2021
Modelling the intervention effect of opioid agonist treatment on multiple mortality outcomes in people who inject drugs: a three-setting analysis
Stone J, Degenhardt L, Grebely J, Larney S, Altice FL, Smyrnov P, Rahimi-Movaghar A, Alavi M, Young AM, Havens JR, Miller WC, Hickman M, Vickerman P. Modelling the intervention effect of opioid agonist treatment on multiple mortality outcomes in people who inject drugs: a three-setting analysis. The Lancet Psychiatry 2021, 8: 301-309. PMID: 33640039, PMCID: PMC8255389, DOI: 10.1016/s2215-0366(20)30538-1.Peer-Reviewed Original ResearchConceptsOpioid agonist treatmentDrug-related deathsOAT coverageDrug-related harmAgonist treatmentHepatitis C virus transmissionC virus transmissionOverall health benefitsUK National InstituteNational InstituteHIV 0OAT retentionHIV mortalityInjury 3Opioid dependenceMortality outcomesUS National InstitutesHCV-2Overdose deathsSignificant additional effectIntervention effectsDrug abuseHealth benefitsMortalityDeath
2019
Effect of expanding opioid agonist therapies on the HIV epidemic and mortality in Ukraine: a modelling study
Tan J, Altice FL, Madden LM, Zelenev A. Effect of expanding opioid agonist therapies on the HIV epidemic and mortality in Ukraine: a modelling study. The Lancet HIV 2019, 7: e121-e128. PMID: 31879250, PMCID: PMC7289179, DOI: 10.1016/s2352-3018(19)30373-x.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidHIV InfectionsHumansIncidenceModels, TheoreticalOpiate Substitution TreatmentPrevalenceRiskSubstance Abuse, IntravenousUkraineConceptsOpioid agonist therapyNew HIV infectionsHigh HIV burdenHIV infectionMinistry of HealthOAT coverageAgonist therapyHIV burdenHIV incidenceBuprenorphine maintenance therapyPublic Health CenterMaintenance therapyHIV outcomesHIV prevalenceHIV transmissionMedication procurementHIV epidemicHealth centersHIV preventionTreatment goalsPWIDOAT expansionDisease controlSexual riskInfectionCost‐effectiveness of expanding the capacity of opioid agonist treatment in Ukraine: dynamic modeling analysis
Morozova O, Crawford FW, Cohen T, Paltiel AD, Altice FL. Cost‐effectiveness of expanding the capacity of opioid agonist treatment in Ukraine: dynamic modeling analysis. Addiction 2019, 115: 437-450. PMID: 31478285, PMCID: PMC7015766, DOI: 10.1111/add.14797.Peer-Reviewed Original ResearchConceptsOpioid agonist treatmentOpioid use disorderOAT coverageAgonist treatmentGross domestic productOpioid use initiationOpioid addiction epidemicOAT accessHIV epidemicUse disordersAddiction epidemicCapita gross domestic productPay thresholdsTreatment demandUse initiationAddiction treatmentIncremental costBaseline capacityTreatmentPotential peer effectsDomestic productTreatment spilloversEpidemicPeer effectsCoverage levels
2016
The complex interplay of social networks, geography and HIV risk among Malaysian Drug Injectors: Results from respondent-driven sampling
Zelenev A, Long E, Bazazi AR, Kamarulzaman A, Altice FL. The complex interplay of social networks, geography and HIV risk among Malaysian Drug Injectors: Results from respondent-driven sampling. International Journal Of Drug Policy 2016, 37: 98-106. PMID: 27639995, PMCID: PMC5102779, DOI: 10.1016/j.drugpo.2016.08.008.Peer-Reviewed Original ResearchConceptsHIV statusHIV transmissionClean needlesRecent injection partnersHigh-risk populationRisk reduction interventionsTargeting of interventionsPublic health surveillanceRespondent-driven samplingInjection partnersHIV preventionHIV riskTreatment coverageDrug injectorsHIVPrevention strategiesPWIDHealth surveillanceGreater Kuala LumpurKuala LumpurInterventionSurveillanceImportant mechanismStatus
