Setting ambitious targets for surveillance and treatment rates among patients with hepatitis C related cirrhosis impacts the cost-effectiveness of hepatocellular cancer surveillance and substantially increases life expectancy: A modeling study
Uyei J, Taddei TH, Kaplan DE, Chapko M, Stevens ER, Braithwaite RS. Setting ambitious targets for surveillance and treatment rates among patients with hepatitis C related cirrhosis impacts the cost-effectiveness of hepatocellular cancer surveillance and substantially increases life expectancy: A modeling study. PLOS ONE 2019, 14: e0221614. PMID: 31449554, PMCID: PMC6709904, DOI: 10.1371/journal.pone.0221614.Peer-Reviewed Original ResearchMeSH KeywordsAgedCost-Benefit AnalysisDisease ProgressionHepatitis CHumansLife ExpectancyLiver CirrhosisLiver NeoplasmsMiddle AgedModels, BiologicalReproducibility of ResultsConceptsIncremental cost-effectiveness ratioCost-effectiveness ratioHCC treatmentLife expectancyDifferent surveillance intervalsDecision-analytic Markov modelHepatitis C virusCause of deathAspirational scenarioCurrent HCVHCC surveillanceHCC incidenceHepatitis CSurveillance intervalsC virusCancer surveillanceVeteran outcomesLower incidenceStudy groupHCVTreatment useCirrhosisEpidemiologic studiesPatientsCompliance rate