2002
Assessment of Antiangiogenic Effect Using 99mTc-EC-Endostatin
Yang DJ, Kim KD, Schechter NR, Yu DF, Wu P, Azhdarinia A, Roach JS, Kalimi SK, Ozaki K, Fogler WE, Bryant JL, Herbst R, Abbruzzes J, Kim EE, Podoloff DA. Assessment of Antiangiogenic Effect Using 99mTc-EC-Endostatin. Cancer Biotherapy & Radiopharmaceuticals 2002, 17: 233-246. PMID: 12030117, DOI: 10.1089/108497802753773856.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis InhibitorsAnimalsAntineoplastic Combined Chemotherapy ProtocolsApoptosisCollagenCysteineEndostatinsEndothelial Growth FactorsFemaleFibroblast Growth Factor 2In Situ Nick-End LabelingIntercellular Signaling Peptides and ProteinsInterleukin-8LymphokinesMammary Neoplasms, ExperimentalNeovascularization, PathologicPaclitaxelPeptide FragmentsRadionuclide ImagingRatsRats, Inbred F344TechnetiumTumor Cells, CulturedVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsTumor-bearing ratsAnti-angiogenesis therapyTreatment responseTumor uptakeTUNEL assayAnti-angiogenic treatment responseTumor vascular densityIL-8 expressionTumor-bearing animal modelsCount density ratiosCell viabilityPrognostic indicatorMicrovessel densityVascular densityAnimal modelsEndostatin therapyAntiangiogenic effectsMetastatic potentialTherapyUptake doseCellular uptake assaysEndostatinTissue distributionRatsEthylenedicysteine
1998
Potential of the aminosterol, squalamine in combination therapy in the rat 13,762 mammary carcinoma and the murine Lewis lung carcinoma.
Teicher BA, Williams JI, Takeuchi H, Ara G, Herbst RS, Buxton D. Potential of the aminosterol, squalamine in combination therapy in the rat 13,762 mammary carcinoma and the murine Lewis lung carcinoma. Anticancer Research 1998, 18: 2567-73. PMID: 9703911.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsAnticarcinogenic AgentsAntineoplastic AgentsCarcinoma, Lewis LungCell DivisionCholestanolsCisplatinCombined Modality TherapyCyclophosphamideDoxorubicinDrug Therapy, CombinationFemaleFluorouracilMammary Neoplasms, ExperimentalMiceOxygenOxygen ConsumptionPaclitaxelPartial PressureRatsRats, Inbred F344ConceptsLewis lung carcinomaTumor growth delayPost-tumor implantationLung carcinomaGrowth delayLung metastasesTumor implantationMammary carcinomaTumor oxygenationDay 4Chemotherapeutic agentsPrimary Lewis lung tumorMurine Lewis lung carcinomaDaily subcutaneous injectionsLewis lung tumorTumor-bearing animalsModest effectCombination therapyContinuous infusionCytotoxic therapySystemic diseaseSubcutaneous injectionLung tumorsAntiangiogenic agentsHypoxic fraction
1997
PEG-hemoglobin: effects on tumor oxygenation and response to chemotherapy.
Teicher B, Ara G, Herbst R, Takeuchi H, Keyes S, Northey D. PEG-hemoglobin: effects on tumor oxygenation and response to chemotherapy. In Vivo 1997, 11: 301-11. PMID: 9292296.Peer-Reviewed Original ResearchConceptsPEG-hemoglobinTumor growth delayMammary carcinomaTumor cell killingSolid tumorsTumor oxygenationGrowth delayDose of chemotherapyEMT-6 murine mammary carcinomaBone marrow CFU-GMEfficacy of chemotherapyEMT-6 tumorsMurine mammary carcinomaTumor-bearing miceCFU-GM survivalMarrow CFU-GMCell killingOxygen delivery agentEMT-6 tumor-bearing miceChemotherapy administrationLung metastasesMultiple dosesSingle dosesChemotherapyCFU-GM
1991
Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and transthyretin gene expression among hepatoma cells.
Herbst RS, Nielsch U, Sladek F, Lai E, Babiss LE, Darnell JE. Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and transthyretin gene expression among hepatoma cells. The New Biologist 1991, 3: 289-96. PMID: 1878351.Peer-Reviewed Original ResearchMeSH KeywordsAlbuminsAnimalsBase SequenceCCAAT-Enhancer-Binding ProteinsDNADNA-Binding ProteinsGene Expression RegulationHepatocyte Nuclear Factor 1Hepatocyte Nuclear Factor 1-alphaHepatocyte Nuclear Factor 1-betaHepatocyte Nuclear Factor 3-alphaHepatocyte Nuclear Factor 3-betaHepatocyte Nuclear Factor 3-gammaHepatocyte Nuclear Factor 4LiverMolecular Sequence DataNuclear ProteinsOligonucleotidesPhosphoproteinsPrealbuminRatsRNA, MessengerTranscription FactorsTumor Cells, CulturedConceptsTranscription factorsHepatocyte-enriched transcription factorsDNA-binding proteinsTransthyretin gene expressionRegulation of genesDNA-binding activityRat hepatoma cell lineLevel of expressionTranscriptional activityGene expressionHepatoma cell lineDifferential regulationCellular concentrationGenesHepatoma cellsCell linesExpressionRegulationTransthyretin geneLFB1HNF4HNF3ProteinEBPDifferent rates
1990
The mouse albumin enhancer contains a negative regulatory element that interacts with a novel DNA-binding protein.
