2024
Survivorship care for people affected by advanced or metastatic cancer: MASCC-ASCO standards and practice recommendations
Hart N, Nekhlyudov L, Smith T, Yee J, Fitch M, Crawford G, Koczwara B, Ashbury F, Lustberg M, Mollica M, Smith A, Jefford M, Chino F, Zon R, Agar M, Chan R. Survivorship care for people affected by advanced or metastatic cancer: MASCC-ASCO standards and practice recommendations. Supportive Care In Cancer 2024, 32: 313. PMID: 38679639, PMCID: PMC11056340, DOI: 10.1007/s00520-024-08465-8.Peer-Reviewed Original ResearchConceptsQuality survivorship careSurvivorship carePractice recommendationsUnmet supportive care needsPalliative care frameworkSupportive care needsSystematic reviewModified Delphi consensus processEnd-of-lifeResultsA systematic reviewDelphi consensus processMethodsAn expert panelCancer survivorshipCare goalsCancer careCare experiencesCare needsCare frameworkHealth outcomesASCO membersConsensus processCareDelphi studyExpert panelMetastatic cancerEyebrow and Eyelash Loss in Patients With Cancer.
Rose L, Khuhro A, Minta A, Novice M, Novice T, Lustberg M, Ruddy K, Rake E, Loprinzi C, Dulmage B. Eyebrow and Eyelash Loss in Patients With Cancer. Journal Of Drugs In Dermatology 2024, 23: 327-331. PMID: 38709698, DOI: 10.36849/jdd.8003.Peer-Reviewed Original ResearchConceptsPrevention optionsRadiation therapyTopical vasoconstrictorEndocrine therapyEyelash lossTreatment optionsPrescription medicationsCancer treatmentPatientsScalp coolingHair lossRobust researchMadarosisPermanent tattoosTherapyCancerTreatmentEyebrowsEyelash hairScalpOptionsChemotherapyCryotherapyVasoconstrictorDermatologists
2023
Patient perceptions of altering chemotherapy treatment due to peripheral neuropathy
Hertz D, Tofthagen C, Rossi E, Bernasconi D, Lim J, Carlson M, Sheffield K, Nekhlyudov L, Grech L, Von Ah D, Mayo S, Ruddy K, Chan A, Alberti P, Lustberg M, Tanay M. Patient perceptions of altering chemotherapy treatment due to peripheral neuropathy. Supportive Care In Cancer 2023, 32: 48. PMID: 38129602, DOI: 10.1007/s00520-023-08209-0.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyNeurotoxic chemotherapy treatmentChemotherapy treatmentSymptom resolutionPeripheral neuropathySevere chemotherapy-induced peripheral neuropathyCommon reason participantsMethodsA cross-sectional online surveyBetter patient educationCross-sectional online surveyNeurotoxic chemotherapyCIPN symptomsMedian ageMost patientsTreating clinicianLong-term benefitsPatients' perceptionsPatient educationPractice guidelinesTreatment goalsClinicians' understandingTreatment efficacyConclusionsThis surveyPatientsSymptomsEvolution of predictive risk factor analysis for chemotherapy-related toxicity
Hertz D, Lustberg M, Sonis S. Evolution of predictive risk factor analysis for chemotherapy-related toxicity. Supportive Care In Cancer 2023, 31: 601. PMID: 37773300, DOI: 10.1007/s00520-023-08074-x.Peer-Reviewed Original ResearchConceptsTreatment-related toxicityBiomarker discovery approachClinical practiceTaxane-induced peripheral neuropathyChemotherapy-related toxicitySame treatment regimenMaximum treatment benefitRisk factor analysisPrecision oncology treatmentsToxicity riskPeripheral neuropathyTreatment regimenSimilar patientsToxicity predictorsTreatment benefitPharmacogenetic predictorsOncology treatmentSide effectsTherapeutic outcomesCancer treatmentMinimal toxicityIntegrated biomarkersGermline genomicsBiomarker sciencePatientsAdolescent and Young Adult (AYA) Oncology, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology.
