2023
Prognosis and risk of suicide after cancer diagnosis
Kinslow C, Kumar P, Olfson M, Wall M, Petridis P, Horowitz D, Wang T, Kachnic L, Cheng S, Prigerson H, Yu J, Neugut A. Prognosis and risk of suicide after cancer diagnosis. Cancer 2023, 130: 588-596. PMID: 38018695, DOI: 10.1002/cncr.35118.Peer-Reviewed Original ResearchConceptsRisk of suicideCancer diagnosisSuicide riskCancer sitesMonths of diagnosisRelative risk of suicideSuicide deathsBaseline suicide riskSuicide ratesNewly diagnosed cancerYears of follow-upImpact of prognosisExistential distressAssociated with suicide riskMortality ratioWeighted linear regression modelImpending deathLinear regression modelsUS populationRelative riskGeneral populationBaseline riskAssociated with overall prognosisEnd Results databaseOverall survival rateRisk of Squamous Cell Carcinoma of the Breast Following Postmastectomy Implant Reconstruction in Women With Breast Cancer and Carcinoma in Situ
Kinslow C, Yu J, DeStephano D, Kachnic L, Cheng S, Neugut A, Horowitz D. Risk of Squamous Cell Carcinoma of the Breast Following Postmastectomy Implant Reconstruction in Women With Breast Cancer and Carcinoma in Situ. JAMA Surgery 2023, 158: 769-771. PMID: 37074722, PMCID: PMC10116379, DOI: 10.1001/jamasurg.2023.0262.Peer-Reviewed Original Research
2022
Association between social connectedness and stress or anxiety among older cancer survivors during the 2020–2021 winter surge of the COVID-19 pandemic
Poghosyan H, Margaryan Y, Jeon S, Edelman EJ, Yu JB. Association between social connectedness and stress or anxiety among older cancer survivors during the 2020–2021 winter surge of the COVID-19 pandemic. Journal Of Geriatric Oncology 2022, 14: 101390. PMID: 36274031, PMCID: PMC9554341, DOI: 10.1016/j.jgo.2022.10.005.Peer-Reviewed Original Research
2021
Post-operative radiation therapy for non-small cell lung cancer: A comparison of radiation therapy techniques
Jairam V, Pasha S, Soulos PR, Gross CP, Yu JB, Park HS, Decker RH. Post-operative radiation therapy for non-small cell lung cancer: A comparison of radiation therapy techniques. Lung Cancer 2021, 161: 171-179. PMID: 34607209, DOI: 10.1016/j.lungcan.2021.09.010.Peer-Reviewed Original ResearchConceptsPost-operative radiation therapyNon-small cell lung cancerCell lung cancerRadiation therapyPropensity-score matchingLA-NSCLCCardiac toxicityLung cancerAdvanced non-small cell lung cancerClinical risk factorsProportion of patientsMultivariable logistic regressionPrior treatment historyPredictors of receiptUse of IMRTConformal radiation therapyLong-term toxicityChi-squared testRadiation therapy techniquesRadiotherapy treatment techniquesUpfront surgeryElderly patientsTreatment toxicityMean ageMedicare databaseOutcomes of Stereotactic Radiosurgery and Immunotherapy in Renal Cell Carcinoma Patients With Brain Metastases
Uezono H, Nam D, Kluger HM, Sznol M, Hurwitz M, Yu JB, Chiang VL. Outcomes of Stereotactic Radiosurgery and Immunotherapy in Renal Cell Carcinoma Patients With Brain Metastases. American Journal Of Clinical Oncology 2021, 44: 495-501. PMID: 34432667, DOI: 10.1097/coc.0000000000000849.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsRCC brain metastasesBrain metastasesRenal cell carcinomaStereotactic radiosurgeryOverall survivalUse of ICIsCentral nervous system toxicityRenal cell carcinoma patientsImpact of immunotherapyLocal control outcomesMedian overall survivalCell carcinoma patientsKaplan-Meier curvesNervous system toxicityBetter median OSLog-rank testMann-Whitney U testMargin doseMedian OSNonimmunotherapy groupSRS doseCheckpoint inhibitorsImmunotherapy groupCarcinoma patientsCost-Effectiveness of Adjuvant Treatment for Ductal Carcinoma In Situ
