Isabella J. Perone
About
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Biography
Isabella received her B.S. in neuroscience from the Johns Hopkins University, where she studied working memory in the Visual Learning Laboratory, as well as age-related cognitive decline in the Laboratory of Neurosciences at the National Institute on Aging at the NIH. Following her graduation, Isabella studied the age-related changes in mitochondrial metabolism associated with Alzheimer's disease at the Laboratory of Genetics and Genomics, at the National Institute on Aging, NIH. At Yale, she is a Gruber Science Fellow and she is a member of the Arnsten lab where she studies the effects of calcium dysregulation on age-related cognitive decline and Alzheimer's pathology in rhesus macaques.
Last Updated on June 12, 2024.
Education & Training
- MPhil
- Yale University, Interdepartmental Neuroscience Program
- Post-Baccalaureate IRTA
- National Institutes of Health
- BS
- The Johns Hopkins University, Neuroscience
Research
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Publications
Featured Publications
Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration.
Datta D, Perone I, Wijegunawardana D, Liang F, Morozov YM, Arellano J, Duque A, Xie Z, van Dyck CH, Arnsten AFT. Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration. BioRxiv 2023 PMID: 37986900, DOI: 10.1101/2023.11.07.566046.Peer-Reviewed Original ResearchMitochondrial SIRT3 Deficiency Results in Neuronal Network Hyperexcitability, Accelerates Age-Related Aβ Pathology, and Renders Neurons Vulnerable to Aβ Toxicity.
Perone I, Ghena N, Wang J, Mackey C, Wan R, Malla S, Gorospe M, Cheng A, Mattson MP. Mitochondrial SIRT3 Deficiency Results in Neuronal Network Hyperexcitability, Accelerates Age-Related Aβ Pathology, and Renders Neurons Vulnerable to Aβ Toxicity. Neuromolecular Medicine 2022 PMID: 35749057, DOI: 10.1007/s12017-022-08713-2.Peer-Reviewed Original ResearchSIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model.
Cheng A, Wang J, Ghena N, Zhao Q, Perone I, King TM, Veech RL, Gorospe M, Wan R, Mattson MP. SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2020, 40: 694-709. PMID: 31818974, PMCID: PMC6961992, DOI: 10.1523/JNEUROSCI.1446-19.2019.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Honors
honor Gruber Science Fellowship
03/10/2020Yale University AwardThe Gruber FoundationDetailsUnited States
Get In Touch
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