Bhatia S, Pappo A, Acquazzino M, Allen-Rhoades W, Barnett M, Borinstein S, Casey R, Choo S, Chugh R, Dinner S, Ermoian R, Fair D, Federman N, Folbrecht J, Gandhi S, Germann J, Goldsby R, Hayashi R, Huang A, Huang M, Jacobs L, Lee-Miller C, Link M, Livingston J, Lustberg M, Malogolowkin M, Oeffinger K, Pratilas C, Reed D, Skiles J, von Mehren M, Yeager N, Montgomery S, Hang L. Adolescent and Young Adult (AYA) Oncology, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network 2023, 21: 851-880. PMID: 37549914, DOI: 10.6004/jnccn.2023.0040.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAgedCounselingHumansMedical OncologyNeoplasmsRisk FactorsSurvivorshipYoung AdultConceptsYoung Adult OncologyAYA patientsAdult oncologyNCCN guidelinesNCCN Clinical Practice GuidelinesClinical practice guidelinesSupportive care servicesFertility counselingRisk factorsComprehensive carePractice guidelinesCare servicesPatientsOlder adultsOncologyCancerUnique needsGuidelinesAdolescentsBehavioral issuesDiagnosisCareFemale reproductive health in pediatric, adolescent, and young adult cancer survivors
Hoefgen H, Benoit J, Chan S, Jayasinghe Y, Lustberg M, Pohl V, Saraf A, Schmidt D, Appiah L. Female reproductive health in pediatric, adolescent, and young adult cancer survivors. Pediatric Blood & Cancer 2023, 70: e29170. PMID: 37381166, DOI: 10.1002/pbc.29170.Peer-Reviewed Original ResearchConceptsQuality of lifeGenital graftHost diseaseCancer survivorsLate effectsReproductive healthHematopoietic stem cell transplantCancer treatmentYoung adult cancer survivorsHormone replacement therapyCervical cancer screeningStem cell transplantFemale reproductive healthAdult cancer survivorsLarge cohort studyLikelihood of pregnancyYoung Adult Cancer SurvivorshipAdult cancer survivorshipGynecologic outcomesVaginal injuryCohort studyCell transplantReplacement therapyCancer careCancer screeningMitigating long-term and delayed adverse events associated with cancer treatment: implications for survivorship
Lustberg M, Kuderer N, Desai A, Bergerot C, Lyman G. Mitigating long-term and delayed adverse events associated with cancer treatment: implications for survivorship. Nature Reviews Clinical Oncology 2023, 20: 527-542. PMID: 37231127, PMCID: PMC10211308, DOI: 10.1038/s41571-023-00776-9.Peer-Reviewed Original ResearchConceptsAdverse eventsEvidence-based clinical practice guidelinesChemotherapy-associated adverse eventsNon-pharmacological treatment strategiesAdverse effectsClinical practice guidelinesAdverse treatment effectsCourse of therapyTotality of evidenceQuality of lifeTerms of survivalRisk assessment toolOptimal therapyCancer survivorsRisk factorsOncology practiceTreatment strategiesPractice guidelinesUnderlying biological mechanismsAppropriate managementAnticancer treatmentCancer treatmentEffective interventionsTreatment effectsChemotherapyLeveraging GWAS data derived from a large cooperative group trial to assess the risk of taxane-induced peripheral neuropathy (TIPN) in patients being treated for breast cancer: Part 2—functional implications of a SNP cluster associated with TIPN risk in patients being treated for breast cancer
Lustberg M, Wu X, Fernández-Martínez J, de Andrés-Galiana E, Philips S, Leibowitz J, Schneider B, Sonis S. Leveraging GWAS data derived from a large cooperative group trial to assess the risk of taxane-induced peripheral neuropathy (TIPN) in patients being treated for breast cancer: Part 2—functional implications of a SNP cluster associated with TIPN risk in patients being treated for breast cancer. Supportive Care In Cancer 2023, 31: 178. PMID: 36809570, PMCID: PMC11344472, DOI: 10.1007/s00520-023-07617-6.Peer-Reviewed Original ResearchConceptsGWAS dataSNP clustersFunctional analysisGO termsNon-protein coding genesGene Ontology termsGene Set Enrichment AnalysisCluster of SNPsNervous system developmentCoding genesRetinoic acid bindingOntology termsProtein kinase C bindingEnrichment analysisMetabolic processesGenesAcid bindingGlycosyltransferase activitySNPsPathological implicationsGWASC bindingGene signaturePhenotypeTransferase activityThe Rise of Supportive Oncology: A Revolution in Cancer Care
Berman R, Laird B, Minton O, Monnery D, Ahamed A, Boland E, Droney J, Vidrine J, Leach C, Scotté F, Lustberg M, Lacey J, Chan R, Duffy T, Noble S. The Rise of Supportive Oncology: A Revolution in Cancer Care. Clinical Oncology 2023, 35: 213-215. PMID: 36737312, DOI: 10.1016/j.clon.2023.01.015.Peer-Reviewed Original Research
