthma
Ye YM, Kim CW, Kim HR, Kim HM, Suh CH, Nahm DH, Park HS, Redlich CA, Wisnewski AV. Biophysical determinants of toluene diisocyanate antigenicity associated with exposure and asthma. Journal Of Allergy And Clinical Immunology 2006, 118: 885-891. PMID: 17030242, DOI: 10.1016/j.jaci.2006.06.026.Peer-Reviewed Original Research
2005
Surveillance for isocyanate asthma: a model based cost effectiveness analysis
Wild DM, Redlich CA, Paltiel AD. Surveillance for isocyanate asthma: a model based cost effectiveness analysis. Occupational And Environmental Medicine 2005, 62: 743. PMID: 16234399, PMCID: PMC1740898, DOI: 10.1136/oem.2004.016147.Peer-Reviewed Original ResearchGlutathione protects human airway proteins and epithelial cells from isocyanates
Wisnewski AV, Liu Q, Liu J, Redlich CA. Glutathione protects human airway proteins and epithelial cells from isocyanates. Clinical & Experimental Allergy 2005, 35: 352-357. PMID: 15784115, DOI: 10.1111/j.1365-2222.2005.02185.x.Peer-Reviewed Original ResearchConceptsDose-dependent mannerAirway fluidGSH levelsHuman airway epithelial cellsVapor exposure systemEpithelial cellsHuman airway epithelial cell lineAirway epithelial cell lineEpithelial lining fluidAirway epithelial cellsEpithelial cell exposureEpithelial cell toxicityAllergic sensitizationEpithelial cell lineHDI exposureAirway proteinsLining fluidAirway cellsIsocyanate exposureVivo exposureOccupational limitsNCI-H292Physiologic levelsEpithelial fluidToxicity studies
2004
Polyisocyanates in occupational environments: A critical review of exposure limits and metrics
Bello D, Woskie SR, Streicher RP, Liu Y, Stowe MH, Eisen EA, Ellenbecker MJ, Sparer J, Youngs F, Cullen MR, Redlich CA. Polyisocyanates in occupational environments: A critical review of exposure limits and metrics. American Journal Of Industrial Medicine 2004, 46: 480-491. PMID: 15490474, DOI: 10.1002/ajim.20076.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIsocyanate vapor-induced antigenicity of human albumin
Wisnewski AV, Stowe MH, Cartier A, Liu Q, Liu J, Chen L, Redlich CA. Isocyanate vapor-induced antigenicity of human albumin. Journal Of Allergy And Clinical Immunology 2004, 113: 1178-1184. PMID: 15208602, DOI: 10.1016/j.jaci.2004.03.009.Peer-Reviewed Original ResearchConceptsHDI exposureHuman albuminAuto body shop workersHDI vaporHuman immune systemOccupational asthmaHumoral armSpecific IgEIgG titersHealthy workersImmune responseSerology studiesHuman airwaysImmune systemSignificant associationAntigenic formsShop workersAlbumin conjugatesAsthmaticsAsthmaIgEAntigenicityParallel studyAlbuminSignificant changes
2003
Human γ/δ T-cell proliferation and IFN-γ production induced by hexamethylene diisocyanate
Wisnewski AV, Herrick CA, Liu Q, Chen L, Bottomly K, Redlich CA. Human γ/δ T-cell proliferation and IFN-γ production induced by hexamethylene diisocyanate. Journal Of Allergy And Clinical Immunology 2003, 112: 538-546. PMID: 13679813, DOI: 10.1016/s0091-6749(03)01865-7.Peer-Reviewed Original ResearchConceptsGamma/delta T cellsDelta T cellsHuman immune responseT cellsT cell receptorImmune responseAlpha/beta T cell receptorBeta T cell receptorHuman airway epithelial cellsIFN-γ productionGamma/deltaT cell proliferationAirway epithelial cellsHuman T cell lineT cell linesHuman T cellsCell typesOccupational asthmaCytokine productionPeripheral bloodIL-13IL-5Antigen-mediated selectionAntigen leadIFN-gammaTruncating the Dose Range for Methacholine Challenge Tests: Three Occupational Studies
Agalliu I, Eisen EA, Hauser R, Redlich CA, Stowe MH, Cullen MR, Wegman DH, Christiani DC, Kennedy SM. Truncating the Dose Range for Methacholine Challenge Tests: Three Occupational Studies. Journal Of Occupational And Environmental Medicine 2003, 45: 841-847. PMID: 12915785, DOI: 10.1097/01.jom.0000083031.56116.53.Peer-Reviewed Original Research
2002
Diisocyanate‐exposed auto body shop workers: A one‐year follow‐up
Redlich CA, Stowe MH, Coren BA, Wisnewski AV, Holm CT, Cullen MR. Diisocyanate‐exposed auto body shop workers: A one‐year follow‐up. American Journal Of Industrial Medicine 2002, 42: 511-518. PMID: 12439874, DOI: 10.1002/ajim.10143.Peer-Reviewed Original ResearchConceptsHealthy worker effectAuto body shop workersWorker effectHexamethylene diisocyanate exposureHistory of asthmaLower asthma prevalenceCross-sectional studyDiisocyanate exposureOccupational asthmaAsthma prevalenceImmunologic responseLow prevalenceAsthmaOne-yearHigh job turnover ratesShop workersEpisodic exposureSignificant differencesAuto body shopsPrevalenceEffect of HDISignificant changesExposureSymptomsIgG