2024
A qualitative dyad analysis of barriers and facilitators of antiretroviral therapy (ART) adherence among people who inject drugs (PWID) with HIV in Kazakhstan
Neuenschwander P, Altice F, Remien R, Mergenova G, Sarsembayeva L, Rozental E, Gulyayev V, Davis A. A qualitative dyad analysis of barriers and facilitators of antiretroviral therapy (ART) adherence among people who inject drugs (PWID) with HIV in Kazakhstan. AIDS Care 2024, ahead-of-print: 1-10. PMID: 39404196, DOI: 10.1080/09540121.2024.2414078.Peer-Reviewed Original ResearchAntiretroviral therapy adherenceSocial supportART adherenceFacilitators of ART adherenceBarriers to ART adherenceAntiretroviral therapyART adherence interventionsInjection drug useDyad analysisAdherence interventionsAdherence barriersLack of awarenessHIV epidemicAdherencePWIDDrug useHIVInterpersonal levelRelationship contextDyad membersFacilitationIndividual levelPWHDyadsIntimate partners
2022
Implementation of a Dyad-Based Intervention to Improve Antiretroviral Therapy Adherence Among HIV-Positive People Who Inject Drugs in Kazakhstan: A Randomized Trial
Davis A, Mergenova G, Landers S, Sun Y, Rozental E, Gulyaev V, Gulyaev P, Nurkatova M, Terlikbayeva A, Primbetova S, Altice F, Remien R. Implementation of a Dyad-Based Intervention to Improve Antiretroviral Therapy Adherence Among HIV-Positive People Who Inject Drugs in Kazakhstan: A Randomized Trial. Research On Social Work Practice 2022, 33: 313-324. PMID: 37576461, PMCID: PMC10421639, DOI: 10.1177/10497315221117543.Peer-Reviewed Original ResearchHIV-positive PWIDAntiretroviral therapy adherenceHIV-positive peopleTherapy adherenceART adherence interventionsStandard of careSupport partnersART adherenceAdherence interventionsIntervention deliveryPWIDTraining of staffInterventionTrialsAdherenceCouple interventionsSocial supportFamily membersDrugsIntimate partnersRemote deliveryCollection of assessmentsImplementation strategiesDeliveryAdapted version
2021
Assessing mobile technology use and mHealth acceptance among HIV-positive men who have sex with men and transgender women in Malaysia
Krishnan A, Weikum D, Cravero C, Kamarulzaman A, Altice FL. Assessing mobile technology use and mHealth acceptance among HIV-positive men who have sex with men and transgender women in Malaysia. PLOS ONE 2021, 16: e0248705. PMID: 33755693, PMCID: PMC7987189, DOI: 10.1371/journal.pone.0248705.Peer-Reviewed Original ResearchConceptsSuboptimal ART adherenceTransgender womenAntiretroviral therapyART adherenceHIV-positive MSMHIV-positive populationInjection drug useHIV-positive menAcceptability of mHealthRisky sexual behaviorHIV preventionTreatment strategiesUnsafe sexDrug useMHealth acceptanceExcellent accessMHealth platformSexual behaviorMenMobile healthSocietal stigmaSexMSMMHealth researchWomen
2019
Self-reported antiretroviral therapy adherence and viral load in criminal justice-involved populations
Cunningham WE, Nance RM, Golin CE, Flynn P, Knight K, Beckwith CG, Kuo I, Spaulding A, Taxman FS, Altice F, Delaney JA, Crane HM, Springer SA. Self-reported antiretroviral therapy adherence and viral load in criminal justice-involved populations. BMC Infectious Diseases 2019, 19: 913. PMID: 31664910, PMCID: PMC6819597, DOI: 10.1186/s12879-019-4443-z.Peer-Reviewed Original ResearchConceptsViral loadART adherenceAdherence measuresSelf-reported antiretroviral therapy (ART) adherenceCriminal justice-involved populationsSelf-reported ART adherenceLogistic regressionSelf-reported health statusContinuum of HIVDetectable viral loadPlasma viral loadAIDS Research NetworkAntiretroviral therapy adherenceAssociation of adherenceHealth status levelsVisual analog scaleViral load dataMixed-effects logistic regressionMixed effects linear regressionEffects linear regressionJustice-involved populationsEffects logistic regressionVL outcomesCD4 countART dosesAdherence to HIV treatment regimens: systematic literature review and meta-analysis