2015
Harnessing Case Isolation and Ring Vaccination to Control Ebola
Wells C, Yamin D, Ndeffo-Mbah ML, Wenzel N, Gaffney SG, Townsend JP, Meyers LA, Fallah M, Nyenswah TG, Altice FL, Atkins KE, Galvani AP. Harnessing Case Isolation and Ring Vaccination to Control Ebola. PLOS Neglected Tropical Diseases 2015, 9: e0003794. PMID: 26024528, PMCID: PMC4449200, DOI: 10.1371/journal.pntd.0003794.Peer-Reviewed Original ResearchMeSH KeywordsDisease OutbreaksEbolavirusHemorrhagic Fever, EbolaHumansIncidenceLiberiaModels, TheoreticalPublic HealthSierra LeoneVaccinationConceptsRing vaccinationCase isolationContact tracingLimited initial supplyPost-exposure protectionMass vaccination campaignNon-pharmaceutical control measuresPublic health agenciesCandidate vaccinesVaccination campaignVaccinationCase contactsEbola casesEbola transmissionHealth agenciesIncidence dataLow efficacyVaccineEbola outbreakEffective alternativeMore contactEbolaSierra LeoneBeneficial supplementControl measuresThe Impact of Implementing a Test, Treat and Retain HIV Prevention Strategy in Atlanta among Black Men Who Have Sex with Men with a History of Incarceration: A Mathematical Model
Lima VD, Graf I, Beckwith CG, Springer S, Altice FL, Coombs D, Kim B, Messina L, Montaner JS, Spaulding A. The Impact of Implementing a Test, Treat and Retain HIV Prevention Strategy in Atlanta among Black Men Who Have Sex with Men with a History of Incarceration: A Mathematical Model. PLOS ONE 2015, 10: e0123482. PMID: 25905725, PMCID: PMC4408043, DOI: 10.1371/journal.pone.0123482.Peer-Reviewed Original ResearchMeSH KeywordsAIDS SerodiagnosisBlack or African AmericanGeorgiaHIV InfectionsHomosexuality, MaleHumansMaleModels, TheoreticalConceptsHIV prevalenceNew infectionsCondom useSexual risk behavior changePrevalence of HIVHIV prevention strategiesCumulative numberRisk behavior changeHistory of incarcerationBlack menHIV incidenceHIV transmissionHIV epidemicPrevention strategiesPrevalenceInfectionMortalityMenPrison releaseBehavior changeStatus quo scenarioSexUnited StatesYearsSetting
2014
Dynamics and control of Ebola virus transmission in Montserrado, Liberia: a mathematical modelling analysis
Lewnard JA, Mbah M, Alfaro-Murillo JA, Altice FL, Bawo L, Nyenswah TG, Galvani AP. Dynamics and control of Ebola virus transmission in Montserrado, Liberia: a mathematical modelling analysis. The Lancet Infectious Diseases 2014, 14: 1189-1195. PMID: 25455986, PMCID: PMC4316822, DOI: 10.1016/s1473-3099(14)70995-8.Peer-Reviewed Original ResearchMeSH KeywordsBasic Reproduction NumberDisease Transmission, InfectiousHemorrhagic Fever, EbolaHumansInfection ControlLiberiaModels, TheoreticalConceptsEVD casesCase ascertainmentTreatment centersCases of EVDEbola virus disease epidemicPrimary outcome measureEbola virus transmissionPublic health responseIntervention initiationUS National InstitutesOutcome measuresHealth responseNumber of bedsContact tracingMontserrado CountyEbola virusAdditional bedsBasic reproductive numberVirus transmissionAscertainmentNational InstituteInterventionEVDDeathMathematical modelling analysis