Herbst RS, Boczko EM, Darnell JE, Babiss LE. The mouse albumin enhancer contains a negative regulatory element that interacts with a novel DNA-binding protein. Molecular And Cellular Biology 1990, 10: 3896-3905. PMID: 2370857, PMCID: PMC360900, DOI: 10.1128/mcb.10.8.3896.Peer-Reviewed Original ResearchConceptsDNA-binding sitesMouse albumin enhancerNovel DNA-binding proteinAlbumin enhancerNegative regulatory domainDNA-binding proteinsNegative regulatory regionDNA-binding activityNegative regulatory elementPositive-acting elementsOrientation-independent fashionRegulatory domainRegulatory regionsAlbumin gene transcriptionGene transcriptionRegulatory elementsEnhancer functionNew proteinsCap siteTissue specificityAlbumin geneCell typesProteinNonhepatic cellsEnhancerCis effect of the type 5 adenovirus E1A gene enhancer element on cellular transformation
Herbst R, Pelletier M, Babiss L. Cis effect of the type 5 adenovirus E1A gene enhancer element on cellular transformation. Journal Of Cellular Biochemistry 1990, 42: 33-44. PMID: 2137130, DOI: 10.1002/jcb.240420104.Peer-Reviewed Original ResearchConceptsCREF cellsViral DNA replicationDNA replicationWild-type virusEnhancer elementsGene enhancer elementsRodent embryo fibroblastsCis effectViral DNA integrationE1A gene expressionE1A mRNAsCytoplasmic mRNA levelsE1B mRNAsDNA template concentrationCellular transformationGene expressionDNA integrationViral E1AEmbryo fibroblastsType 5 adenovirusMutant virusMRNA levelsMRNACellsMRNA concentrations
1988
Regulation of adenovirus and cellular gene expression and of cellular transformation by the E1B-encoded 175-amino-acid protein
Herbst RS, Hermo H, Fisher PB, Babiss LE. Regulation of adenovirus and cellular gene expression and of cellular transformation by the E1B-encoded 175-amino-acid protein. Journal Of Virology 1988, 62: 4634-4643. PMID: 2972843, PMCID: PMC253576, DOI: 10.1128/jvi.62.12.4634-4643.1988.Peer-Reviewed Original ResearchConceptsE1A 289R proteinViral early gene expressionCellular gene expressionGene expressionE1A proteinsEarly gene expressionRat embryo fibroblast cellsEnhancer-dependent transcriptionViral E1A proteinsE1A gene productsAltered cell growthEmbryo fibroblast cellsTranscription initiationProtein functionCommon pathwayCellular transformationCREF cellsE1A 13SGene productsGene promoterFoci formationViral genomeHeLa cellsCell growthType 5 adenovirus
1987
Factors that interact with the rat albumin promoter are present both in hepatocytes and other cell types.
Babiss LE, Herbst RS, Bennett AL, Darnell JE. Factors that interact with the rat albumin promoter are present both in hepatocytes and other cell types. Genes & Development 1987, 1: 256-267. PMID: 3678823, DOI: 10.1101/gad.1.3.256.Peer-Reviewed Original Research
1984
Tyrosine hydroxylase-immunoreactive neurons of the hypothalamus: A light and electron microscopic study
van den Pol AN, Herbst RS, Powell JF. Tyrosine hydroxylase-immunoreactive neurons of the hypothalamus: A light and electron microscopic study. Neuroscience 1984, 13: 1117-1156. PMID: 6152034, DOI: 10.1016/0306-4522(84)90292-6.Peer-Reviewed Original ResearchConceptsImmunoreactive cellsCell groupsAdjacent cell groupsHypothalamic groupParaventricular nucleusDendritic arborsTyrosine hydroxylaseTyrosine hydroxylase-immunoreactive neuronsTyrosine hydroxylase-like immunoreactivityImmunoreactive cell groupsLarge immunoreactive cellsVentral lateral hypothalamusHydroxylase-immunoreactive neuronsTyrosine hydroxylase immunoreactivityHydroxylase-like immunoreactivityPosterior hypothalamic regionMorphology of neuronsMicrons coronal sectionsImmunoreactive groupsSomatic appendagesDendritic overlapHydroxylase immunoreactivityVentromedial nucleusAnterior hypothalamusLateral hypothalamus