2021
Financial Burden of Drugs Prescribed for Cancer-Associated Symptoms
Gupta A, Nshuti L, Grewal US, Sedhom R, Check DK, Parsons HM, Blaes AH, Virnig BA, Lustberg MB, Subbiah IM, Nipp RD, Dy SM, Dusetzina SB. Financial Burden of Drugs Prescribed for Cancer-Associated Symptoms. JCO Oncology Practice 2021, 18: 140-147. PMID: 34558297, PMCID: PMC9213200, DOI: 10.1200/op.21.00466.Peer-Reviewed Original ResearchConceptsCancer-associated symptomsChemotherapy-induced peripheral neuropathyCancer-associated fatigueSymptom control drugsPatient-clinician discussionsExocrine pancreatic insufficiencyCost of drugsBrand-name formulationProphylaxis regimenPeripheral neuropathyDrug prescribedPancreatic insufficiencyNew agentsControl drugSame drugFinancial toxicitySymptomsDrugsFinancial burdenRelevant guidelinesAnticancer drugsPerspectives of adolescent and young adult cancer survivors: review of community-based discussion boards
Smith A, Fogarasi M, Lustberg MB, Nekhlyudov L. Perspectives of adolescent and young adult cancer survivors: review of community-based discussion boards. Journal Of Cancer Survivorship 2021, 16: 1079-1089. PMID: 34471949, DOI: 10.1007/s11764-021-01098-4.Peer-Reviewed Original ResearchConceptsYoung adult cancer survivorsAYA cancer survivorsAdult cancer survivorsAYA survivorsCancer survivorsFamily/friendsPatient populationMethodsUsing qualitative methodsYoung cancer survivorsNon-family relationshipsPsychological challengesHealthcare delivery domainsAmerican Cancer Society Cancer Survivors NetworkSurvivors' concernsPsychosocial concernsPsychosocial effectsCancer survivorsInterventionsMultiple domainsCancer Survivors NetworkPsychosocial issuesInterpersonal topicsSurvivors NetworkMajority of postsNew cancersCare coordinationFuture research in cancer survivorship
Chan RJ, Nekhlyudov L, Duijts SFA, Hudson SV, Jones JM, Keogh J, Love B, Lustberg MB, Mehnert-Theuerkauf A, Nathan P, Ness KK, Sheppard VB, Smith K, Tevaarwerk A, Yu X, Feuerstein M. Future research in cancer survivorship. Journal Of Cancer Survivorship 2021, 15: 659-667. PMID: 34460055, DOI: 10.1007/s11764-021-01102-x.Peer-Reviewed Original ResearchExamining the Association of Billed Advance Care Planning With End-of-Life Hospital Admissions Among Advanced Cancer Patients in Hospice
Prater LC, O’Rourke B, Schnell P, Xu W, Li Y, Gustin J, Lockwood B, Lustberg M, White S, Happ MB, Retchin SM, Wickizer TM, Bose-Brill S. Examining the Association of Billed Advance Care Planning With End-of-Life Hospital Admissions Among Advanced Cancer Patients in Hospice. American Journal Of Hospice And Palliative Medicine® 2021, 39: 504-510. PMID: 34427154, DOI: 10.1177/10499091211039449.Peer-Reviewed Original ResearchConceptsAdvance care planningDays of lifeHospital admissionAdvanced cancerCare planningACP servicesCross-sectional retrospective cohort studySystematic advance care planningLife hospital admissionsMedical claims analysisRetrospective cohort studyAdvanced cancer patientsInpatient hospital admissionsPopulation of patientsAdvanced cancer diagnosisQuality of careHospice referralCohort studyIBM MarketScanEOL outcomesInpatient admissionsStudy criteriaCancer patientsHospice careCare preferencesPatient-centric decision framework for treatment alterations in patients with Chemotherapy-induced Peripheral Neuropathy (CIPN)
Hertz DL, Childs DS, Park SB, Faithfull S, Ke Y, Ali NT, McGlown SM, Chan A, Grech LB, Loprinzi CL, Ruddy KJ, Lustberg M. Patient-centric decision framework for treatment alterations in patients with Chemotherapy-induced Peripheral Neuropathy (CIPN). Cancer Treatment Reviews 2021, 99: 102241. PMID: 34174668, DOI: 10.1016/j.ctrv.2021.102241.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyNeurotoxic chemotherapy treatmentTreatment alterationsCIPN severityPeripheral neuropathyPatient factorsChemotherapy treatmentRelative dose intensityClinical Oncology guidelinesNeurotoxic chemotherapyDose intensityProspective trialOncology guidelinesRetrospective analysisAdult cancersIndividual patientsInconsistent recommendationsPatientsTreatment efficacyClinical decisionSeverityNeuropathyAmerican SocietyTreatmentCliniciansSupportive Care: Low Cost, High Value.