Altice F, Evuarherhe O, Shina S, Carter G, Beaubrun AC. Adherence to HIV treatment regimens: systematic literature review and meta-analysis. Patient Preference And Adherence 2019, 13: 475-490. PMID: 31040651, PMCID: PMC6452814, DOI: 10.2147/ppa.s192735.Peer-Reviewed Original ResearchViral suppressionTreatment adherenceAntiretroviral therapySystematic reviewART adherence levelsComplete treatment regimenHigher adherence ratesHuman immunodeficiency virusSuboptimal treatment adherenceHigh treatment adherenceLevel of adherenceObservational settingTablet regimensPill burdenART adherenceRegimen complexityTablet burdenTreatment regimenImmunodeficiency virusAdherence ratesHIV treatmentObservational studyAdherence levelsMeta-AnalysisViral transmissionHIV-Related Stigma, Motivation to Adhere to Antiretroviral Therapy, and Medication Adherence Among HIV-Positive Methadone-Maintained Patients
Shrestha R, Altice FL, Copenhaver MM. HIV-Related Stigma, Motivation to Adhere to Antiretroviral Therapy, and Medication Adherence Among HIV-Positive Methadone-Maintained Patients. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 80: 166-173. PMID: 30383588, PMCID: PMC6331231, DOI: 10.1097/qai.0000000000001891.Peer-Reviewed Original ResearchConceptsOptimal ART adherenceAntiretroviral therapyMethadone-maintained patientsMethadone maintenance treatmentART adherenceMaintenance treatmentHIV treatment outcomesHIV-positive patientsOpioid agonist therapyMultivariable logistic regressionHIV risk behaviorsExplanatory pathwaysAgonist therapySuboptimal adherenceMedication adherenceHIV treatmentTreatment outcomesHIV stigmaPatientsLogistic regressionHIVPrevention initiativesTherapyAdherenceSignificant correlates
2018
Adherence to Antiretroviral Therapy Among Incarcerated Persons with HIV: Associations with Methadone and Perceived Safety
Culbert GJ, Waluyo A, Wang M, Putri TA, Bazazi AR, Altice FL. Adherence to Antiretroviral Therapy Among Incarcerated Persons with HIV: Associations with Methadone and Perceived Safety. AIDS And Behavior 2018, 23: 2048-2058. PMID: 30465106, PMCID: PMC6698149, DOI: 10.1007/s10461-018-2344-6.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyART adherenceART utilizationMethadone utilizationHIV status disclosureHealth service satisfactionStatus disclosureMedical treatmentDrug dependencyPWHAdherenceMost participantsHIVMethadoneTherapyChance locusSafetyAdequate supportHigh levelsPerceived SafetyPersonal safety
2017
An explanatory factor analysis of a brief self-report scale to detect neurocognitive impairment among HIV-positive men who have sex with men and transgender women in Peru
Weikum D, Shrestha R, Ferro EG, Vagenas P, Copenhaver M, Spudich S, Alpert MD, Cabello R, Lama JR, Sanchez J, Altice FL. An explanatory factor analysis of a brief self-report scale to detect neurocognitive impairment among HIV-positive men who have sex with men and transgender women in Peru. AIDS Care 2017, 29: 1297-1301. PMID: 28449599, PMCID: PMC6337065, DOI: 10.1080/09540121.2017.1322681.Peer-Reviewed Original ResearchConceptsHIV-positive menNeuropsychological Impairment ScaleNeurocognitive impairmentTransgender womenAntiretroviral therapyHIV-positive MSMPoor clinical outcomeHIV risk behaviorsClinical care settingsHealth-related outcomesExploratory factor analysisART adherenceClinical outcomesPatient populationCare settingsImpairment ScaleRisk behaviorsImpairmentMenPrincipal axis factoringSelf-report scalesOrthogonal varimax rotationWomenBrief self-report scaleOutcomes
2016
Community-Based Interventions to Improve and Sustain Antiretroviral Therapy Adherence, Retention in HIV Care and Clinical Outcomes in Low- and Middle-Income Countries for Achieving the UNAIDS 90-90-90 Targets