Gupta A, Jhawar SR, Sayan M, Yehia ZA, Haffty BG, Yu JB, Wang SY. Cost-Effectiveness of Adjuvant Treatment for Ductal Carcinoma In Situ. Journal Of Clinical Oncology 2021, 39: 2386-2396. PMID: 34019456, PMCID: PMC10166354, DOI: 10.1200/jco.21.00831.Peer-Reviewed Original ResearchConceptsAromatase inhibitorsTreatment strategiesRadiation treatmentDuctal carcinomaAge 40Risk reductionAdjuvant treatment strategiesGood-risk patientsLarge randomized trialsAdverse event ratesOptimal treatment strategyRelative risk reductionCohort of womenBreast cancer casesLow-value careQuality of lifeCost-effectiveness analysisBase-case resultsHormonal therapyAdjuvant treatmentMost patientsPatient ageSecondary malignanciesRandomized trialsRecurrence rateSystematic review and meta-analysis of radiation therapy for high-risk non-muscle invasive bladder cancer
Rodrigues Pessoa R, Mueller A, Boxley P, Flaig T, Piper C, Konety B, Yu J, Gershman B, Kukreja J, Kim S. Systematic review and meta-analysis of radiation therapy for high-risk non-muscle invasive bladder cancer. Urologic Oncology Seminars And Original Investigations 2021, 39: 786.e1-786.e8. PMID: 33846085, DOI: 10.1016/j.urolonc.2021.03.009.Peer-Reviewed Original ResearchConceptsHigh-risk non-muscle invasive bladder cancerNon-muscle invasive bladder cancerCancer specific-survivalRecurrence-free survivalInvasive bladder cancerBacillus Calmette-GuerinOverall survivalRadiation therapyBladder cancerMeta-analysisRates of recurrence-free survivalClinical trialsGoal of bladder preservationMetastatic disease rateSalvage radical cystectomyCochrane Central Register of Controlled TrialsProspective clinical trialCentral Register of Controlled TrialsTreatment of patientsRegister of Controlled TrialsSystematic reviewCochrane Central RegisterLow-quality evidenceQuality of evidenceBladder preservationPrevalence of Missing Data in the National Cancer Database and Association With Overall Survival
Yang DX, Khera R, Miccio JA, Jairam V, Chang E, Yu JB, Park HS, Krumholz HM, Aneja S. Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival. JAMA Network Open 2021, 4: e211793. PMID: 33755165, PMCID: PMC7988369, DOI: 10.1001/jamanetworkopen.2021.1793.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseNon-small cell lung cancerOverall survivalCell lung cancerCancer DatabaseMedical recordsLung cancerProstate cancerBreast cancerPatient recordsComplete dataRetrospective cohort studyCohort studyCancer RegistryCommon cancerVariables of interestHigh prevalenceMAIN OUTCOMEPatientsClinical advancementReal-world data sourcesCancerPrevalenceSurvivalHeterogeneous differences
2020
Physician trajectories of abandoning long‐course breast radiotherapy and their cost impact
Xu X, Soulos PR, Herrin J, Wang S, Pollack CE, Evans SB, Yu JB, Gross CP. Physician trajectories of abandoning long‐course breast radiotherapy and their cost impact. Health Services Research 2020, 56: 497-506. PMID: 33070305, PMCID: PMC8143683, DOI: 10.1111/1475-6773.13572.Peer-Reviewed Original ResearchConceptsPhysician peer groupsWhole breast irradiationCF-WBIRisk-adjusted ratesBreast radiotherapyPractice patternsLow useChronic Conditions Data WarehouseDistinct practice patternsPatients' clinical characteristicsSetting of radiotherapyAdjuvant breast radiotherapyYears of ageDistinct trajectoriesImportant cost implicationsHigher useAdjuvant radiotherapyClinical characteristicsEligible womenBreast cancerCost implicationsLatent class growth analysisService beneficiariesMedicare programRadiotherapyTemporal Trends in Opioid Prescribing Patterns Among Oncologists in the Medicare Population