Popescu RA, Roila F, Arends J, Metro G, Lustberg M. Supportive Care: Low Cost, High Value. American Society Of Clinical Oncology Educational Book 2021, 41: 1-11. PMID: 33830830, DOI: 10.1200/edbk_320041.Peer-Reviewed Original ResearchConceptsQuality of lifePhysical exerciseChemotherapy-induced peripheral neuropathyLarge phase III trialsElectronic patient-reported outcome measuresPatient-reported outcome measuresPersonalization of chemotherapySupportive care unitPhase III trialsSupportive care interventionsCancer-related fatigueMind-body interventionsNonpharmacologic strategiesScrambler therapyGastrointestinal dysmotilityIII trialsOverall survivalSupportive careTreatable causeMuscle trainingPeripheral neuropathyCare unitClinic appointmentsMetabolic derangementsRegular screeningIntroduction to special section: Living with Incurable Cancer: Addressing Gaps in Cancer Survivorship
Lustberg MB, Carlson M, Nekhlyudov L. Introduction to special section: Living with Incurable Cancer: Addressing Gaps in Cancer Survivorship. Journal Of Cancer Survivorship 2021, 15: 367-369. PMID: 33945110, DOI: 10.1007/s11764-021-01047-1.Peer-Reviewed Original ResearchDeveloping a global cancer survivorship community: the Journal of Cancer Survivorship Social Media Site @jcansurv
Lustberg MB, Nekhlyudov L, Jones JM, Love B, Katz MS, Feuerstein M. Developing a global cancer survivorship community: the Journal of Cancer Survivorship Social Media Site @jcansurv. Journal Of Cancer Survivorship 2021, 15: 481-484. PMID: 33788171, PMCID: PMC8011364, DOI: 10.1007/s11764-021-01034-6.Peer-Reviewed Original ResearchTargeting OCT3 attenuates doxorubicin-induced cardiac injury
Huang KM, Thomas M, Magdy T, Eisenmann ED, Uddin ME, DiGiacomo DF, Pan A, Keiser M, Otter M, Xia SH, Li Y, Jin Y, Fu Q, Gibson AA, Bonilla IM, Carnes CA, Corps KN, Coppola V, Smith SA, Addison D, Nies AT, Bundschuh R, Chen T, Lustberg MB, Wang J, Oswald S, Campbell MJ, Yan PS, Baker SD, Hu S, Burridge PW, Sparreboom A. Targeting OCT3 attenuates doxorubicin-induced cardiac injury. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2020168118. PMID: 33495337, PMCID: PMC7865186, DOI: 10.1073/pnas.2020168118.Peer-Reviewed Original ResearchConceptsOrganic cation transporter 3Cardiac injuryCardiovascular functionSide effectsTranslational relevanceCalcium-binding proteins S100A8Irreversible cardiac injuryCurrent preventative strategiesPotential translational relevanceCardiac damagePlasma levelsCardiac accumulationBreast cancerAntitumor effectsPharmacological targetingPreventative strategiesModest protectionProteins S100A8Critical transporterTransporter 3Pharmacological inhibitorsOverexpression modelIntervention strategiesDoxorubicinCardiotoxicityDissemination of cancer survivorship care plans: who is being left out?
Timsina LR, Zarzaur B, Haggstrom DA, Jenkins PC, Lustberg M, Obeng-Gyasi S. Dissemination of cancer survivorship care plans: who is being left out? Supportive Care In Cancer 2021, 29: 4295-4302. PMID: 33415363, DOI: 10.1007/s00520-020-05915-x.Peer-Reviewed Original ResearchConceptsSurvivorship care plansCancer survivorsCare plansComprehensive survivorship care planCancer survivorship care plansLow educational achievementMultivariable logistic regressionSelf-reported receiptQuality of careAssociation of SDOHYounger patientsSurgeons CommissionCancer patientsPrimary careAmerican CollegeAdult populationSocial determinantsLogistic regressionPatientsSurvivorsLower likelihoodMarital statusCareFuture studiesReceipt
2020
Readdressing the Needs of Cancer Survivors During COVID-19: A Path Forward
Jones JM, Saeed H, Katz MS, Lustberg MB, Forster VJ, Nekhlyudov L. Readdressing the Needs of Cancer Survivors During COVID-19: A Path Forward. Journal Of The National Cancer Institute 2020, 113: 955-961. PMID: 33367655, PMCID: PMC7799033, DOI: 10.1093/jnci/djaa200.Peer-Reviewed Original ResearchConceptsCancer survivorsCancer survivorship careCoronavirus disease 2019 (COVID-19) pandemicHealth care needsDisease 2019 pandemicHealth care systemSurvivorship careCOVID-19 waveHigh prevalenceCare needsHealth systemPsychosocial effectsCare systemSurvivorsCOVID-19Further stressorsPandemicPrevalenceCare