Nachega JB, Adetokunboh O, Uthman OA, Knowlton AW, Altice FL, Schechter M, Galárraga O, Geng E, Peltzer K, Chang LW, Van Cutsem G, Jaffar SS, Ford N, Mellins CA, Remien RH, Mills EJ. Community-Based Interventions to Improve and Sustain Antiretroviral Therapy Adherence, Retention in HIV Care and Clinical Outcomes in Low- and Middle-Income Countries for Achieving the UNAIDS 90-90-90 Targets. Current HIV/AIDS Reports 2016, 13: 241-255. PMID: 27475643, PMCID: PMC5357578, DOI: 10.1007/s11904-016-0325-9.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsCommunity Health CentersCross-Sectional StudiesDeveloping CountriesHealth EducationHealth Services AccessibilityHIV InfectionsHumansMedication AdherenceObservational Studies as TopicPatient DropoutsRandomized Controlled Trials as TopicSustained Virologic ResponseUnited NationsConceptsHealth facility-based interventionsFacility-based interventionsAntiretroviral therapy adherenceCommunity-based interventionsVirologic suppressionCohort studyMiddle-income countriesClinical outcomesTherapy adherenceRelative riskComparable outcomesCommunity-based ART delivery modelTreatment engagementART delivery modelsFacility-based modelsComparative cohort studyRelevant clinical outcomesRandom-effects modelLeast comparable outcomesStable HIVCause mortalityHIV careART adherenceUNAIDS 90ART deliverySocial Network Strategies to Address HIV Prevention and Treatment Continuum of Care Among At-risk and HIV-infected Substance Users: A Systematic Scoping Review
Ghosh D, Krishnan A, Gibson B, Brown SE, Latkin CA, Altice FL. Social Network Strategies to Address HIV Prevention and Treatment Continuum of Care Among At-risk and HIV-infected Substance Users: A Systematic Scoping Review. AIDS And Behavior 2016, 21: 1183-1207. PMID: 27125244, PMCID: PMC5085887, DOI: 10.1007/s10461-016-1413-y.Peer-Reviewed Original ResearchConceptsSocial network-based interventionHIV preventionSubstance usersHIV care continuumSystematic review highlightsCare linkageViral suppressionART adherenceSystematic scoping reviewEvidence-based practiceCare continuumTreatment continuumSystematic reviewNetwork-based interventionsPreventionHIVScoping ReviewReview highlightsSocial network strategyBibliographic databasesInterventionTreatmentMost studiesReviewStudyAcceptability and feasibility of mHealth and community-based directly observed antiretroviral therapy to prevent mother-to-child HIV transmission in South African pregnant women under Option B+: an exploratory study
Nachega JB, Skinner D, Jennings L, Magidson JF, Altice FL, Burke JG, Lester RT, Uthman OA, Knowlton AR, Cotton MF, Anderson JR, Theron GB. Acceptability and feasibility of mHealth and community-based directly observed antiretroviral therapy to prevent mother-to-child HIV transmission in South African pregnant women under Option B+: an exploratory study. Patient Preference And Adherence 2016, Volume 10: 683-690. PMID: 27175068, PMCID: PMC4854240, DOI: 10.2147/ppa.s100002.Peer-Reviewed Original ResearchFeasibility of mHealthHIV status disclosurePregnant womenAntiretroviral therapyTreatment supportersStatus disclosureChild human immunodeficiency virus (HIV) transmissionCommunity primary care clinicsHuman immunodeficiency virus (HIV) transmissionPregnant South African womenART adherence interventionsAntiretroviral therapy regimenChild HIV transmissionAntiretroviral therapy adherencePrimary care clinicsSouth African pregnant womenMobile phone accessAfrican pregnant womenFocus group discussionsSMS text messagingPMTCT servicesSouth African womenART adherencePhone accessTherapy regimen
2015
Challenges in managing HIV in people who use drugs