Jairam V, Yang DX, Pasha S, Soulos PR, Gross CP, Yu JB, Park HS. Temporal Trends in Opioid Prescribing Patterns Among Oncologists in the Medicare Population. Journal Of The National Cancer Institute 2020, 113: 274-281. PMID: 32785685, PMCID: PMC7936059, DOI: 10.1093/jnci/djaa110.Peer-Reviewed Original ResearchConceptsOpioid-prescribing ratesOpioid prescribingOpioid Prescribing PatternsOpioid-prescribing guidelinesUS opioid epidemicPalliative care providersMultivariable negative binomial regressionNoncancer populationsPrescribing patternsPrescribing ratesSymptom managementCancer survivorsOpioid epidemicDrug claimsCare providersMedicare populationMedicare beneficiariesPrescribingOncologistsNononcologistsNegative binomial regressionOpioidsBinomial regressionPatientsAnnual numberNational Patterns in Prescription Opioid Use and Misuse Among Cancer Survivors in the United States
Jairam V, Yang DX, Verma V, Yu JB, Park HS. National Patterns in Prescription Opioid Use and Misuse Among Cancer Survivors in the United States. JAMA Network Open 2020, 3: e2013605. PMID: 32804217, PMCID: PMC7431994, DOI: 10.1001/jamanetworkopen.2020.13605.Peer-Reviewed Original ResearchConceptsPrescription opioid usePrescription opioid misuseRecent cancer survivorsOpioid useCancer survivorsAdult cancer survivorsOpioid misuseUse disordersHigher prescription opioid useRecent cancer historyCancer-related painHistory of cancerPopulation-based studyNonmelanoma skin cancerDrug use disordersCross-sectional studyAlcohol use disorderLong-term misusePrescription opioidsCancer historyMAIN OUTCOMESkin cancerDrug useYounger ageCancerNationwide Patterns of Pathologic Fractures Among Patients Hospitalized With Bone Metastases
Jairam V, Lee V, Yu JB, Park HS. Nationwide Patterns of Pathologic Fractures Among Patients Hospitalized With Bone Metastases. American Journal Of Clinical Oncology 2020, 43: 720-726. PMID: 32694296, DOI: 10.1097/coc.0000000000000737.Peer-Reviewed Original ResearchConceptsPathologic fractureBone metastasesMultiple myelomaUtilization Project National Inpatient SampleLonger inpatient staysMultivariable logistic regressionNational Inpatient SampleIntrahepatic bile ductsRenal pelvis cancerRenal cell carcinomaProphylactic stabilizationHospital admissionPrimary cancerBile ductInpatient stayPelvis cancerCell carcinomaInpatient SamplePrimary diagnosisRisk factorsBaseline differencesOutpatient monitoringHigh riskHealthcare costsPatientsEvaluation of First-line Radiosurgery vs Whole-Brain Radiotherapy for Small Cell Lung Cancer Brain Metastases
Rusthoven CG, Yamamoto M, Bernhardt D, Smith DE, Gao D, Serizawa T, Yomo S, Aiyama H, Higuchi Y, Shuto T, Akabane A, Sato Y, Niranjan A, Faramand AM, Lunsford LD, McInerney J, Tuanquin LC, Zacharia BE, Chiang V, Singh C, Yu JB, Braunstein S, Mathieu D, Touchette CJ, Lee CC, Yang HC, Aizer AA, Cagney DN, Chan MD, Kondziolka D, Bernstein K, Silverman JS, Grills IS, Siddiqui ZA, Yuan JC, Sheehan JP, Cordeiro D, Nosaki K, Seto T, Deibert CP, Verma V, Day S, Halasz LM, Warnick RE, Trifiletti DM, Palmer JD, Attia A, Li B, Cifarelli CP, Brown PD, Vargo JA, Combs SE, Kessel KA, Rieken S, Patel S, Guckenberger M, Andratschke N, Kavanagh BD, Robin TP. Evaluation of First-line Radiosurgery vs Whole-Brain Radiotherapy for Small Cell Lung Cancer Brain Metastases. JAMA Oncology 2020, 6: 1028-1037. PMID: 32496550, PMCID: PMC7273318, DOI: 10.1001/jamaoncol.2020.1271.Peer-Reviewed Original ResearchConceptsWhole brain radiotherapyProgression-free survivalSmall-cell lung cancer (SCLC) brain metastasesCell lung cancer brain metastasesCNS progression-free