John Lee Soto-Vargas
Research
Publications
2025
A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder
Wang J, Liu Y, Li H, Nguyen T, Soto-Vargas J, Wilson R, Wang W, Lam T, Zhang C, Lin C, Lewis D, Glausier J, Holtzheimer P, Friedman M, Williams K, Picciotto M, Nairn A, Krystal J, Duman R, Young K, Zhao H, Girgenti M. A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder. Genome Medicine 2025, 17: 43. PMID: 40301990, PMCID: PMC12042318, DOI: 10.1186/s13073-025-01473-1.Peer-Reviewed Original ResearchTranslaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex
Vargas-Ortiz J, Lin L, Martinez V, Liu R, Babij R, Duan Z, Wacks S, Sun L, Wang A, Khan S, Soto-Vargas J, De Marco García N, Che A. Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex. Nature Communications 2025, 16: 1296. PMID: 39900899, PMCID: PMC11791040, DOI: 10.1038/s41467-024-55783-w.Peer-Reviewed Original ResearchThis study shows how connections across layers in the cortex synchronize early brain activity, guiding sensory development and informing strategies to address neurodevelopmental disorders.
2023
Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons
Dorskind J, Sudarsanam S, Hand R, Ziak J, Amoah-Dankwah M, Guzman-Clavel L, Soto-Vargas J, Kolodkin A. Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons. Journal Of Neuroscience 2023, 43: 7745-7765. PMID: 37798130, PMCID: PMC10648559, DOI: 10.1523/jneurosci.0553-23.2023.Peer-Reviewed Original Research
2018
Effects of histone methyltransferase inhibition in endometriosis†
Colón-Caraballo M, Torres-Reverón A, Soto-Vargas J, Young S, Lessey B, Mendoza A, Urrutia R, Flores I. Effects of histone methyltransferase inhibition in endometriosis†. Biology Of Reproduction 2018, 99: 293-307. PMID: 29408993, PMCID: PMC6373837, DOI: 10.1093/biolre/ioy030.Peer-Reviewed Original Research