Kamarulzaman A, Altice FL. Challenges in managing HIV in people who use drugs. Current Opinion In Infectious Diseases 2015, 28: 10-16. PMID: 25490106, PMCID: PMC4409950, DOI: 10.1097/qco.0000000000000125.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsCoinfectionComorbidityContinuity of Patient CareHealth Services AccessibilityHepatitis CHIV InfectionsHumansMedication AdherenceMental DisordersNeedle-Exchange ProgramsOpiate Substitution TreatmentSocial ClassSubstance Abuse, IntravenousSubstance-Related DisordersTuberculosisConceptsOpioid substitution therapyHepatitis C virusHIV continuumTreatment outcomesImproved ART adherenceInterferon-based regimesTB treatment outcomesHIV treatment outcomesBetter treatment retentionEvidence-based preventionHIV treatment accessHIV-HCVNoninfectious comorbiditiesOST servicesCare retentionART adherenceHIV managementAntiretroviral adherencePsychiatric comorbiditySubstitution therapyHIV treatmentNew diagnostic technologiesC virusClinical managementEarly diagnosis
2014
Communication technology use and mHealth acceptance among HIV-infected men who have sex with men in Peru: implications for HIV prevention and treatment
Krishnan A, Ferro EG, Weikum D, Vagenas P, Lama JR, Sanchez J, Altice FL. Communication technology use and mHealth acceptance among HIV-infected men who have sex with men in Peru: implications for HIV prevention and treatment. AIDS Care 2014, 27: 273-282. PMID: 25285464, PMCID: PMC4305474, DOI: 10.1080/09540121.2014.963014.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlcohol DrinkingAnti-Retroviral AgentsCell PhoneEducationFemaleHealth SurveysHIV InfectionsHomosexuality, MaleHumansMaleMedication AdherenceMiddle AgedPeruPovertyPrevalenceRisk FactorsSexual BehaviorSurveys and QuestionnairesTelemedicineText MessagingTransgender PersonsConceptsAlcohol use disorderTransgender womenMHealth acceptancePoor HIV treatment outcomesHIV treatment outcomesAntiretroviral therapy adherenceSuboptimal ART adherenceHIV risk behaviorsART adherenceRisky sexual behaviorPeruvian MSMTherapy adherenceHIV epidemicHIV preventionTreatment outcomesHIV interventionsUse disordersMedication remindersHealth professionalsHIVMSMConvenience sampleMost participantsIntervention strategiesStandardized assessmentAlcohol use disorders negatively influence antiretroviral medication adherence among men who have sex with men in Peru
Ferro EG, Weikum D, Vagenas P, Copenhaver MM, Gonzales P, Peinado J, Cabello R, Lama JR, Sanchez J, Altice FL. Alcohol use disorders negatively influence antiretroviral medication adherence among men who have sex with men in Peru. AIDS Care 2014, 27: 93-104. PMID: 25277252, PMCID: PMC4221495, DOI: 10.1080/09540121.2014.963013.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyART adherenceAlcohol use disorderART nonadherenceIndependent correlatesUse disordersHIV treatment engagementOnly independent correlateClinical care sitesConcentrated HIV epidemicAntiretroviral medication adherenceRecent drug useEvidence-based strategiesStandardized screening measuresAdherence surveyMedication adherenceHIV treatmentHIV epidemicCare sitesClinical careNeurocognitive impairmentMeeting criteriaSectional surveyTreatment engagementDrug use
2012
Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International Association of Physicians in AIDS Care panel.
Thompson MA, Mugavero MJ, Amico KR, Cargill VA, Chang LW, Gross R, Orrell C, Altice FL, Bangsberg DR, Bartlett JG, Beckwith CG, Dowshen N, Gordon CM, Horn T, Kumar P, Scott JD, Stirratt MJ, Remien RH, Simoni JM, Nachega JB. Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International Association of Physicians in AIDS Care panel. Annals Of Internal Medicine 2012, 156: 817-33, w-284, w-285, w-286, w-287, w-288, w-289, w-290, w-291, w-292, w-293, w-294. PMID: 22393036, PMCID: PMC4044043, DOI: 10.7326/0003-4819-156-11-201206050-00419.Peer-Reviewed Original ResearchConceptsEvidence-based recommendationsAntiretroviral therapyART adherenceBody of evidenceHIV medical careStandardized data extraction formEffective antiretroviral therapyHIV treatment outcomesService delivery interventionsMental health disordersData extraction formSystematic literature searchHIV diagnosisBehavioral end pointsAdherence toolsAntiretroviral adherencePregnant womenDelivery interventionsAIDS careTreatment outcomesObservational studyCare panelHealth disordersExtraction formMedical care