survivalLung cancer brain metastasesPropensity score-matched analysisMedian overall survivalCancer brain metastasesBrain metastasesOverall survivalStereotactic radiosurgeryCentral nervous system (CNS) progression-free survivalMedian CNS progression-free survivalSRS outcomesCentral nervous system progressionSmall cell lung cancerLimited brain metastasesMulticenter cohort studyDisease control statusCell lung cancerSingle-arm trialStandard of careLeptomeningeal progressionWBRT cohortNationwide patterns of hemorrhagic stroke among patients hospitalized with brain metastases: influence of primary cancer diagnosis and anticoagulation
Lee V, Jairam V, Yu JB, Park HS. Nationwide patterns of hemorrhagic stroke among patients hospitalized with brain metastases: influence of primary cancer diagnosis and anticoagulation. Scientific Reports 2020, 10: 10084. PMID: 32572113, PMCID: PMC7308286, DOI: 10.1038/s41598-020-67316-8.Peer-Reviewed Original ResearchConceptsBrain metastasesLong-term anticoagulationIntracerebral hemorrhageKidney cancerHigh riskUtilization Project Nationwide Inpatient SampleDiagnosis of ICHHospital-related characteristicsRisks of anticoagulationPrimary cancer diagnosisMultivariable logistic regressionNationwide Inpatient SampleLonger lengthDiagnosis of melanomaMann-Whitney UHemorrhagic strokeNeurologic dysfunctionConcurrent diagnosisSignificant morbiditySecondary diagnosisInpatient SampleBaseline differencesDecreased qualityAnticoagulationHealthcare costsPembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial
Goldberg SB, Schalper KA, Gettinger SN, Mahajan A, Herbst RS, Chiang AC, Lilenbaum R, Wilson FH, Omay SB, Yu JB, Jilaveanu L, Tran T, Pavlik K, Rowen E, Gerrish H, Komlo A, Gupta R, Wyatt H, Ribeiro M, Kluger Y, Zhou G, Wei W, Chiang VL, Kluger HM. Pembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial. The Lancet Oncology 2020, 21: 655-663. PMID: 32251621, PMCID: PMC7380514, DOI: 10.1016/s1470-2045(20)30111-x.Peer-Reviewed Original ResearchConceptsBrain metastasis responseYale Cancer CenterPD-L1 expressionPhase 2 trialUntreated brain metastasesBrain metastasesAdrenal insufficiencyAdverse eventsMetastasis responseCNS diseaseCancer CenterCohort 2Cohort 1Eastern Cooperative Oncology Group performance statusTreatment-related serious adverse eventsModified Response Evaluation CriteriaStage IV NSCLCTreatment-related deathsAcute kidney injuryPD-1 blockadeSerious adverse eventsSolid Tumors criteriaPhase 2 studyProportion of patientsResponse Evaluation CriteriaBeyond an Updated Graded Prognostic Assessment (Breast GPA): A Prognostic Index and Trends in Treatment and Survival in Breast Cancer Brain Metastases From 1985 to Today
Sperduto PW, Mesko S, Li J, Cagney D, Aizer A, Lin NU, Nesbit E, Kruser TJ, Chan J, Braunstein S, Lee J, Kirkpatrick JP, Breen W, Brown PD, Shi D, Shih HA, Soliman H, Sahgal A, Shanley R, Sperduto W, Lou E, Everett A, Boggs DH, Masucci L, Roberge D, Remick J, Plichta K, Buatti JM, Jain S, Gaspar LE, Wu CC, Wang TJC, Bryant J, Chuong M, Yu J, Chiang V, Nakano T, Aoyama H, Mehta MP. Beyond an Updated Graded Prognostic Assessment (Breast GPA): A Prognostic Index and Trends in Treatment and Survival in Breast Cancer Brain Metastases From 1985 to Today. International Journal Of Radiation Oncology • Biology • Physics 2020, 107: 334-343. PMID: 32084525, PMCID: PMC7276246, DOI: 10.1016/j.ijrobp.2020.01.051.Peer-Reviewed Original ResearchConceptsDiagnosis-specific prognostic factorsHuman epidermal receptor 2Prognostic factorsMedian survivalBreast-GPABrain metastasesBreast cancerCohort BCohort APrognostic indexReceptor 2Tumor subtypesBreast cancer brain metastasesKaplan-Meier survival estimatesCancer brain metastasesGraded Prognostic AssessmentKarnofsky performance statusLarge contemporary cohortLog-rank testFuture clinical trialsNew prognostic factorsGPA 0Extracranial metastasesPerformance statusBetter prognosisEmergency Department Visits for Firearm-Related Injuries among Youth in the United States, 2006–2015
Lee V, Camp C, Jairam V, Park HS, Yu JB. Emergency Department Visits for Firearm-Related Injuries among Youth in the United States, 2006–2015. The Journal Of Law, Medicine & Ethics 2020, 48: 67-73. PMID: 33404319, DOI: 10.1177/1073110520979403.Peer-Reviewed Original ResearchConceptsNationwide Emergency Department SampleEmergency department visitsFirearm injuriesDepartment visitsInjury dataSignificant public health problemEmergency Department SampleEmergency Department DatabasesPublic health problemFirearm-related injuriesPatient ageEmergency departmentRisk factorsDepartment databaseNumber of childrenSignificant burdenImmense burdenHealth problemsDeath dataInjuryVisitsUnited StatesBurdenDescriptive analysisSafety measures
2019
Early Impact of the Affordable Care Act and Medicaid Expansion on Racial and Socioeconomic Disparities in Cancer Care
Mahal A, Chavez J, Yang D, Kim D, Cole A, Hu J, Trinh Q, Yu J, Nguyen P, Mahal B. Early Impact of the Affordable Care Act and Medicaid Expansion on Racial and Socioeconomic Disparities in Cancer Care. American Journal Of Clinical Oncology 2019, 43: 163-167. PMID: 31904711, DOI: 10.1097/coc.0000000000000588.Peer-Reviewed Original ResearchConceptsAffordable Care ActAffordable Care Act implementationMedicaid expansionUninsured rateCare ActInsurance coverageInsurance coverage gapsMultivariate logistic regressionCoverage gapSocioeconomic disparitiesCare objectivesSociodemographic disparitiesRacial disparitiesLow-incomeNonelderly adultsLogistic regressionMedicaidBlack patientsDisparitiesEarly impactInsurancePotential benefitsPatientsCancerAffordabilityEmergency Department Visits for Opioid Overdoses Among Patients With Cancer
Jairam V, Yang DX, Yu JB, Park HS. Emergency Department Visits for Opioid Overdoses Among Patients With Cancer. Journal Of The National Cancer Institute 2019, 112: 938-943. PMID: 31845985, PMCID: PMC7492769, DOI: 10.1093/jnci/djz233.Peer-Reviewed Original ResearchConceptsOpioid-related ED visitsED visitsEmergency departmentOpioid overdoseComorbid diagnosesUtilization Project Nationwide Emergency Department SampleMultivariable logistic regression analysisNationwide Emergency Department SampleHigh opioid useOpioid-related visitsPrimary disease siteEmergency department visitsEmergency Department SampleLogistic regression analysisSubstance use disordersOpioid useDepartment visitsChronic painMultiple myelomaNeck cancerPrimary diagnosisRisk factorsPatient visitsBaseline differencesOpioid overdosesIncome disparities in needle biopsy patients prior to breast cancer surgery across physician peer groups
Killelea BK, Herrin J, Soulos PR, Pollack CE, Forman HP, Yu J, Xu X, Tannenbaum S, Wang SY, Gross CP. Income disparities in needle biopsy patients prior to breast cancer surgery across physician peer groups. Breast Cancer 2019, 27: 381-388. PMID: 31792804, PMCID: PMC7512133, DOI: 10.1007/s12282-019-01028-4.Peer-Reviewed Original ResearchConceptsPhysician peer groupsLow-income patientsNeedle biopsyOdds ratioHigh-income patientsBreast cancer surgeryMethodsThe SurveillanceCancer surgeryIncome patientsMedicare databaseBiopsy patientsMedicare beneficiariesPatientsBiopsyLow incomeGroupDisparitiesReceiptEnd resultHigher incomeSurgeryPeer groupEpidemiologyFurther workGroup-level effects